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Biomolecular Conjugation and Structuring

This sub-project is focused on development of strategies to prepare DNA and protein conjugates for applications in DNA directed immobilisation and structuring, and use of natural DNA for design optoelectronic devices.

Selected examples:




Conjugation of short DNA strands to different proteins through tyrosine amino acids using click chemistry.

D. Bauer et al., Bioconj. Chem. 2013





Immobilisation of protein-DNA conjugates to DNA modified surfaces through DNA directed immobilisation 

 D. Bauer et. al. Chem. Commun. 2014




Silver nanoparticles were grown within the film composed of salmon sperm DNA and surfactant by irradiation of silver salt and photoinitiator.

Once the light is applied to the matrix embedded within two electrodes,nanoparticles are grown and there is a switching effect to high conductivity: this is the basis of write-once-read-many-times optical storage device.

This work is done in collaboration with the group of Yu-Chueh Hung, Tsing Hua University, Taiwan

Y-C.Hung et al., Appl. Phys. Lett. 2011

C-Y. Hung et al., J. Appl. Phys., 2015