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Department of Chemical Engineering and Biotechnology

 

Biography

Dr. Patra is a senior researcher working as EU Horizon 2020 Marie Curie Individual European Fellow (2017-2019) for his recent proposal ‘NinZA’ on theranostic nanomedicine to overcome drug resistance and is now working at CEB. Dr. Patra has also invented a NIR label free imaging technique to study such dynamics at nano-scale and recently filed 4 patents (US and PCT) in the area. He has degrees in Chemistry (BSc) and Biochemistry (MSc, PhD) and during his training, he spent research stays at the Department of Physics of University of Wisconsin at Milwaukee in USA, and at the Micro-Nanotechnology Department of Hosei University, and the Department of Immunology and Microbiology of Nihon University Medical School, both in Tokyo, Japan. Dr. Patra has been selected in prestigious 64th Lindau Nobel Laureate Meeting through a global competition, in Lindau, Germany. He is engaged in active editorial process to the journal Biosensors and Bioelectronics (Elsevier, UK), Frontiers in Biotechnology (Frontiers, Switzerland) and recently edited three books on 'Advanced Theranostic Materials', 'Advanced Bioelectronics Materials' and ‘Advanced Materials Interfaces’ with Wiley-Scrivener. His long-term research goal is to lead an international academic team on ‘Translational Theranostics’, designing nano-architectures for early stage probing, site-specific therapeutics and systemic theranostics for regenerative medicine and chronic diseases.

