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High resolution structural tools

Summary

In the growing field of therapeutic proteins, the potency and stability of these large drug molecules depend critically on optimising their conformational and colloidal dynamics. Additionally, there are opportunities for new classes of medicine which harness triggered changes in the structure of the molecule to alter intrinsic function. Central to exploiting these possibilities is the need to first understand how the structure and dynamics of these large and complex molecules relate to key physicochemical properties. There is immediate potential to gain insight which may have significant impact on cutting-edge biopharmaceutical engineering and development strategies.

University Key Personnel: Prof. Nigel Slater

Post-doctoral Research Associate: Jonathan Phillips

MedImmune Key Personnel: Daniel Higazi