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Best paper at ISB 2012

last modified Jan 29, 2014 10:17 AM
Best paper at ISB 2012

Best paper award

Dr Vassilios Vassiliadis and his co authors have received the prize for Best Paper at the Sixth IEEE International Conference on Systems Biology (ISB 2012). 

The title of the paper wasMetabolite Biomarker Discovery for Metabolic Diseases By Flux Analysisand the authors are Limin Li, Hao Jiang, Wai-Ki Ching, and Vassilios Vassiliadis.

The conference was organized by the Chinese Academy of Sciences and Xidian University and was held in Xi'an, China, on August 18-20, 2012.

Metabolites can serve as biomarkers of metabolic diseases, and their identification is significant in the study of biochemical reaction signalling networks. The paper presents an approach to identify metabolic biomarkers through integration of biomedical data and disease-specific gene expression data. An optimization approach was used to determine flux variability intervals leading to the identification of significant metabolic reactions. The corresponding metabolites were then compared to results in the existing literature. The approach proposed in this work is general and can be applied to the discovery of potentially novel biomarkers in biomedical research. 

The work is led by Professor Ching's group at Hong Kong University and Dr Vassiliadis of the PSE group in the Department was invited to participate in the paper following recent collaborative efforts between the two research groups.  Among many topics of common interest that were identified was also the case of Biochemical Reaction Networks. Professor Wai-Ki Ching was a visitor of the PSE group in our Department in July of 2012, exploring options with Dr. Vassiliadis for collaboration in applied mathematical methods and optimization.  He is Associate Professor of Applied Mathematics at Hong-Kong University.