People

Mr. Ali Yetisen

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Position PhD student
College Darwin
Qualifications/honours B.S. in Mechanical Engineering
Address
Department of Chemical Engineering and Biotechnology
(previously Institute of Biotechnology)
University of Cambridge
Tennis Court Road
Cambridge
CB2 1QT
Email ay283@cam.ac.uk
Telephone +44 (0)1223 (7)67782
Research group Healthcare Biotechnology
Research project title Microfluidic point-of-care diagnostic devices
Supervisor Prof. Christopher R. Lowe
Advisor Dr. Geoff Moggridge

Research description

Dipstick and lateral-flow formats have dominated rapid diagnostics over the last three decades. These formats gained popularity in the consumer markets due to their compactness, portability and facile interpretation without external instrumentation. However, lack of quantitation in measurements has challenged the demand of existing assay formats in consumer markets. Recently, paper-based microfluidics as emerged as a multiplexable point-of-care platform which might transcend the capabilities of existing assays in resource-limited settings. However, paper-based microfluidics can enable fluid handling and quantitative analysis for potential applications in healthcare, veterinary medicine, environmental monitoring and food safety. Currently, in its early development stages, paper-based microfluidics is considered a low-cost, lightweight, and disposable technology.

The purpose of my project is to characterise and optimise photonic crystal-based sensing mechanims for applications in paper-based microfluidics.

Research keywords

diagnostics, global health, microfluidics, biosensor, water-electrolyte imbalance, rapid test, lateral flow, dipstick, telemedicine, mobile health, resource-limited, resource-poor, point-of-care, photonic crystal, bragg reflector, bragg mirror, structual

Main collaborators

Fernando Vasconcellos, Department of Chemical Engineering and Biotechnology, University of Cambridge
Anna Andreou, Department of Chemistry, University of Cambridge
Haider Butt, Department of Engineering, University of Cambridge
Yunuen Montelongo, Department of Engineering, University of Cambridge
Malik Qasim, Department of Engineering, University of Cambridge
Caterina Ducati, Department of Materials Science and Metallurgy, University of Cambridge
J. Bryan Carmody, Division of Pediatric Nephrology, University of Virginia Children's Hospital

Key publications

Yetisen, A.K., Akram, M.S., Lowe, C.R. Paper-based microfluidic point-of-care diagnostic devices. Lab Chip, 2013, 13 (12), 2210 - 2251

Yetisen, A.K., Jiang, L., Cooper, J.R., Qin, Y., Palanivelu, R., and Zohar, Y. A microsystem-based assay for studying pollen tube guidance in plant reproduction. J. Micromech. Microeng. 21 (2011) 054018

Cell Staining with Air Quenched Steam Heating, WO2011139976, 2011.

Other information

Cambridge Infectious Diseases

http://www.infectiousdisease.cam.ac.uk