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Dr Alessio Zaccone


2018 -        : Professor of Theoretical Condensed Matter Physics, University of Milan

2018 -        : Visiting faculty, University of Cambridge

2015 - 2018: University Lecturer, and Head of the Statistical Physics Group, University of Cambridge

2014 - 2015: W2 Professor of Theoretical Physics, Physik-Department,
Technical University Munich

2011 - 2014: Oppenheimer Research Fellow, Cavendish Laboratory,
University of Cambridge

2010 - 2011: Swiss National Science Foundation Fellow, Cavendish Laboratory, University of Cambridge

2006 - 2010: PhD in Chemical Physics, ETH Zurich

2000 - 2005: Laurea (MSc),  Politecnico di Torino

Termination details:

Dr Zaccone has returned to Italy to take up the post of Associate Professor at the University of Milan.

Research Interests

Alessio Zaccone and his group are interested in obtaining a deeper understanding of the atomic and molecular-level many-body dynamics in a variety of condensed matter systems and materials, from liquids to glasses, crystals and granulars. He and his group aim to combine two fundamental schools of thought in condensed matter physics: one known as atomistic theory of real solids, the historical continuation of the works of Enrico Fermi, Edward Teller, Max Born, John Slater, Walter Kohn among others, and the other known as the nonequilibrium statistical mechanics approach to condensed matter, going back to Hendrik A. Kramers, Léon van Hove, Robert Zwanzig, and Wolfgang Goetze among others.

One of his main interests at the moment is the development of nonaffine lattice dynamics, which is a general theory framework for disordered condensed matter systems (e.g. defective crystals, liquids and glasses) with many applications ranging from the molecular spectroscopy (Brillouin and Raman) of liquids and solids, to the mechanical, electronic and thermal properties of metallic glasses, polymer glasses, molecular glasses, colloids and suspensions, nuclear materials, and granular systems. He is also very much interested in biomolecular systems and their self-assemby into aggregates and large-scale structures, with applications in biotechnology and medical science.

Alessio Zaccone, who has been awarded the title of Professor of Physics in Germany and in Switzerland, has published 85 articles in peer-reviewed journals (since 2007) on several problems of physics (incl. condensed matter, statistical physics, soft and biological matter, astrophysics and plasma physics, nuclear physics), physical chemistry, metallurgy, and on engineering-motivated problems.

In 2017, he has been listed by the American Chemical Society journal Industrial & Engineering Chemistry Research as one of the 37 most influential scientists of his generation worldwide, for the impact of his research on chemistry and industrial chemistry.


Key Publications

  1. J. Yang, Y.J. Wang, E. Ma, A. Zaccone, L.H. Dai, M.Q. Jiang.
    Structural parameter of orientational order to predict the boson vibrational anomaly in glasses.
    Physical Review Letters, accepted, in press.

  2. M. Lu, L. Banetta, L.J. Young, E.J. Smith, G.B.Bates, A. Zaccone, G. S. Kaminski-Schierle, A. Tunnacliffe, C. F. Kaminski.
    Live-cell super-resolution microscopy reveals a primary role for diffusion in
    polyglutamine-driven aggresome assembly.
    Journal of Biological Chemistry, accepted, in press.

  3. B. Cui, Z. Evenson, B. Fan, M. Li, W.-H. Wang, A. Zaccone.
    Possible origin of beta relaxation in amorphous metal alloys from atomic-mass differences of the constituents.
    Physical Review B 98, 144201 (2018).
  4. C. Eccles, S. Roy, T. H. Gray and A. Zaccone.
    Reply to 'Comment on "Temperature dependence of nuclear fission time in heavy-ion fusion-fission reactions"'.
    Physical Review C 98, 029802 (2018).

  5. V.V. Palyulin, C. Ness, R. Milkus, R.M. Elder, T.W. Sirk, A. Zaccone.
    Parameter-free predictions of the viscoelastic response of glassy polymers from nonaffine lattice dynamics.
    Soft Matter 14, 8475 (2018).

  6. J. Krausser, A. Lagogianni, K. Samwer, A. Zaccone.
    Reply to 'Comment on "Disentangling interatomic repulsion and anharmonicity in the viscosity and fragility of glasses"'.
    Physical Review B 98, 016202 (2018).

  7. B. Cui and A. Zaccone.
    Generalized Langevin Equation and fluctuation-dissipation theorem for particle-bath systems in external oscillating fields.
    Physical Review E 97, 060102(R) (2018).

