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Leonard Chia

Leonard Chia

PhD Candidate

Office Phone: 330144


MEng, Chemical Engineering, Imperial College London (2007)

Research Engineer, Formulation Science, Department of Crystallisation and Particle Science, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), Singapore (2007-2012)

A*STAR Graduate Scholarship (Overseas) - A*STAR - University of Cambridge Partnership

Research Interests

Structured Materials

  1. Drug Delivery
  2. Pulmonary delivery
  3. Controlled release
  4. Solid state characterisation
  5. Particle engineering
  6. Formulation science


  • drug delivery
  • powders
  • particle technology
  • microstructure
  • formulation
  • material characterisation
  • pharmaceutics

Key Publications

Journal Articles

  1. Hong S, Shen S, Tan DCT, Ng WK, Liu X, Chia LSO, Irwan AW, Tan R, Nowak SA, Marsh K, Gokhale R. High drug load, stable, manufacturable and bioavailable fenofibrate formulations in mesoporous silica: a comparison of spray drying versus solvent impregnation methods. Drug Deliv. 2014 [Early Online] doi: 10.3109/10717544.2014.913323
  2. Shen S-C, Ng WK, Chia LSO, Dong Y-C, Tan RBH. Preparation and application of monodispersed mesoporous submicron carbon particles as a drug carrier. Powder Technol. 2014 Jul; 261: 241-9. doi: 10.1016/j.powtec.2014.04.044
  3. Shen S-C, Ng WK, Chia LSO, Dong Y-C, Tan RBH. Applications of mesoporous materials as excipients for innovative drug delivery and formulation. Curr Pharm Des. 2013 Oct; 19(35): 6270-89. doi: 10.2174/1381612811319350005
  4. Shen S, Ng WK, Chia LSO, Dong Y, Tan RBH. Morphology controllable synthesis of nanostructured boehmite and γ-alumina by facile dry gel conversion. Cryst Growth Des. 2012 Oct; 12(10): 4987-94. doi: 10.1021/cg300915p
  5. Shen S-C, Ng WK, Shi Z, Chia L, Neoh KG, Tan RBH. Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery. J Mater Sci: Mater Med. 2011 Oct; 22(10): 2283-92. doi: 10.1007/s10856-011-4397-1
  6. Shen S-C, Ng WK, Chia L, Dong Y-C, Tan RBH. Sonochemical synthesis of (3-aminopropyl)triethyoxysilane-modified monodispersed silica nanoparticles for protein immobilization. Mater Res Bull. 2011 Oct; 46(10): 1665-9. doi: 10.1016/j.materresbull.2011.06.004
  7. Shen S-C, Ng WK, Chia L, Hu J, Tan RBH. Physical state and dissolution of ibuprofen formulated by co-spray drying with mesoporous silica: Effect of pore and particle size. Int J Pharm. 2011 May; 410(2): 188-95. doi: 10.1016/j.ijpharm.2011.03.018
  8. Chia L, Shen S, Ng WK, Tan RBH. Applications of mesoporous materials. Recent Pat Chem Eng. 2011 Apr; 4(1): 17-28. doi: 10.2174/2211334711104010017
  9. Shen SC, Chia L, Ng WK, Dong YC, Tan RBH. Solid-phase steam-assisted synthesis of hydroxyapatite nanorods and nanoparticles. J Mater Sci. 2010 Nov; 45(22): 6059-67. doi: 10.1007/s10853-010-4691-1
  10. Shen S-C, Ng WK, Chia L, Dong Y-C, Tan RBH. Stabilized amorphous state of ibuprofen by co-spray drying with mesoporous SBA-15 to enhance dissolution properties. J Pharm Sci. 2010 Apr; 99(4):1997–2007. doi: 10.1002/jps.21967
  11. Shen S-C, Ng WK, Zhong Z-Y, Dong Y-C, Chia L, Tan RBH. Solid-based hydrothermal synthesis and characterization of alumina nanofibers with controllable aspect ratios. J Am Ceram Soc. 2009 Jun; 92(6): 1311-6. doi: 10.1111/j.1551-2916.2009.03005.x

Book Chapters

  1. Shen SC, Ng WK, Chia L, Dong YC, Tan RBH. Synthesis, Properties, and Applications of Hydroxyapatite. In: Gshalaev VS, Demirchan AC, editors. Hydroxyapatite: Synthesis, Properties and Applications. Hauppauge: Nova Publishers; 2012. p. 165-214.
  2. Shen S, Dong Y-C, Ng WK, Chia L, Tan RBH. Nanocomposites for Drug Delivery. In: Kumar CSSR, editor. Nanocomposites. Weinheim: Wiley-VCH; 2010. p. 313-52. (Kumar CSSR, editor. Nanomaterials for the Life Sciences; Vol. 8)


  1. Shen SC, Ng WK, Chia L, Tan RBH, inventors; Agency for Science, Technology and Research, assignee. Nanostructured material formulated with bone cement for effective antibiotic delivery. United States patent application US 2012/0308633 A1. 2012 Dec 6; Singapore patent 181156. 2015 Jan 13.
  2. Shen SC, Ng WK, Chia L, inventors; Agency for Science, Technology and Research, assignee. Mesoporous material excipients for poorly aqueous soluble ingredients. United States patent US 8,778,401 B2. 2014 Jul 15; European patent application EP 2349336 A1. 2011 Aug 3; Singapore patent 170977. 2012 Apr 30.

Full list of publications on Google Scholar

Full list of publications on ResearcherID

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