Research

Publications

Key publications: 
  1. Hirak K Patra*, Mohammad Azharuddin, Mohammad M. Islam, Georgia Papapavlou, Geyunjian Harry Zhu, Suryyani Deb, Thobias Romu, Ashis K. Dhara, Mohammad Javari, Amineh Gadheri, Jorma Hinkula, Madhavan R Rajan, Nigel Slater. Rational nanotoolbox with theranostic potential for medicated pro-regenerative corneal implants. Advanced Functional Materials, 2019, 1903760.
  2. Debarshi Banerjee, Geyunjian Harry Zhu, Artur Cieslar-Pobuda, Emilia Weichec and Hirak K Patra*. Adding nanotechnology to metastasis treatment arsenal. Trends in Pharmacological Science, 2019,  40(6), 403-418
  3. Mohammad Azharuddin, Debapratim Das, Lokman Uzun, Anthony P.F. Turner and Hirak K Patra*. A repertoire of biotechnological applications of noble metal nanocomposites. Chem. Comm. 2019, 55, 6964-6996. (Feature article)
  4. Souvik Bandyopadhyay, Mohammad Azharuddin, Anjan Dasgupta, Bhaswati Ganguli, Sugata Sen Roy, Hirak K Patra*, and Suryyani Deb. Probing ADP induced aggregation kinetics during platelet-nanoparticle interactions: Functional dynamics analysis to rationalize safety and benefits. Frontiers in Bioengineering and Biotechnology, 2019, 7:163.
  5. Arka Mukhopadhyay, Sankar Basu, Santiswarup Singha, and Hirak K Patra*. Inner-View of Nanomaterial Incited Protein Conformational Changes: Insights into Designable Interaction. Research, 2018, Volume 2018, 9712832, DOI: 10.1155/2018/9712832.
  6. Sanhita Ray, Sayantani Sen, Alakananda Das, Anirban Bose, Anirban Bhattacharyya, Avishek Das, Sanatan Chattopadhyay, Shib Shankar Singha, Achintya Singha, Hirak K Patra, & Anjan Dasgupta. Bioelectronics at Graphene Biofilm Interface: Schottky junction formation and capacitive transitions. Medical Devices & Sensors, 2018, 1(3):e10013.
  7. Yılmaz, Erkut, Bora Garipcan, Hirak K Patra, and Lokman Uzun. Molecular imprinting applications in forensic science. Sensors 17, 4 (2017): 691.
  8. R Ravichandran, C Astrand, Hirak K Patra, Anthony PF Turner, Véronique Chotteau, Jaywant Phopase. Intelligent ECM mimetic injectable scaffolds based on functional collagen building blocks for tissue engineering and biomedical applications. RSC Advances, 2017, 7, 21068-21078.
  9. Hirak K Patra, Yashpal Sharma, Mohammad Islam, Mohammad Javad Jafari, Arul Murugan, Hisatoshi Kobayashi, Anthony PF Turner, and Ashutosh Tiwari. Inflammation-sensitive in situ smart scaffolding for regenerative medicine. Nanoscale, 2016, 8 (39), 17213-17222.
  10. M. Griffith, M.M. Islam, J. Edin, G. Papapavlou, O. Buznyk and Hirak K Patra*. The quest for anti-inflammatory and anti-infective biomaterials in clinical translation. Frontiers in Bioengineering and Biotechnology. 2016, 4:71. doi: 10.3389/fbioe.2016.00071
  11. Azzouzi, S., Hirak K Patra, Ali, M. B., Abbas, M. N., Dridi, C., Errachid, A., & Turner, A. P. (2016). Citrate-selective electrochemical μ-sensor for early stage detection of prostate cancer. Sensors and Actuators B: Chemical, 2016, 228, 335-346.
  12. Hirak K Patra, Roghayeh Imani, Jaganmohan Jangamreddy, Meysam Pazoki, Aleš Iglič, Anthony Turner et al, On/off-switchable anti-neoplastic nanoarchitecture, Scientific Reports 2015, 5, 14571.
  13. Ghaderi, Amineh, Eduardo Antunez Mayolo, Hirak K Patra, Mohsen Golabi, Onur Parlak, Rickard Gunnarsson, Raul Campos et al. Keys and regulators of nanoscale theranostics. Adv. Mater. Lett 6 (2015): 87-98. (equal contributions)
  14. Hirak K Patra, Nisar Ul Khaliq, Thobias Romu et al, MRI-visual order-disorder micellar nanostructures for smart cancer theranostics, Advanced Healthcare Materials, 2014, 3(4) 526-535. (Nanowerk Spotlight)
  15. Hirak K Patra and Anthony PF Turner. The Potential Legacy of Nanotechnology: Cellular Selection. Trends in Biotechnology, 2014, 32(1) 21-31. (Cover Page & cover story)
  16. E. Farahani, Hirak K. Patra, Jaganmohan R., Iran Rashedi. Cell adhesion molecules and their relation to (cancer) cell stemness. Circinogenesis, 2014 35(4), 747-759.
  17. Hirak K Patra, Chan O Chey, Mattias Tengdelius et al, Impact of nanotoxicology towards technologists to end users Advanced. Materials Lett. 2013, 4, 591- 597. (Issue highlight)
  18. D. Mukherjee, Hirak K Patra, A Laskar et al. Cyclophilin-Mediated Reactivation Pathway of Inactive Adenosine Kinase Aggregates. Arch. of Biochem. Biophys, 2013, 537, 82-90.
  19. J. Sengupta, P. Datta, Hirak K Patra, et al. In Vivo Interaction of Gold Nanoparticles after Acute and Chronic Exposures in Experimental Animal Models. Journal of Nanoscience and Nanotechnology, 2013, 13(3), 1660-1670.
  20. Hirak K Patra and Anjan Kr. Dasgupta. Cancer Cell Response to Nanoparticles: Criticality and Optimality. Nanomedicine, 2012, 8(6), 842-852. (Issue Highlight & part of PhD thesis).
  21. D. Parial, Hirak K Patra, P. Roychoudhury, A. Kr. Dasgupta & R. Pal. Gold nanorod production by cyanobacteria - a green chemistry approach. J Appl Phycol. 2012, 24:55–60.
  22. D. Parial, Hirak K Patra, Anjan Kr. Dasgupta & Ruma Pal. Screening of different algae for green synthesis of gold nanoparticles, European Journal of Phycology, 2012, 47(1): 22-29.
  23. Hirak K Patra, Anjan kr. Dasgupta, S. Sarkar et al. Dual Role of Nanoparticles as Drug Carrier and Drug; Cancer Nanotechnology, 2011, 2: 37-47. (Part of PhD thesis).
  24. D. Sahoo, P.Bhattacharya, Hirak K Patra, P. Mandal, S. Chakravorti. Gold nanoparticle induced conformational changes in heme protein. J Nanoparticle Research. 2011, 13(12): 6755-6760.
  25. S. Deb, Hirak K Patra, P. Lahiri, A.K. Dasgupta, et al, Multistability in platelets and their response to gold nanoparticles. Nanomedicine, 2011, 7(4): 376-84. (Cover page & story)
  26. Hirak K Patra and Anjan Kr. Dasgupta. Arginine an enhancer of Gold nanoparticle induced Blocking of S-Phase cell cycle in HL60. Advanced Science Letter, 2011, 4: 3770-3775. (Part of PhD thesis). 
  27. Hirak K Patra, D. GuhaSarkara and Anjan Kr. Dasgupta, Multimodal electrophoresis of gold nanoparticles: A real time approach. Anal. Chimica Acta. 2009, 649:128–134. (spotlight in IUPAC meet 2009, Sanghai and Part of PhD thesis)
  28. Hirak K Patra, Subhojit Banerjee, Utpal Chaudhuri, Prabir lahiri & Anjan.Kr.Dasgupta. Cell Selective Response to Gold Nanoparticle. Nanomedicine. 2007, 3(2): 111-119. (Citation > 400) (Part of PhD thesis).
  29. U. Chatterjee, G. Mondal, P. Chakraborti, Hirak K Patra et al. Changes in the allergenicity during different as illustrated by ELISA and immunoblotting. Int. Arch Allergy Immunol. 2006; 141(1): 1-10.