  8. M. Dang, R. Zargar, D. Bonn, A. Zaccone, P. Schall. 
    Nonequilibrium free energy of colloidal glasses under shear
    Journal of Physics D: Applied Physics 51, 324002 (2018). 

  9. B. Cui, J. Gebbia, J.-L. Tamarit, A. Zaccone. 
    Disentangling alpha and beta relaxation in orientationally disordered crystals with theory and experiments.
    Physical Review E 97, 053001 (2018).

  10. G. M. Cicuta, J. Krausser, R. Milkus, A. Zaccone.
    Unifying model for random matrix theory in abritrary space dimensions.
    Physical Review E 97, 032113 (2018).

  11. V. Vetri, F. Piccirilli, J. Krausser, G. Buscarino, U. Lapinska, B. Vestergaard, A. Zaccone, V. Fodera'.
    Ethanol controls the self-assembly and mesoscopic properties of human insulin amyloid spherulites.
    Journal of Physical Chemistry B 122, 3101 (2018). 

  12. A. Zaccone.
    Harnessing entropy in single-molecule force spectroscopy with semiconducting polymers.
    Chem 4, 191-193 (2018).

  13. R. Milkus, C. Ness, V. Palyulin, J. Weber, A. Lapkin, A. Zaccone.
    Interpretation of the vibrational spectra of glassy polymers using coarse-grained simulations.
    Macromolecules 51, 1559–1572 (2018).

  14. R. Higler, J. Krausser, J. van der Gucht, A. Zaccone, J. Sprakel.
    Linking slow dynamics and microscopic connectivity in dense suspensions of charged colloids.
    Soft Matter 14, 780-788 (2018).

  15. L. Perez-Ocampo, A. Zaccone, M. Laurati.
    A well defined glass state obtained by oscillatory shear.
    Journal of Rheology 62, 197 (2018).

  16. C. S. Eccles, S. Roy, T. H. Gray, A. Zaccone.
    Temperature dependence of nuclear fission time in heavy-ion fusion-fission reactions.
    Physical Review C 96, 054611 (2017).

  17. A. Maestro and A. Zaccone.
    Nonaffine deformation and tunable yielding of colloidal assemblies at the air-water interface.
    Nanoscale 9, 18343 (2017).

  18. B Cui, J. Yang, J. Qiao, M. Jiang, L. Dai, Y.-J. Wang, A. Zaccone.
    Atomic theory of viscoelastic response and memory effects in metallic glasses.
    Physical Review B 96, 094203 (2017).

  19. C. Ness, V.V. Palyulin, R. Milkus, R. Elder, T. Sirk, A. Zaccone.
    Nonmonotonic dependence of polymer glass mechanical response on chain bending stiffness.
    Physical Review E (Rapid Communication) 96, 030501(R) (2017).

  20. J. Krausser, R. Milkus, A. Zaccone.
    Non-affine lattice dynamics of defective fcc crystals.
    Soft Matter 13, 6079 (2017).

  21. V. Hieronymus-Schmidt, H. Roesner, G. Wilde, A. Zaccone.
    Shear banding in metallic glasses described by alignments of Eshelby quadrupoles.
    Physical Review B 95, 134111 (2017).

  22. M. Abkenar, T. H. Gray, A. Zaccone.
    Dissociation rates from single-molecule pulling experiments under large thermal fluctuations or large applied force.
    Physical Review E 95, 042413 (2017).

  23. S.H. Varol, F. Meng, B. Hosseinkhani, C. Malm, D. Bonn, M. Bonn, A. Zaccone, S. H.  Parekh.
    Nanoparticle amount, and not size, determines chain alignment and nonlinear hardening in polymer nanocomposites.
    Proceedings of the National Academy of Sciences of the USA 114,
    E3170–E3177 (2017).

  24. C. Ness and A. Zaccone.
    Effect of hydrodynamic interactions on the lifetime of colloidal bonds.
    Industrial & Engineering Chemistry Research 56 (13), 3726–3732 (2017).

  25. J. Krausser, A. Lagiogianni, K. Samwer, A. Zaccone.
    Disentangling interatomic repulsion and anharmonicity in the viscosity and fragility of glasses.
    Physical Review B 95, 104203 (2017).

  26. J. Sprakel, A. Zaccone, F. Spaepen, P. Schall, D. A. Weitz.
    Direct observation of entropic stabilization of bcc crystals near melting.
    Physical Review Letters 118, 088003 (2017).

  27. B. Cui, R. Milkus, and A. Zaccone.
    Direct link between boson-peak modes and dielectric alpha-relaxation in glasses.
    Physical Review E 95, 022603 (2017).

