| Drying Technologies |
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There are lots of different ways of removing water...
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The process chosen to formulate a particular drug depends on the intended delivery method as well as the stability of the substance.
Classical Freeze Drying
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Classical freeze drying refers to freeze drying under vacuum, which is used to
produce the majority of today's dried pharmaceuticals. By removing
water from the frozen rather than the liquid state, morphology, solubility
and chemical integrity of the product are for the most part maintained
after freeze drying. Meanwhile, in the presence of vacuum, the drying
rate is accelerated and the drying temperature can be set at a lower
value compared with other drying methods, more...
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Solution Enhanced Dispersion with Supercritical Fluid (SEDS)
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Solution enhanced dispersion with supercritical fluid (SEDS) is a novel technique which enables the production of highly characterised small particles which can be used for inhalable and transdermal delivery,
more...
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Atmospheric Freeze Drying
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Classical freeze drying is carried out under vacuum and SEDS is conducted at high pressures. Both of these options require expensive equipment. However, atmospheric pressure freeze drying does provide another option,
more...
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The montage on the top left of this page shows a number of images related to "Drying Technologies". The Andes mountains are depicted, where freeze drying at atmospheric pressure is possible on the mountainside, as described on the history page. On the right of the image is a lab scale classical freeze dryer, below which is an electron micrograph of a particle produced using SEDS technology. Finally there is also an image of someone using the needle-free powderject drug delivery device. |
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