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Dr Claire H. Michel

Dr Claire H. Michel

Live cell and organism imaging of amyloid species and their interactions

Research Interests

Alzheimer's and Parkinson's diseases
Trafficking of amyloid proteins in and out of cells
Cell cultures and C. elegans model systems

Other Professional Activities

Molecular Neuroscience Group and Laser Analytics Group

Past member (and chair) of the CEB Postdoc Committee

Member of the Athena SWAN Committee

Member of Robinson College

Key Publications

Pinotsi D*, Michel CH*, Buell AK, Laine RF, Mahou P, Dobson CM, Kaminski CF, Kaminski Schierle GS, "Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons" PNAS (2016). * Joint first authors

Murakami T, Qamar S, Lin JQ, Kaminski Schierle GS, Rees E, Miyashita A,  Costa AR, Dodd RB, Chan FTS, Michel CH,  Kronenberg-Versteeg D, Li Y, Yang S-P,  Wakutani Y, Meadows W, Ferry RR, Dong L,  Tartaglia GG, Favrin G,  Lin W-L,  Dickson DW,  Zhen M,  Ron D,  Schmitt-Ulms G,  Fraser PE,  Shneider NA,  Holt C,  Vendruscolo M, Kaminski CF,  George-Hyslop P.St., "ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function", Neuron (2015).

Kaminski CF, Pinotsi D, Michel CH, Kaminski Schierle GS, "Nanoscale imaging of neurotoxic proteins", SPIE NanoScience+ Engineering (2013).

Michel CH, Kumar S, Pinotsi D, Tunnacliffe A, St George-Hyslop P, Mandelkow E, Mandelkow E-M, Kaminski CF, Kaminski Schierle GS, "Extracellular Monomeric Tau Protein is Sufficient to Initiate the Spread of Tau Protein Pathology",  Journal of Biological Chemistry (2014).

Belorgey D, Irving JA, Ekeowa UI, Freeke J, Roussel BD, Miranda E, Perez J, Robinson CV, Marciniak SJ, Crowther DC, Michel CH, Lomas DA, "Characterisation of serpin polymers in vitro and in vivo", Methods (2011).

 Berger Z, Ttofi EK, Michel CH, Pasco M, Tenant S, Rubinsztein DC, O'Kane CJ, "Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway" Hum. Mol. Genet. (2005).

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