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Department of Chemical Engineering and Biotechnology

 

Building Services Manager

Staff vacancies - Wed, 15/04/2026 - 01:00

The Department of Chemical Engineering and Biotechnology is seeking an experienced and proactive Building Services Manager to support the safe, efficient and reliable operation of its buildings and technical infrastructure.

Reporting to the Technical Operations Manager, you will take responsibility for the management of building fabric and engineering services across the Department, ensuring that teaching and research activities are supported by well-maintained, compliant and fit-for-purpose facilities. You will oversee planned and reactive maintenance, coordinate infrastructure and refurbishment projects, and act as the key departmental contact for works delivered by Estates Management and external contractors.

You will work closely with academic staff, technical teams and contractors to support building operations, maintenance activities and infrastructure developments. The role also includes responsibility for ensuring statutory compliance and safe systems of work, including permit-to-work processes, risk assessments and key areas such as water hygiene and fire safety.

You will have line management responsibility for the Building Services team, ensuring effective delivery of services, prioritisation of work and ongoing staff development. You will also act as a principal key holder, including participation in an on-call rota to respond to out-of-hours incidents.

The postholder must have degree/Level 6 vocational qualification in a relevant technical discipline or equivalent relevant practical experience together with a sound understanding of building services and facilities management in a complex environment. You will bring excellent organisational and problem-solving skills, technical knowledge across mechanical and/or electrical systems, and the ability to work collaboratively with a wide range of stakeholders.

The University offers a generous benefits package including 36 days of annual leave (inclusive of bank holidays), a competitive pension scheme and family-friendly policies.

We welcome applications from individuals who wish to be considered for flexible working arrangements.

We particularly welcome applications from women and candidates from a BME background for this vacancy as they are currently under-represented at this level in our School.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcome and can be directed to the Technical Operations Manager via hr@ceb.cam.ac.uk.

Please quote reference NQ49412 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Coordinator (Part Time, Fixed Term)

Staff vacancies - Wed, 15/04/2026 - 01:00

The BioNano Engineering group, headed by Prof. Ljiljana Fruk (fruk-lab.com), is looking for an outstanding part-time (18.25 hours per week) Research Coordinator to work alongside team members and international partners and deliver activities related to recently awarded Nanoflash grant. Nanoflash aims to deliver new generation treatment for eye diseases such as macular degeneration and retinis pigmentosa in collaboration with partners from Italy, Switzerland, and Belgium. This position is funded by European Innovation Council.

The BioNano Engineering group (https://www.fruk-lab.com) exploits bioinspired strategies to develop new processes and materials to address ongoing health and sustainability challenges. In particular, the group is focused on designing bio-nano hybrid materials that can be used for various biomedical applications such as drug delivery systems for hard-to-treat cancers, and improved diagnostic tools.

The group has 20 members including 5 postdoctoral researchers, 11 PhD students and a number of MPhil students and visitors.

In addition to the activities managing Nanoflash grant, the role-holder will also provide administrative support to assist in accelerating research activities of the group:

  • Carry out research grant administration. Ensure that timesheets are kept up to date, keep records of each grant, update website, monitor expenditure on active grants, process expenses in line with grant guidelines, liaise with members of the University Research Office, Departmental staff, Finance and HR on research grants related matters.

  • Provide secretarial/clerical support. Diary management, identify suitable dates, book meeting rooms, organise catering, invite participants, organise travel, accommodation and parking, create agenda, take minutes, circulate papers and agenda, and follow up on any action plans.

  • Oversee financial administration activity. Monitor resources and expenditure against budgets, process invoices, orders and expense claims, follow financial regulations, track expenditure, liaise with the Accounts Team to ensure that Department accounts are up to date, ensure efficiency and effectiveness of processes and procedures, develop and review processes as required.

Fixed-term: The funds for this post are available until 31 December 2029 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 30th of April 2026.