  28. R. Milkus and A. Zaccone.
    Atomic-scale origin of dynamic viscoelastic response and creep in disordered solids.
    Physical Review E 95, 023001 (2017).

  29. M. Laurati, P. Masshoff, K.J. Mutch, S.U. Egelhaaf, A. Zaccone.
    Long-lived neighbors determine the rheological response of glasses.
    Physical Review Letters 118, 018002 (2017).

  30. B. Cui, R. Milkus, A. Zaccone.
    The relation between stretched-exponential relaxation and the vibrational density of states in glassy disordered systems.
    Physics Letters A 381, 446 (2017).

  31. W.Y. Chen, L. Young, M. Lu, Meng, A. Zaccone, F. Ströhl, N. Yu, G. Kaminski Schierle, C. Kaminski.
    Fluorescence self-quenching from reporter dyes informs on the structural properties of amyloid clusters formed in vitro and in cells.
    Nano Letters 17, 143 (2017).

  32. A. Saric, T. Michaels, A. Zaccone, T.P.J. Knowles, D. Frenkel.
    Kinetics of spontaneous filament nucleation via oligomers: insights from theory and simulation.
    Journal of Chemical Physics 145, 211926 (2016).

  33. A. Zaccone, I. Terentjev, T. Herling, T.P.J. Knowles, A. Aleksandrova, E.M. Terentjev.
    Kinetics of fragmentation and dissociation of two-strand protein filaments: coarse-grained simulations and experiments.
    Journal of Chemical Physics 145, 105101 (2016).

  34. A. Lappala, A. Zaccone and E.M. Terentjev.
    Polymer glass transition occurs at the marginal rigidity point with z*=4.
    Soft Matter 12, 7330 (2016).

  35. A. Lagogianni, J. Krausser, Z. Evenson, K. Samwer, A. Zaccone.
    Unifying interatomic potential, g(r), elasticity, viscosity, and fragility of metallic glasses: analytical model, simulations, and experiments.
    Journal of Statistical Mechanics: Theory and Experiment 084001 (2016) - Special Issue on Structure in Glassy and Jammed Systems.

  36. B.O. Conchuir, C. Tarantini, C. McNeill, S. Huettner, A. Zaccone.
    Chain-assisted charge transport in semicrystalline conjugated polymers.
    Journal of Physical Chemistry C 120, 14539 (2016).

  37. M. Lattuada, A. Zaccone, H. Wu, M. Morbidelli.
    Population-balance description of shear-induced clustering, gelation and suspension viscosity in sheared DLVO  colloids.
    Soft Matter 12, 5313 (2016).

  38. R. Milkus and A. Zaccone.   
    Local inversion-symmetry breaking controls the boson peak in glasses and crystals.
    Physical Review B 93, 094204 (2016).       
  39. F. Mura and A. Zaccone.
    Effects of shear flow on phase nucleation and crystallization.
    Physical Review E 93, 042803 (2016).

  40. M. T. Dang, D. Denisov, B. Struth, A. Zaccone, P. Schall.
    Reversibility and hysteresis in the sharp yielding transition of colloidal glasses under oscillatory shear.
    European Physical Journal E 39, 44 (2016).

  41. M. Schlegel, J. Brujic, E. M. Terentjev, A. Zaccone.
    Local structure controls the nonaffine shear and bulk moduli of disordered solids.
    Scientific Reports (Nature) 6, 18724 (2016).

  42. K. Kyriakos, M. Philipp, C.-H. Lin, M. Dyakonova, M. Vishnevetskaya, I. Grillo, A. Zaccone, A. Miasnikova, A. Laschewski, P. Mueller-Buschbaum, C. Papadakis.
    Quantifying the interactions in the aggregation of thermoresponsive polymers - the effect of cononsolvency.
    Macromolecular Rapid Communications 37, 420 (2016).

  43. J. Krausser, K. Samwer, A. Zaccone.
    Interatomic repulsion softness directly controls the fragility of supercooled metallic melts.
    Proceedings of the National Academy of Sciences of the USA 112, 13762 (2015).

  44. D. Denisov, M.T. Dang, B. Struth, A. Zaccone, G. H. Wegdam, P. Schall.
    Sharp symmetry-change marks the mechanical failure transition of glasses.
    Scientific Reports (Nature) 5,  14359 (2015).

  45. M. Mermet-Guyennet, J. de Castro, S. Varol, M. Habibi, B. Hosseinkhani, N. Martzel, R. Sprik, M. Denn, A. Zaccone, S. Parekh, D. Bonn.
    Size-dependent reinforcement of composite rubbers.
    Polymer 73, 170 (2015).

