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Sustainable Reaction Engineering group

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Group leader: Professor Alexei Lapkin

Contact: aal35_at_cam.ac.uk

Group members: Dr John Suberu, Dr Polina Yaseneva, Dr Parminder Kaur Heer, Mr Samson M. Aworinde, Mr Philipp-Maximilian Jacob, Mr Jacek Zakrzewski, Mr Yehia Amar, Mr Nicholas Jose.

Visiting members of the group: Ms Jana Weber (RWTH-Aachen), Mr Danilo Russo (UNINA).  

A sustainable society will be built upon manufacturing processes that satisfy key criteria of resolving societal needs in the ways that do not deplete resources and do not harm the environment.

In order to understand implications of a given technology (or a manufacturing process) on resources and on the environment we need to place it within the context of a wider system. Thus, if we are considering a single reaction step, we need to understand also the complete process, including any separation requirements and sources/destinations of feedstocks and products/byproducts. If we are considering whether a given chemical product is better sourced from a renewable biofeedstocks, or from a petrochemical source, then we need to understand the supply chain and life cycle environmental implications of such a substitution. 

Sustainable Reaction Engineering group is developing new reactor concepts based on intensive reaction conditions, novel materials, sensor and control strategies. We are working with both, petrochemical and renewable biofeedstocks supply chains, and are interested in whole process design and sustainability assessment.

In the light of growing sustainability concerns the possibility of deriving many of the end-use molecules from biomass is receiving increasing attention. One of the key challenges encountered here is the choice of starting materials, target molecules and processing routes, making treatment very expensive computationally and highly uncertain from the point of view of business and technology development. Within the EPSRC funded collaborative project on the terpene-based supply chain, let by University of Bath and involving University of Bristol and Institute for Manufacturing at Cambridge, we are looking at methods of optimising different process scenarios based on several potential synthetic pathways.

The group recently completed the Horizon 2020 project "MEASURE" (www.spire2030.eu/measure). This was a coordination and support action (CSA) project, which aimed to develop a roadmap towards  harmonised cross-sectorial sustainability assessment in the European process industries. The project was coordinated by Friedrich-Schiller-Universität Jena (Dr Dana Kralisch) and also included Universities of Manchester and Ghent, Technische Universität Berlin, Evonik Industries, Procter & Gamble Services Company and ThyssenKrupp Steel Europe. The roadmap is now available on the project web page.

Together with Dr Andrew Flewitt and Prof. Richard Prager (Engineering) and Dr Cate Ducati (Materials and Metallurgy) we are involved in Horizon 2020 project "RECOBA" (www.spire2030.eu/recoba). This project is coordinated by BASF. The project is developing new control strategies for batch processes in several process industries sectors: polymers, steel and silicon. Our team is involved in developing and testing sensors for detection of soft particles morphology under process conditions.

Within Catalysis@Cambridge research network we are working together with Prof. Matthew Gaunt group on developing scalable continuous flow C-H activation reactions. We are also continuing the work on Design of Experiments algorithms for developing complex organic syntheses.

 

 

 

Publications from Sustainable Reaction Engineering group

2016

P.-M. Jacob, P. Yamin, C. Perez-Storey, M. Hopgood, and A.A. Lapkin, Towards automation of chemical process route selection based on data mining, Green Chem., (2016) 10.1039/C6GC02482C.

X. Fan,  V. Sans,  S.K. Sharma,  P.K. Plucinski,  V.A. Zaikovskii,  K. Wilson, S. R. Tennison,  A. Kozynchenko,  A.A. Lapkin, Pd/C catalysts based on synthetic carbons with bi- and tri-modal pore-size distribution: applications in flow chemistry, Catal. Sci. Technol., 6 (2016) 2387-2395. DOI: 10.1039/c5cy01401h

J. Zakrzhewski, A.P. Smalley, M. Kabeshov, A. Lapkin, M. Gaunt, Continuous flow synthesis and derivatization of aziridines via palladium-catalyzed C(sp3)-H activation, Angew. Chem. Int. Ed., 55 (2016) 8878-8883. DOI: 10.1002/anie.201602483

