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OPR&D highlights

last modified Mar 03, 2017 02:29 PM
Featured paper from Sustainable Reaction Engineering group
OPR&D highlights

Lead author Dr Polina Yaseneva

Conventional methods of synthesis used in pharmaceutical and speciality chemicals industries often result in significant amounts of waste per unit mass of a product. This is not good for the environment, leads to a poor image of the chemical industry in society, and loss of competitiveness of the industry. Rapid development of green chemistry and green engineering over the past two decades has clearly demonstrated the benefits of cleaner catalytic chemistry and of the more advanced continuous flow processes for pharmaceutical and fine chemistry industries.

A recent paper by members of the Sustainable Reaction Engineering group shows how they developed a flow mini-plant to validate the catalyst recycling strategy for such a process and this paper has been selected by Organic Process Research & Development (OPR&D) as one of the Highlights from the Literature.

Continuous flow Buchwald–Hartwig amination of a pharmaceutical intermediate
Polina Yaseneva, Paul Hodgson, Jacek Zakrzewski, Sebastian Falß, Rebecca E. Meadows and Alexei A. Lapkin  React. Chem. Eng., 2016, 1, 229  DOI: 10.1039/c5re00048c

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