  46. M. van der Linden, B. O. Conchuir, E. Spigone, A. Niranjan, A. Zaccone, P. Cicuta.
    Microscopic origin of the Hofmeister effect in gelation kinetics of colloidal silica.
    Journal of Physical Chemistry Letters 6, 2881 (2015).

  47. A. Zaccone, I. Terentjev, L. Di Michele, E. M. Terentjev.
    Fragmentation and depolymerization of non-covalently bonded filaments.
    Journal of Chemical Physics 142, 114905 (2015).

  48. S. Gu, J. Kaiserc, G. Marzuna, A. Ott, Y. Lu, M. Ballauff, A. Zaccone, S. Barcikowski, P. Wagener.
    Ligand-free gold nanoparticles as a reference material for kinetic modelling of catalytic reduction of 4-nitrophenol.
    Catalysis Letters 145, 1105 (2015).

  49. A. Zaccone, P. Schall, E. M. Terentjev.
    Microscopic origin of nonaffine nonlinear deformation in bulk metallic glasses.
    Physical Review B 90, 140203(R) (2014).

  50. S. Gu, S. Wunder, Y. Lu, M. Ballauff, R. Fenger, K. Rademann, B. Jaquet, A. Zaccone.
    Kinetic analysis of the catalytic reduction of 4-nitrophenol by metallic nanoparticles.
    Journal of Physical Chemistry C 118, 18618-18625 (2014).

  51. A. Zaccone, M. Siebenbürger, H. H. Winter, M. Ballauff.
    Linking self-assembly, rheology, and gel transition in attractive colloids.
    Journal of Rheology 58, 1219 (2014).

  52. B. O. Conchuir, Y.M. Harshe, M. Lattuada, A. Zaccone.
    Analytical model of fractal aggregate stability and restructuring in shear flows.
    Industrial & Engineering Chemistry Research 53, 9109 (2014).

  53. A. Zaccone and E.M. Terentjev.
    Short-range correlations control the G/K and Poisson ratios of amorphous solids and metallic glasses.
    Journal of Applied Physics 115, 033510 (2014).

  54. A. Moussa, M. Lattuada, B. O. Conchuir, A. Zaccone, M. Morbidelli, M. Soos.
    Flow-Induced aggregation and breakup of particle clusters controlled by surface nanoroughness.
    Langmuir 29, 14386 (2013).

  55. A. Lappala, A. Zaccone, E.M. Terentjev.
    Ratcheted diffusion through crowded nanochannels.
    Scientific Reports (Nature) 3, 3103 (2013).

  56. V. Fodera’, A. Zaccone, M. Lattuada, A.M. Donald.
    Electrostatics controls the formation of amyloid superstructures in protein aggregation.
    Physical Review Letters 111, 108105 (2013).

  57. A. Zaccone.
    Slowing-down of diffusion-controlled reactions in dense liquid matter.
    Journal of Chemical Physics 138, 186101 (2013).

  58. A. Zaccone and E. M. Terentjev.
    Disorder-assisted melting and the glass transition in amorphous solids.
    Physical Review Letters 110, 178002 (2013).

  59. B. O. Conchuir and A. Zaccone.
    Mechanism of flow-induced biomolecular and colloidal aggregate breakup.
    Physical Review E 87, 032310 (2013).

  60. A. Zaccone, J.J. Crassous, M. Ballauff.
    Colloidal gelation with variable attraction energy.
    Journal of Chemical Physics 138, 104908 (2013).

  61. A. Zaccone.
    Elastic deformations in covalent amorphous solids.
    Modern Physics Letters B 27, 1330002 (2013).

  62. T. Gibaud, A. Zaccone, E. Del Gado, V. Trappe, P. Schurtenberger.
    Unexpected decoupling of stretching and bending modes in protein gels.
    Physical Review Letters 110, 058303 (2013).

  63. L. DiMichele, A. Zaccone, and E. Eiser.
    Predictive theory of polymer-network mediated attraction between colloid particles.
    Proceedings of the National Academy of Sciences of the USA 109, 10187 (2012).

  64. A. Zaccone and E.M. Terentjev.
    Theory of molecular crowding in Brownian hard-sphere liquids.
    Physical Review E 85, 061202 (2012).

  65. A. Zaccone and E.M. Terentjev.
    Theory of thermally-activated ionization and dissociation of bound states.
    Physical Review Letters 108, 038302 (2012).