X. Fan, F. Xing, X. Ou,G.A. Turley, P. Denissenko, M.A. Williams, N. Batail, C. Pham, A.A. Lapkin,Microtomography-based numerical simulations of heat transfer and fluid flow through β-SiC open-cell foams for catalysis, Catal. Today (2016) http://dx.doi.org/10.1016/j.cattod.2015.12.012

P. Yaseneva, P. Hodgson, J. Zakrzewski, S. Falss, R.E. Meadows, A.A. Lapkin, Continuous flow Buchwald-Hartwig amination of a pharmaceutical intermediate, React. Chem. Eng., 1 (2016) 229-238. DOI: 10.1039/c5re00048c.

S. Falß, G. Tomaiuolo,A. Perazzo, P. Yaseneva,J. Zakrzewski,S. Guido,A. Lapkin, R. Woodward, R.E. Meadows, A Continuous Process for Buchwald-Hartwig Amination at Micro- Lab- and Multi-Kilo Scale, Org. Proc. Res. Des. 20(2) (2016) 558-567. DOI: 10.1021/acs.oprd.5b00350

J. Suberu, P. Yamin, R. Cornell, A. Sam, A. Lapkin, Feasibility of using 2,3,3,3-tetrafluoropropene (R1234yf) as a solvent for solid-liquid extraction of biopharmaceuticals, ACS Sustainable Chem. Eng. 4 (2016) 2559-2568. DOI: 10.1021/acssuschemeng.5b01721.

J. Suberu, P.S. Gromski, A. Nordon, A. Lapkin, Multivariate data analysis and metabolic profiling of artemisinin and related compounds in high yielding varieties of Artemisia annua field-grown in Madagascar, J. Pharmaceutical and Biomed. Analysis, 117 (2016) 522-531. doi:10.1016/j.jpba.2015.10.003

A. Lapkin, P.-M. Jacob, P. Yaseneva, C. Gordon, A. Peace, Assessment of sustainability within holistic process design, in Sustainability Assessment of Renewables-Based Products: Methods and Case Studies“, Eds. J. Dewulf, S.D. Meester, R. Alvarenga., Wiley. 2016

2015

C. Houben, G. Nurumbetov, D. Haddleton, A.A. Lapkin,Feasibility of simultaneous determination of monomer concentrations and particle size in emulsion polymerization using in situ Raman spectroscopy, Ind. Eng. Chem. Res. 54 (2015) 12867-12876.

C. Houben, A. Lapkin, Automatic discovery and optimisation of chemical processes, Curr. Opinion in Chem. Engng., 9 (2015) 1-7.

C. Houben, N. Peremezhney, A. Zubov, J. Kosek, A.A. Lapkin, Closed-loop multi-target optimisation for discovery of new emulsion polymerisation recipes, Org. Process Res. Dev., 19 (2015) 1049-1053.

C. Schotten, D. Plaza, S. Manzini, S.P. Nolan, S.V. Ley, D.L. Browne, A. Lapkin, Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride, ACS Sust. Chem. Eng., 3 (2015) 1453-1459.

P. Yaseneva, D. Plaza, X. Fan, K. Loponov, A. Lapkin, Synthesis of the antimalarial API artemether in a flow reactor, Catal. Today, 239 (2015) 90-96.

L. Torrente-Marciano, D. Nielsen, R. Jackstell, M. Beller, K. Cavell, A. Lapkin, Selective telomerisation of isoprene with methanol by a heterogeneous palladium resin catalyst. Catal. Sci. Technol., 5 (2015) 1206-1212. DOI: 10.1039/c4cy01320d.

A. Martinez-Lombardia, J. Krinsky, I. Peñafiel, S. Castillón, K. Loponov, A. Lapkin, C. Godard, C. Claver, Heterogenization of Pd-NHC complexes onto a silica support and their application in the Suzuki-Miyaura coupling under batch and continuous flow conditions, Cat. Sci. Technol., 5 (2015) 310-319.