Please quote reference NQ49428 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Research Associate (Fixed Term)

Research vacancies - Wed, 15/04/2026 - 01:00

Applications are invited for a Research Assistant (pre-doctoral) or Research Associate (post-doctoral) to conduct world-leading research on Leveraging Ontological Knowledge with Argumentative Agentic AI to Accelerate Chemical Development under the direction of Prof Alexei Lapkin.

The project is a collaboration with Prof Francesca Toni from Imperial College London, Dr Antonio Rago from Kings College London and industrial collaborators within the AIChemy Hub (https://aichemy.ac.uk/). The successful candidate will focus on extending the ontological knowledge base of chemical process development and extending the simulation environment of process models, recently developed in the group of Prof. Lapkin based in Cambridge and in Singapore (in Cambridge Centre for Advanced Research and Education in Singapore).

The successful candidate will contribute to the development of reinforcement learning agents operating with the knowledge base and the simulation environment. The developed knowledge base will provide data for advanced argumentative agentic AI based on reinforcement learning being developed at Imperial College London and Kings College. The project will develop an approach of including ontological knowledge base and expert knowledge within a multi-agentic AI framework.

The post is based in the Department of Chemical Engineering and Biotechnology at the University of Cambridge. This is a leading department of Chemical Engineering among UK Universities. The successful applicant will join the Sustainable Reaction Engineering (SRE) research group, led by Prof Lapkin. The group is working on many aspects of transition towards sustainable chemistry, including digital transformation of R&D and manufacturing (lapkingroup.com).

The successful applicant will need to interact and collaborate with the other partners from Imperial College London, Kings College London and industry, as well as to engage with members of the AIchemy Hub, with expertise in AI and/or chemistry.

Duties and responsibilities

The position offers an exciting opportunity for conducting internationally leading and impactful research in chemical process development supported by AI. The postholder will be responsible for researching, shaping and delivering solutions based on chemical and process ontologies, the concept of knowledge graphs, simulation of models within Python environment, working in cloud computing environment and will be expected to submit publications to top-tier conferences and journals in Chemistry / Chemical Engineering and AI.

To apply for this position, you must have a strong background in chemical reaction engineering with a focus on first principles models and simulation using Python, and have experience in machine learning, for example, reinforcement learning, including a proven publication track-record, in at least two of the following areas, as well as ability and willingness to become familiar with the others: process modelling and simulation, machine learning, reinforcement learning, ontologies. You should also have:

  • A Master's degree (Research Assistant) or PhD degree (Research Associate) in chemical engineering or a related area.
  • Familiarity with advanced process modelling and simulation using first principles models.
  • Familiarity with machine learning, coding in Python.
  • Excellent communication skills and ability to work with others.
  • Ability to organise your own work and set priorities to meet deadlines.
  • Willingness to travel to conferences and meetings of the project and of the AIChemy Hubs.

Appointment at Research Associate level is dependent on having a PhD; those without a PhD will be appointed at Research Assistant level. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 10th of May 2026.

Please quote reference NQ49413 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Building Services Manager

Assistant staff vacancies - Wed, 15/04/2026 - 01:00

The Department of Chemical Engineering and Biotechnology is seeking an experienced and proactive Building Services Manager to support the safe, efficient and reliable operation of its buildings and technical infrastructure.

Reporting to the Technical Operations Manager, you will take responsibility for the management of building fabric and engineering services across the Department, ensuring that teaching and research activities are supported by well-maintained, compliant and fit-for-purpose facilities. You will oversee planned and reactive maintenance, coordinate infrastructure and refurbishment projects, and act as the key departmental contact for works delivered by Estates Management and external contractors.

You will work closely with academic staff, technical teams and contractors to support building operations, maintenance activities and infrastructure developments. The role also includes responsibility for ensuring statutory compliance and safe systems of work, including permit-to-work processes, risk assessments and key areas such as water hygiene and fire safety.

You will have line management responsibility for the Building Services team, ensuring effective delivery of services, prioritisation of work and ongoing staff development. You will also act as a principal key holder, including participation in an on-call rota to respond to out-of-hours incidents.