  66. A. Zaccone, J.R. Blundell, and E.M. Terentjev.
    Network disorder and nonaffine deformations in marginal solids.
    Physical Review B 84, 174119 (2011).

  67. A. Zaccone, J.J. Crassous, B. Beri, and M. Ballauff.
    Quantifying the reversible association of thermoresponsive nanoparticles.
    Physical Review Letters 107, 168303 (2011).

  68. A. Zaccone, N. Dorsaz, C. DeMichele, F. Piazza, M. Morbidelli, and G. Foffi.
    Crowding, intermolecular interactions and shear-flow effects in the diffusion model of chemical reactions.
    Journal of Physical Chemistry B 115, 7383 (2011).

  69. A. Zaccone and E. Scossa-Romano.
    Approximate analytical description of the nonaffine response of amorphous solids.
    Physical Review B 83, 184205 (2011).

  70. A. Zaccone, D. Gentili, H. Wu, M. Morbidelli, and E. Del Gado.
    Shear-driven solidification of dilute colloidal suspensions.
    Physical Review Letters 106, 138302 (2011).

  71. D. Xie, H. Wu, A. Zaccone, L. Braun, and M. Morbidelli.
    Criticality for shear-induced gelation of charge-stabilized colloids.
    Soft Matter 6, 2692 (2010).

  72. A. Zaccone, D. Gentili, H. Wu, and M. Morbidelli.
    Shear-induced reaction-limited aggregation kinetics of Brownian particles at arbitrary concentrations.
    Journal of Chemical Physics 132, 134903 (2010).

  73. H. Wu, E. Tsoutsoura, M. Lattuada, A. Zaccone, and M. Morbidelli.
    Effect of temperature on high shear-induced gelation of charge-stabilized colloids without adding electrolytes.
    Langmuir 26, 2761 (2010).

  74. A. Zaccone and E. Del Gado.
    On mean coordination and structural heterogeneity in model amorphous solids.
    Journal of Chemical Physics 132, 024906 (2010).

  75. A. Zaccone, H. Wu, and E. Del Gado.
    Elasticity of short-ranged attractive colloids: homogeneous and heterogeneous glasses.
    Physical Review Letters 103, 208301 (2009).

  76. A. Zaccone, H. Wu, D. Gentili, and M. Morbidelli.
    Theory of activated-rate processes under shear with application to shear-induced aggregation of colloids.
    Physical Review E 80, 051404 (2009).

  77. A. Zaccone.
    The shear modulus of metastable amorphous solids with strong central and bond-bending interactions.
    Journal of Physics: Condensed Matter 21, (28) 285103 (2009).

  78. A. Zaccone, M. Soos, M. Lattuada, M. U. Bäbler, and M. Morbidelli.
    Breakup of dense colloidal aggregates under hydrodynamic stresses.
    Physical Review E 79, 061401 (2009).

  79. H. Wu, A. Zaccone, E. Tsoutsoura, M. Lattuada, and M. Morbidelli.
    High shear-induced gelation of charge-stabilized colloids in a microchannel without adding electrolytes.
    Langmuir 25, 4715 (2009).

  80. A. Zaccone, H. Wu, Portaluri, M. Lattuada, and M. Morbidelli.
    Mechanically stirred single-stage column for continuous gelation of colloidal systems.
    AIChE Journal 54, 3106 (2008).

  81. A. Zaccone, H. Wu, M. Lattuada, and M. Morbidelli.
    Charged molecular films on Brownian particles: structure, interactions and relation to stability.
    Journal of Physical Chemistry B 112, 6793 (2008).

  82. A. Zaccone, H. Wu, M. Lattuada, and M. Morbidelli.
    Correlation between surfactant adsorption/association phenomena and colloidal stability studied by light scattering.
    Journal of Physical Chemistry B 112, 1976 (2008).

  83. A. Zaccone, M. Lattuada, H. Wu, and M. Morbidelli.
    Theoretical elastic moduli for disordered packings of interconnected spheres.
    Journal of Chemical Physics 127, 174512 (2007).

  84. A. Zaccone, A. Gäbler, S. Maaß, D. Marchisio, and M. Kraume.
    Drop breakage in liquid-liquid stirred dispersions - Modelling of single drop breakage.
    Chemical Engineering Science 62, 6297-6307 (2007).

  85. S. Maass, A. Gäbler, A. Zaccone, A. Paschedag, and M. Kraume.
    Experimental investigations and modelling of breakage phenomena in stirred liquid/liquid systems.
    Chemical Engineering Research & Design 85, 703 (2007).


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