Book Chapters

1.         A Mukhopadhyay and Hirak K Patra*. Nanomaterial—Live Cell Interface:Mechanism and Concern. Advanced Materials Interfaces, 2016, 11: 405–426. ISBN: 9781119242451

2.         A Mukhopadhyay and Hirak K Patra*. Nano-assisted Functional Modulation of Enzymes: Concept and Applications, Advanced Surface Engineering Materials. 2016: 7, 281-316.

3.         Deb, Suryyani, and Hirak K Patra. Cardiovascular Nanomedicine. In Advanced Theranostic Materials, pp. 159-182. John Wiley & Sons, Inc., 2015.

 

4.         Hirak K Patra, and Anjan Kr Dasgupta. Gold Nanostructures and their Applications in Diagnosis and Therapy of Cancer. In Nanotechnology: diagnosis and treatment of cancers (2012): 27-35.

 

Peer-reviewed conference contributions (results not published elsewhere):

1.         Hirak K Patra*. Sensible Label-Free Bio-Sensing: Towards in Situ Biopsy. 2018 IEEE SENSORS, doi: 10.1109/ICSENS.2018.8589723, 1-4

2.     Hirak K Patra*, Sergiy Valyukh, Emilia Wiechec, Ashutosh Tiwari, and Anthony Turner. "Switchable label free apta-nanosensor: In situ biopsy?" In Biosensors 2016–The World Congress on Biosensors, Gothenburg, Sweden, 25-27 May 2016. Elsevier, 2016.

3.  Hirak K Patra* and Anthony Turner. "Smart inflammation sensitive self-reporting theragnosis." In FEBS-EMBO 2014 Congress, 30 August-4 September 2014, Paris, France. 2014.

4.   Ozgur, Edogan, Hirak K Patra, Lokman Uzun, and Anthony Turner. "Smart polymerisable terbium (III) complex-based fluorescent MIP nanoparticles." In Biosensors 2016–The World Congress on Biosensors, Gothenburg, Sweden, 25-27 May 2016. Elsevier, 2016.

5.   Hirak K Patra, Roghayeh Imani, Ales Iglic, Anthony Turner, and Ashutosh Tiwari. "Novel anti-neoplastic approach for photodynamic theranostics by biocompatible TiO2 popcorn nanostructure for a high-throughput flash ROS generator." In 24th Anniversary World Congress on Biosensors–Biosensors 2014, 27-30 May 2014, Melbourne, Australia. Elsevier, 2014.