The postholder must have degree/Level 6 vocational qualification in a relevant technical discipline or equivalent relevant practical experience together with a sound understanding of building services and facilities management in a complex environment. You will bring excellent organisational and problem-solving skills, technical knowledge across mechanical and/or electrical systems, and the ability to work collaboratively with a wide range of stakeholders.

The University offers a generous benefits package including 36 days of annual leave (inclusive of bank holidays), a competitive pension scheme and family-friendly policies.

We welcome applications from individuals who wish to be considered for flexible working arrangements.

We particularly welcome applications from women and candidates from a BME background for this vacancy as they are currently under-represented at this level in our School.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcome and can be directed to the Technical Operations Manager via hr@ceb.cam.ac.uk.

Please quote reference NQ49412 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Coordinator (Part Time, Fixed Term)

Assistant staff vacancies - Wed, 15/04/2026 - 01:00

The BioNano Engineering group, headed by Prof. Ljiljana Fruk (fruk-lab.com), is looking for an outstanding part-time (18.25 hours per week) Research Coordinator to work alongside team members and international partners and deliver activities related to recently awarded Nanoflash grant. Nanoflash aims to deliver new generation treatment for eye diseases such as macular degeneration and retinis pigmentosa in collaboration with partners from Italy, Switzerland, and Belgium. This position is funded by European Innovation Council.

The BioNano Engineering group (https://www.fruk-lab.com) exploits bioinspired strategies to develop new processes and materials to address ongoing health and sustainability challenges. In particular, the group is focused on designing bio-nano hybrid materials that can be used for various biomedical applications such as drug delivery systems for hard-to-treat cancers, and improved diagnostic tools.

The group has 20 members including 5 postdoctoral researchers, 11 PhD students and a number of MPhil students and visitors.

In addition to the activities managing Nanoflash grant, the role-holder will also provide administrative support to assist in accelerating research activities of the group:

  • Carry out research grant administration. Ensure that timesheets are kept up to date, keep records of each grant, update website, monitor expenditure on active grants, process expenses in line with grant guidelines, liaise with members of the University Research Office, Departmental staff, Finance and HR on research grants related matters.

  • Provide secretarial/clerical support. Diary management, identify suitable dates, book meeting rooms, organise catering, invite participants, organise travel, accommodation and parking, create agenda, take minutes, circulate papers and agenda, and follow up on any action plans.

  • Oversee financial administration activity. Monitor resources and expenditure against budgets, process invoices, orders and expense claims, follow financial regulations, track expenditure, liaise with the Accounts Team to ensure that Department accounts are up to date, ensure efficiency and effectiveness of processes and procedures, develop and review processes as required.

Fixed-term: The funds for this post are available until 31 December 2029 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 30th of April 2026.

Please quote reference NQ49428 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Building Services Manager

All current vacancies and studentships - Wed, 15/04/2026 - 01:00

The Department of Chemical Engineering and Biotechnology is seeking an experienced and proactive Building Services Manager to support the safe, efficient and reliable operation of its buildings and technical infrastructure.

Reporting to the Technical Operations Manager, you will take responsibility for the management of building fabric and engineering services across the Department, ensuring that teaching and research activities are supported by well-maintained, compliant and fit-for-purpose facilities. You will oversee planned and reactive maintenance, coordinate infrastructure and refurbishment projects, and act as the key departmental contact for works delivered by Estates Management and external contractors.

You will work closely with academic staff, technical teams and contractors to support building operations, maintenance activities and infrastructure developments. The role also includes responsibility for ensuring statutory compliance and safe systems of work, including permit-to-work processes, risk assessments and key areas such as water hygiene and fire safety.

You will have line management responsibility for the Building Services team, ensuring effective delivery of services, prioritisation of work and ongoing staff development. You will also act as a principal key holder, including participation in an on-call rota to respond to out-of-hours incidents.

