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Department of Chemical Engineering and Biotechnology


Sibik, J., Sargent, M.J.,  Franklin, M., and Zeitler, J.A., (2014) Crystallisation and phase changes in paracetamol from the amorphous solid to the liquid phase, Molecular Pharmaceutics, 11, 1326–1334.

Chen, C. , Gladden, L.F. and Mantle, M.D. (2014) Direct visualization of in vitro drug mobilization from Lescol XL tablets using two-dimensional 19F and 1H magnetic resonance imaging, Mol. Pharmaceutics, 11, 630–637.

Li, C., Zeitler, J.A., Y. Dong, Y. and Shen, Y.-C. (2014) Nondestructive evaluation of polymer coating structures on pharmaceutical pellets using full field optical coherence tomography, J. Pharm. Sci., 103, 161-166.

Lau, C.L.S., Yu, Q., Lister, V.Y.L., Rough, S.L. and Wilson, D.I. (2014) The evolution of pellet size and shape during spheronisation of an extruded microcrystalline cellulose paste, Chem. Eng. Res. Des., in press.

Bawuah, P., Mendia, A., Silfsten, P., Pääkkönen, P., Ervasti, T., Ketolainen, J., Zeitler, J.A., and Peiponen, K.-E. (2014) Detection of porosity of pharmaceutical compacts by terahertz radiation transmission and light reflection measurement techniques, Intl. J. Pharm., 465, 70-75.

Zhang, M., Wilson, D.I., Ward, R., Seiler, C. and Rough, S.L. (2013) A comparison of screen and ram extrusion-spheronisation of simple pharmaceutical pastes based on microcrystalline cellulose, Intl. J. Pharm., 456, 489-498.

Mantle, M.D. (2013) NMR and MRI studies of drug delivery systems, Current Opinion in Colloid & Interface Science, 18, 214–227.

Brock, D.,  Zeitler, J.A., Funke, A., Knop, K. and Kleinebudde, P. (2013) Evaluation of critical process parameters for intra-tablet coating uniformity using terahertz pulsed imaging, Eur. J. Pharmaceutics Biopharmaceutics, 85, 1122-1129.

Zhang, M., Mascia, S., Rough, S.L., Ward, R., Seiler, C. and Wilson, D.I. (2013) A novel lab-scale screen extruder for studying extrusion-spheronisation, Intl. J. Pharm. 455, 285– 297.

May, R.K. Su, K., Han, L., Zhong, S., Elliott, J.A., Gladden, L.F., Evans, M., Shen, Y.C. and Zeitler, J.A. (2013) Hardness and density distributions of pharmaceutical tablets measured by terahertz pulsed imaging, J. Pharm. Sci., 102, 2179-2186.

Di Pretoro, G., Zema, L., Palugan, L., Rough, S.L., Wilson, D.I., and Gazzaniga, A. (2012) Optimisation and scale-up of a highly-loaded 5-ASA multi-particulate dosage form using a factorial approach. European J. Pharm. Sci.45, 158–168.

Mantle, M.D. (2011) Quantitative magnetic resonance micro-imaging methods for pharmaceutical research, Intl. J. Pharm., 417, 173–195.

Zhang, Q., Gladden, L.F., Avalle, P. and Mantle, M.D. (2011) In vitro quantitative 1H and 19F nuclear magnetic resonance spectroscopy and imaging studies of fluvastatin™ in Lescol® XL tablets in a USP-IV dissolution cell, J. Controlled Release, 156, 345–354.

Chen, Y.Y., Hughes, L.P., Gladden, L.F. and  Mantle, M.D. (2010) Quantitative ultra-fast MRI of HPMC swelling and dissolution, J. Pharm. Sci., 99, 3462-3472.

Laity, P.R., Mantle, M.D.Gladden, L.F. and Cameron, R.E. (2010) Magnetic resonance imaging and X-ray microtomography studies of a gel-forming tablet formulation, Eur. J. Pharm. Biopharm., 74, 109–119.

Noorsal, K., Mantle, M.D., Gladden, L.F. and Cameron, R.E. (2005) Degradation and drug-release studies of a poly(glycolide-co-trimethylene carbonate) copolymer (Maxon), J. Applied Polymer Sci., 95, 475–486.

Milroy, G.E, Cameron, R.E., Mantle, M.D., Gladden, L.F. and Huatan, H. (2003) The distribution of water in degrading polyglycolide. Part II: Magnetic resonance imaging and drug release, J. Matl. Sci: Matl. Medicine, 14, 465-473.