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mng pictures

Tau

Tau

Tau (red), a protein involved in Alzheimer’s disease, co-localises with vesicular markers (green), informing us on the fate of Tau after internalisation by primary neurons in culture. The typical size of a vesicle is indicated by the white dashed lines. Scale bar: 500nm.

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Microfluidic

Microfluidic

A microfluidic-engineered cell culture chamber allows us to monitor separately “donor neurons”, axons and “acceptor neurons” in our study of Tau misfolded state propagation from cell to cell.

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PolyQ

PolyQ

A cell expressing polyQ (red), an aggregsome deposits next to microtubule-organising centre (MTOC, green).

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TEM_Huntingtin

TEM_Huntingtin

TEM image of amyloid fibrils formed from purified HTT exon 1 fusion protein.

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