The postholder must have degree/Level 6 vocational qualification in a relevant technical discipline or equivalent relevant practical experience together with a sound understanding of building services and facilities management in a complex environment. You will bring excellent organisational and problem-solving skills, technical knowledge across mechanical and/or electrical systems, and the ability to work collaboratively with a wide range of stakeholders.

The University offers a generous benefits package including 36 days of annual leave (inclusive of bank holidays), a competitive pension scheme and family-friendly policies.

We welcome applications from individuals who wish to be considered for flexible working arrangements.

We particularly welcome applications from women and candidates from a BME background for this vacancy as they are currently under-represented at this level in our School.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcome and can be directed to the Technical Operations Manager via hr@ceb.cam.ac.uk.

Please quote reference NQ49412 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Research Associate (Fixed Term)

All current vacancies and studentships - Wed, 15/04/2026 - 01:00

Applications are invited for a Research Assistant (pre-doctoral) or Research Associate (post-doctoral) to conduct world-leading research on Leveraging Ontological Knowledge with Argumentative Agentic AI to Accelerate Chemical Development under the direction of Prof Alexei Lapkin.

The project is a collaboration with Prof Francesca Toni from Imperial College London, Dr Antonio Rago from Kings College London and industrial collaborators within the AIChemy Hub (https://aichemy.ac.uk/). The successful candidate will focus on extending the ontological knowledge base of chemical process development and extending the simulation environment of process models, recently developed in the group of Prof. Lapkin based in Cambridge and in Singapore (in Cambridge Centre for Advanced Research and Education in Singapore).

The successful candidate will contribute to the development of reinforcement learning agents operating with the knowledge base and the simulation environment. The developed knowledge base will provide data for advanced argumentative agentic AI based on reinforcement learning being developed at Imperial College London and Kings College. The project will develop an approach of including ontological knowledge base and expert knowledge within a multi-agentic AI framework.

The post is based in the Department of Chemical Engineering and Biotechnology at the University of Cambridge. This is a leading department of Chemical Engineering among UK Universities. The successful applicant will join the Sustainable Reaction Engineering (SRE) research group, led by Prof Lapkin. The group is working on many aspects of transition towards sustainable chemistry, including digital transformation of R&D and manufacturing (lapkingroup.com).

The successful applicant will need to interact and collaborate with the other partners from Imperial College London, Kings College London and industry, as well as to engage with members of the AIchemy Hub, with expertise in AI and/or chemistry.

Duties and responsibilities

The position offers an exciting opportunity for conducting internationally leading and impactful research in chemical process development supported by AI. The postholder will be responsible for researching, shaping and delivering solutions based on chemical and process ontologies, the concept of knowledge graphs, simulation of models within Python environment, working in cloud computing environment and will be expected to submit publications to top-tier conferences and journals in Chemistry / Chemical Engineering and AI.

To apply for this position, you must have a strong background in chemical reaction engineering with a focus on first principles models and simulation using Python, and have experience in machine learning, for example, reinforcement learning, including a proven publication track-record, in at least two of the following areas, as well as ability and willingness to become familiar with the others: process modelling and simulation, machine learning, reinforcement learning, ontologies. You should also have:

  • A Master's degree (Research Assistant) or PhD degree (Research Associate) in chemical engineering or a related area.
  • Familiarity with advanced process modelling and simulation using first principles models.
  • Familiarity with machine learning, coding in Python.
  • Excellent communication skills and ability to work with others.
  • Ability to organise your own work and set priorities to meet deadlines.
  • Willingness to travel to conferences and meetings of the project and of the AIChemy Hubs.

Appointment at Research Associate level is dependent on having a PhD; those without a PhD will be appointed at Research Assistant level. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 10th of May 2026.

