Dr. Gabriele Kaminski Schierle is a trained biologist and has a PhD in Medicine from Lund University, Sweden. Her interest is in understanding protein misfolding associated with neurodegenerative diseases at a molecular level within a cellular environment. In order to achieve the molecular level understanding of protein misfolding in cells she applies superresolution imaging methods as developed in the Laser Analytics Group.
Dr. Claire Michel has been in the group for 5 years, has a background in Neurosciences, expertise in neuronal, C. elegans, and Drosophila cultures, and applies several of the group's advanced microscopes for her research. She leads the study of the propagation of Tau from cell to cell and regularly participates in other research projects carried out with collaborators.
Dr. Janin Lautenschläger joined the group 2015 after finishing her PhD in Neuroscience at Jena University Hospital (Germany). She looks at the aggregation of α-synuclein and underlying mechanisms. The main focus of her work is to elucidate in primary dopaminergic neurons how mitochondrial dysfunction and α-synuclein aggregation are cross-linked.
Dr Colin Hockings received his PhD at the Walter & Eliza Hall Institute in Melbourne, Australia, studying how the Bcl-2 family of proteins regulate cell death. In the molecular neuroscience group, he examines the propagation of tau, with special attention to how glial cells are involved.
Dr Ya Zhou started in the group in December 2015 as a joint Postdoc with Prof. Gillian Bates from UCL Huntington's Disease Centre. She has a PhD in Neuroscience from King's College London. She is working on the underlying mechanism of seeding and polymerization of Huntingtin.
Dr. Amberley Stephens is a Research Assistant in the group, having completed a PhD in molecular biology. Her role includes cloning and modification of genes, construction of plasmids and purification of the recombinant proteins, amyloid-β, tau and α-synuclein. She works closely with other members of the group on various biology experiments.
Na Yu joined the group at 2013 funded by EPSRC. Na’s PhD research is focused on developing microfluidic devices to investigate protein aggregation in Alzheimer’s disease using super-resolution. Na is currently working with Claire on the propagation of Tau.
Suil Collins is a PhD student funded by the BBSRC doctorate training partnership program. She is working on the identification and development of small molecules capable of inhibiting the aggregation of amyloidogenic proteins, in collaboration with the groups of Prof David Spring and Dr Florian Hollfelder.
Jhalique Jane Fojas is a PhD student working on developing an integrated microfluidic-nanosensor system for neuro-functional imaging and neurotransmission detection. This novel platform will be used to understand the pathological mechanism of common neurological diseases through protein misfolding and molecular transport studies.
Philippa Hooper is a PhD student working in collaboration with the Cambridge Graphene Centre. She develops devices with transparent graphene electrodes to combine electrophysiological measurements of neuronal activity with fluorescence imaging.
Miranda Robbins is a first year Sensor CDT PhD student with a background in Molecular Biology and Neuroscience. With MedImmune she is investigating whether tau trafficking can be inhibited, with a particular focus on synaptic mechanisms.
Genevieve Simpson started in the group in Oct 2015 as a Master's student. She has a BSc in Neuroscience and is working with fluorescent proteins to monitor the movement of tau within primary hippocampal neurons, subsequently aiming to visualise its movement across the synapse.
Maria Zacharopoulou started in the group in Oct 2016 as a joint Master’s student with Dr. J.J. Phillips. She has a Diploma in Chemical Engineering from NTUA (Athens). In the group, she is working with Hydrogen/Deuterium-exchange Mass Spectrometry to determine the sub-molecular structure and dynamics of alpha-synuclein.
Sina Schack is a Sensor CDT student from the 2016/17 cohort. She received her Bachelor’s degree in Chemistry from Lindenwood University near St. Louis. Following, she graduated with an MSc in Systems and Synthetic Biology from the University of Edinburgh. She joined the group to do her mini-project on amyloid protein strains.
Dr. Dorothea Pinotsi joined the group in 2012, she is a trained physicist and works at the interface between biology and physics. She pioneered the intrinsic fluorescence on amyloid proteins and on α-synuclein strain formation.
Kevin Batenburg joined the group as an MRes student from the University of Amsterdam. He further established a novel methodology to sense and sort single α-synuclein fibrils by nanopores and microfluidic techniques.
Samantha Beck joined the group as a research assistant after passing her Masters degree. She was in charge of cell cultures and interacted closely with team members to conduct biological experiments.