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Department of Chemical Engineering and Biotechnology

 

The molecular pathology of Alzheimer’s disease by Eric Rees

Centre (grey) a differential interference contrast (DIC) image shows a cultured neuronal cell. Conventional fluorescence images (small red panels) indicate the existence of protein aggregates, but give no information on their size or morphology. Super-resolution images (top panels) clearly reveal the sharp fibrillar morphology of these protein aggregates, and reveal differences between structures found in the intra- and extracellular spaces, suggesting potential mechanisms for their growth and propagation. The molecular structure of a beta-Amyloid protein is illustrated, together with a stacking sequence by which it can form fibrils, in the lower part of the Figure.

Latest news

Nanoparticles used to transport anti-cancer agent to cells

16 September 2019

Researchers from our Adsorption and Advanced Materials group have developed a platform that uses nanoparticles known as metal-organic frameworks to deliver a promising anti-cancer agent to cells.

August paper of the month: Ultralow-field nuclear magnetic resonance of liquids confined in ferromagnetic and paramagnetic materials

16 September 2019

Researchers from our department’s magnetic resonance research centre show new insight provided by ultra-low-field techniques.

Our MPhil in Biotechnology wraps up a successful first year

4 September 2019

Our MPhil in Biotechnology 2018-19 course came to an official close last week with their first student cohort presenting their work at the course symposium.