Please quote reference NQ49413 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Coordinator (Part Time, Fixed Term)

All current vacancies and studentships - Wed, 15/04/2026 - 01:00

The BioNano Engineering group, headed by Prof. Ljiljana Fruk (fruk-lab.com), is looking for an outstanding part-time (18.25 hours per week) Research Coordinator to work alongside team members and international partners and deliver activities related to recently awarded Nanoflash grant. Nanoflash aims to deliver new generation treatment for eye diseases such as macular degeneration and retinis pigmentosa in collaboration with partners from Italy, Switzerland, and Belgium. This position is funded by European Innovation Council.

The BioNano Engineering group (https://www.fruk-lab.com) exploits bioinspired strategies to develop new processes and materials to address ongoing health and sustainability challenges. In particular, the group is focused on designing bio-nano hybrid materials that can be used for various biomedical applications such as drug delivery systems for hard-to-treat cancers, and improved diagnostic tools.

The group has 20 members including 5 postdoctoral researchers, 11 PhD students and a number of MPhil students and visitors.

In addition to the activities managing Nanoflash grant, the role-holder will also provide administrative support to assist in accelerating research activities of the group:

  • Carry out research grant administration. Ensure that timesheets are kept up to date, keep records of each grant, update website, monitor expenditure on active grants, process expenses in line with grant guidelines, liaise with members of the University Research Office, Departmental staff, Finance and HR on research grants related matters.

  • Provide secretarial/clerical support. Diary management, identify suitable dates, book meeting rooms, organise catering, invite participants, organise travel, accommodation and parking, create agenda, take minutes, circulate papers and agenda, and follow up on any action plans.

  • Oversee financial administration activity. Monitor resources and expenditure against budgets, process invoices, orders and expense claims, follow financial regulations, track expenditure, liaise with the Accounts Team to ensure that Department accounts are up to date, ensure efficiency and effectiveness of processes and procedures, develop and review processes as required.

Fixed-term: The funds for this post are available until 31 December 2029 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 30th of April 2026.

Please quote reference NQ49428 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Grants Coordinator

Staff vacancies - Fri, 10/04/2026 - 01:00

The Department of Chemical Engineering & Biotechnology has a research grant income of £11.3 million per annum in 2024/2025. Key funders are UKRI, especially EPSRC, industry and ERC.

This post is dedicated to the coordination of new grant funding opportunities with over 30 academics within the department. The post is vital to the research objectives of the Department and will focus on pre-award co-ordination. We are seeking a proactive and highly organised Research Grants Co-ordinator who will provide comprehensive administrative support to academic staff applying for funding. This will involve coordinating the work on developing large grant bids, contributing to writing parts of the bids, liaising with pre-award and post-award grant management teams in the Department and in the Research Operations Office of the University. The role works closely with the Finance Co-ordinator in the preparation of bids as well as liaising with the Department’s Finance Manager.

The Research Grants Co-ordinator provides expert support and guidance to Principal Investigators (PIs) and Department based research staff, with an outcome of timely, accurate and risk-mitigated research grant applications. The role holder works in collaboration with PIs and project support staff to enable effective and efficient grant management of active research grants across the School across the full grants lifecycle. The role will use University systems such as Worktribe and CUFS. The ability to communicate with confidence to a wide range of people and an effective flexible team player is key. You will need to possess a high level of organisation and prioritisation skills with the ability to take initiative and balance a varied workload to meet deadline.

You will require some understanding about grant development: structure of grants, coordination of multiple partners, interactions with funding bodies and understanding of requirements and specifications of different funding calls, interactions with University's pre-award team of the Research Operations Office. The postholder will work with the Deputy Head of the Department (Research) in supporting the Research Committee, and has the primary aim of increasing grant income for the department.

You will be educated to degree level or an equivalent level of practical experience.

Experience of a similar role in research grants/finance along with managing budgets is essential. Competent use of Microsoft Office is also essential.

Applications will be rapidly reviewed after the closing date and interviews will be shortly after.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

We welcome applications from individuals who wish to be considered for flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Dr Tom Matthams, Business & Operations Manager at tjm16@cam.ac.uk. If you have questions on the application process please email Vito Candela, HR Administrator at hr@ceb.cam.ac.uk.