A. Lapkin, Green Extraction of Artemisinin from Artemisia annua  L, In “Green Extraction of Natural Products: Theory and Practice”, Eds. F. Chemat, J. Strube, Wiley-VCH, 2015.

2014

N. Peremezhney, E. Hines, A. Lapkin, C. Connaughton, Combining Gaussian processes, mutual information and a generic algorithm for multi-targeted optimisation of expensive-to-evaluate functions, Engineering Optimisation, 46 (2014) 1593-1607.

X. Fan, J. Restivo, J.J. Órfão, M.F.R. Pereira, A. Lapkin, The role of multi walled carbon nanotubes (MWCNTs) in catalytic ozonation of atrazine, Chemical Engineering Journal, 241 (2014) 66-76.

J.O. Suberu, P. Yamin, K. Leonhard, L. Song, S. Chemat, N. Sullivan, G. Barker, A. Lapkin, The effect of O-methylated flavonoids and other co-metabolites on the crystallisation and purification of artemisinin, J. Biotechnol., 171 (2014) 25-33.

A. Lapkin, E. Adou, B.N. Mlambo, S. Chemat, J. Suberu, A.E.C. Collis, A. Clark, G. Barker, Integrating medicinal plants extraction into a high-value biorefinery: an example of Artemisia annua L. Comptes Rendus - Chimie, 17 (2014) 232-241.

V. Sans, S. Glatzel, F.J. Douglas, D.A. Maclaren, A. Lapkin, L. Cronin, Non-equilibrium dynamic control of gold nanoparticle and hyperbranched nanogold assemblies, Chemical Science, 5 (2014) 1153-1157.

P. Yaseneva, C.F. Marti, E. Palomares, X. Fan, T. Morgan, P.S. Perez, M. Ronning, F. Huang, T. Yuranova, L. Kiwi-Minsker, S. Derrouiche, A.A. Lapkin, Efficient reduction of bromates using carbon nanofibre supported catalysts: experimental and a comparative life cycle assessment study, Chemical Engineering Journal, 248 (2014) 230-241.

L. Torrente-Murciano, D.J. Nielsen, K.J. Cavell, A.A. Lapkin, Tandem isomerization/telomerization of long chain dienes, Frontiers in Chemistry, 2 (2014) Article 37, 1-5, DOI: 10.3389/fchem.2014.00037.

N. Peremezhney, P.-M. Jacob, A. Lapkin, Alternative methods of processing bio-feedstocks in formulated consumer products design, Frontiers in Chemistry, 2 (2014) Article 26, 1-6, DOI: 10.3389/fchem.2014.00026.

J.O. Suberu, I, Romero-Canelón, N. Sullivan, A.A. Lapkin, G.C. Barker, Comparative cytotoxicity of artemisinin and cisplatin and their interactions with chlorogenic acids in MCF7 breast cancer cells, ChemMedChem, 9 (2014) 2791-2798.

K.N. Loponov, J. Lopes, M. Barlog, E.V. Astrova, A.V. Malkov, A.A. Lapkin, Optimization of a Scalable Photochemical Reactor for Reactions with Singlet Oxygen, Org.Proc.Res.Dev., 18 (2014) 1443-1454.

2013

J.O. Suberu, A.P. Gorka, L. Jacobs, P.D. Roepe, N. Sullivan, G.C. Barker, A.A. Lapkin, Anti-Plasmodial Polyvalent Interactions in Artemisia annua L. Aqueous Extract – Possible Synergistic and Resistance Mechanisms, PLOS One 8:11 (2013) e80790.

J. Suberu, L. Song, S. Slade, N. Sullivan, G. Barker, A. Lapkin, A rapid method for the determination of artemisinin and its biosynthetic precursors in Artemisia annua L. crude extracts, J. Pharmaceutical and Biomedical Analysis, 84 (2013) 269-277.

D. Haddleton, J. Burns, C. Houben, C. Waldron, A. Anastasaki and A. Lapkin, Poly(acrylates) via SET-LRP in a continuous flow reactor, Polymer Chemistry 4 (2013) 4809-4813, 10.1039/C3PY00833A.