skip to content

Department of Chemical Engineering and Biotechnology


9. Fourier spectrum of a two-colour TIRF-SIM super-resolution reconstruction of amyloid fibrils by Florian Stroehl

Amyloid fibrils are associated with Alzheimer's disease but are too small to be imaged clearly in a conventional microscope. A clever way to nevertheless observe them is by using super-resolution imaging like TIRF-SIM. In this technique several images of the fibrils are taken under different illumination patterns, each of which provides additional bits of resolution information. These bits are then combined via a computational reconstruction process that results in the cloverleaf-like spectrum shown . To obtain the final super-resolved image of the fibrils, this spectrum must be Fourier back-transformed.

The raw data for this image was taken on the custom built TIRF-SIM microscope of the Laser Analytics Group.

Latest news

Africans in STEM conference: opportunities and challenges

15 July 2019

The first Africans in STEM symposium held on 28 June 2019 in our department was aimed at celebrating African voices and ideas in STEM.

Annual conference highlights diverse impact of department research

4 July 2019

Our department Research Conference took place from 25-26 June, bringing together researchers from across the department, wider university, external institutions and industry.

Dr Janire Saez awarded Marie Curie Fellowship

14 June 2019

Dr Janire Saez awarded Marie Curie Fellowship for her work on organ-on-chip devices for cancer research.