*Corresponding author/ significant scholarly impact

Editor:

1.       Advanced Theranostic Materials (2015). John Wiley & Sons, ISBN: 978-1-118-99829-8. The book covers the recent advances in the development on the regulation of theragnosis system and their biomedical perspectives to act as a future nanomedicine.

2.     Advanced Bioelectronics Materials (2015). John Wiley & Sons, Inc. ISBN: 978-1-118-99830-4. This book covers the recent advances in the development of bioelectronics systems and their potential application in future biomedical applications starting from system design to signal processing for physiological monitoring, to in situ biosensing.

3.    Advanced Material Interfaces (2016). John Wiley & Sons, Inc. ISBN: 978-1-119-24245-1. This book covers a state-of-the-art look at innovative methodologies and strategies adopted for interfaces and their applications.

 

Patents and IPs 

2017-present        Peptide Architectonics for biotherapeutics: [Docket no 64352, IPO]

Summary: We have invented a systemic approach and coined the term ‘Peptide architectonics’ (PA) which is the study of molecular architecture of peptides, specifically guided by a given context. PA can predict small native peptides and their derivatives that could generate a multifunctional platform to develop new therapeutic strategies to address biomedical problems. The process involves structural arrangement of an anatomical part of protein to achieve very specific function to stimulate and restore the function of the human physiological system. It is a novel form of therapeutic approach that uses body's natural molecular fragments/units that constitute the system and protect the body from harmful intrinsic side effects.

2012-present    Thermostable enzymes and methods: PCT/IB2012/000744 [2012, International]; US 13/991,605 [2012, US]; US9133450 B2 [2015, US]

Summary (Patent number: 9133450): Provided herein are compositions and methods for enhancing enzyme activity, half-life and/or thermostability and enhanced enzyme activities. Also provided herein are methods and compositions related to improved pectinolytic enzymes, such as pectate lyase, which exhibit enhanced activity, thermostability and/or longer half-life.

2011-present    NIR fluorescence of heavy water: [PCT/IB2011/000733[2011, International]; 196/KOL/2011 [2011, India]; 13/376,102 [2011, US]; US9354170 B2 [2016, US]

Summary (Patent number: 9354170): A method includes detecting D2O in a sample by fluorescence spectroscopy. The fluorescence spectroscopy may be near-infrared fluorescence spectroscopy. The method includes detecting D2O and D2O nano-clusters and their alterations in presence of suspended or colloidal objects including bio-molecules or cells, by emission spectroscopy.

2010-present    Label-free cell sorting: 13/123,209 [2011, USA]; PCT/IB2010/001954 [2010]

Summary: Disclosed methods and systems for identifying and sorting cells based on a near-infrared emission pattern of the cell in response to excitation at 630nm. The NIR emission pattern can be used for monitoring and sorting of cells in a label-free manner, and thus provides a positive method for selecting cells, such as stem cells, for use in therapy.

2009-present    Systems and methods employing giant stokes shift: 1076/KOL/2009 [2009, India]; PCT/IB2011/000733 [2011, International] 12/628,721[2009, USA, Published]

Summary: A method comprising exposing a sample comprising water to near infrared (NIR) light and detecting the presence of one or more objects by measuring a Stokes shift in the emission spectra in the near infrared.

 

 

Teaching and Supervisions

Research supervision: 

Co-Supervision (PhD student)

Geyunjian Harry Zhu

 

 

Mentor (PhD student) through Wolfson College doctoral students mentoring scheme:

Carlo Miguel C. Sandoval

Tao Luo

 

 

Supervisor (Part II Undergraduate Research Project)

Hashi Ibrahim-Hashi  (Clare College)

Raghav Manchanda 

Senior researcher
Dr Hirak K Patra

Affiliations

Collaborator profiles: 
Person keywords: 
protein engineering
biochemical engineering
Biosensors
drug delivery
biopharmaceuticals
superparamagnetic
MRI
nanoparticles
biosensors
nanoparticle synthesis
analytical biotechnology
pharamaceuticals