A new technology under development in this department protects bacteria-based oral vaccines from destruction by the digestive system, to enable their safe delivery to the body's immune system.
Developed by Alexander Edwards, Krishnaa Mahbubani and Professor Nigel Slater in the University of Cambridge Department of Chemical Engineering and Biotechnology, the technology uses a material called bile-acid adsorbing resins (BARs) to protect bacteria from the destructive effects of bile in the small intestine. BAR is mixed with dried bacteria in a capsule that can be swallowed. The movement of bile into the capsule is held back by the resin long enough for water to rehydrate the bacteria, before the capsule finally breaks open, enabling the bacteria to survive.
Vaccine to end curse of Delhi belly - The Telegraph
Clearing the BAR to oral vaccines - University web site
Clearing the BAR to oral vaccines - Medical Xpress