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Dr Jonathan James Phillips

Dr Jonathan James Phillips

Senior Research Associate

Structural dynamics of molecular systems.

Therapeutic protein design, engineering and development.

Structural mass spectrometry.

Hydrogen/deuterium-exchange (HDX).

Mathematical and structural modelling and simulation.

Statistical mechanics of protein molecules.

Office Phone: 334764

Other Professional Activities

Member of the CEB-MedImmune partnership: The Beacon Project.


  • biochemical engineering
  • Biosensors
  • drug delivery
  • biopharmaceuticals
  • Simulation
  • pharmaceuticals
  • Chemical Sensing
  • biosensors
  • analytical biotechnology
  • Sensor

Key Publications

Millership C.M.*, Phillips J.J.* and Main E.R.G. (2016) Ising Model Reprogramming of a Repeat Protein's Equilibrium Unfolding Pathway. J. Mol. Biol. (In Press) Fulltext DOI: 10.1016/j.jmb.2016.02.022

Edgeworth MJ, Phillips JJ, Lowe D, Kippen AD, Higazi DR and Scrivens JH. (2015) Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability. Angew. Chem. Int. Ed. 54. Fulltext DOI: 10.1002/anie.201507223

Klein T*, Vajpai N*, Phillips JJ*, Davies G, Holdgate GA, Phillips C, et al. Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase. (2015) Nature Communications 6:7877. Fulltext DOI: 10.1038/ncomms8877.

Tavakoli-Keshe R., Phillips J.J., Turner R. and Bracewell, D. (2013) Understanding the relationship between biotherapeutic protein stability and solid/liquid interfacial shear in constant region mutants of IgG1 and IgG4. J. Pharm. Sci. 103: 437–444. Fulltext DOI: 10.1002/jps.23822

Main E.R.G., Phillips J.J. and Millership C.M. (2013) Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks. Biochem. Soc. Trans., 41(5): 1152-1158 Fulltext DOI: 10.1042/BST20130102

Phillips J.J., Millership C. and Main E.R.G. (2012), Fibrous nanostructures from the self-assembly of designed repeat protein modules. Angew. Chem. Int. Ed., 51: 13132–13135. Fulltext DOI: 10.1002/anie.201203795

Phillips J.J., Javadi Y., Millership C. and Main E.R.G. (2012), Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors. Protein Science, 21: 327–338. Fulltext DOI: 10.1002/pro.2018

Phillips J.J., Yao Z.P., Zhang W., McLaughlin S., Laue E.D., Robinson C.V., Jackson S.E. (2007) Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs. J. Mol. Biol., 372(1): 189–203. Fulltext DOI: 10.1016/j.jmb.2007.04.059

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