Please quote reference NQ49385 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Grants Coordinator

Assistant staff vacancies - Fri, 10/04/2026 - 01:00

The Department of Chemical Engineering & Biotechnology has a research grant income of £11.3 million per annum in 2024/2025. Key funders are UKRI, especially EPSRC, industry and ERC.

This post is dedicated to the coordination of new grant funding opportunities with over 30 academics within the department. The post is vital to the research objectives of the Department and will focus on pre-award co-ordination. We are seeking a proactive and highly organised Research Grants Co-ordinator who will provide comprehensive administrative support to academic staff applying for funding. This will involve coordinating the work on developing large grant bids, contributing to writing parts of the bids, liaising with pre-award and post-award grant management teams in the Department and in the Research Operations Office of the University. The role works closely with the Finance Co-ordinator in the preparation of bids as well as liaising with the Department’s Finance Manager.

The Research Grants Co-ordinator provides expert support and guidance to Principal Investigators (PIs) and Department based research staff, with an outcome of timely, accurate and risk-mitigated research grant applications. The role holder works in collaboration with PIs and project support staff to enable effective and efficient grant management of active research grants across the School across the full grants lifecycle. The role will use University systems such as Worktribe and CUFS. The ability to communicate with confidence to a wide range of people and an effective flexible team player is key. You will need to possess a high level of organisation and prioritisation skills with the ability to take initiative and balance a varied workload to meet deadline.

You will require some understanding about grant development: structure of grants, coordination of multiple partners, interactions with funding bodies and understanding of requirements and specifications of different funding calls, interactions with University's pre-award team of the Research Operations Office. The postholder will work with the Deputy Head of the Department (Research) in supporting the Research Committee, and has the primary aim of increasing grant income for the department.

You will be educated to degree level or an equivalent level of practical experience.

Experience of a similar role in research grants/finance along with managing budgets is essential. Competent use of Microsoft Office is also essential.

Applications will be rapidly reviewed after the closing date and interviews will be shortly after.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

We welcome applications from individuals who wish to be considered for flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Dr Tom Matthams, Business & Operations Manager at tjm16@cam.ac.uk. If you have questions on the application process please email Vito Candela, HR Administrator at hr@ceb.cam.ac.uk.

Please quote reference NQ49385 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Grants Coordinator

All current vacancies and studentships - Fri, 10/04/2026 - 01:00

The Department of Chemical Engineering & Biotechnology has a research grant income of £11.3 million per annum in 2024/2025. Key funders are UKRI, especially EPSRC, industry and ERC.

This post is dedicated to the coordination of new grant funding opportunities with over 30 academics within the department. The post is vital to the research objectives of the Department and will focus on pre-award co-ordination. We are seeking a proactive and highly organised Research Grants Co-ordinator who will provide comprehensive administrative support to academic staff applying for funding. This will involve coordinating the work on developing large grant bids, contributing to writing parts of the bids, liaising with pre-award and post-award grant management teams in the Department and in the Research Operations Office of the University. The role works closely with the Finance Co-ordinator in the preparation of bids as well as liaising with the Department’s Finance Manager.

The Research Grants Co-ordinator provides expert support and guidance to Principal Investigators (PIs) and Department based research staff, with an outcome of timely, accurate and risk-mitigated research grant applications. The role holder works in collaboration with PIs and project support staff to enable effective and efficient grant management of active research grants across the School across the full grants lifecycle. The role will use University systems such as Worktribe and CUFS. The ability to communicate with confidence to a wide range of people and an effective flexible team player is key. You will need to possess a high level of organisation and prioritisation skills with the ability to take initiative and balance a varied workload to meet deadline.

You will require some understanding about grant development: structure of grants, coordination of multiple partners, interactions with funding bodies and understanding of requirements and specifications of different funding calls, interactions with University's pre-award team of the Research Operations Office. The postholder will work with the Deputy Head of the Department (Research) in supporting the Research Committee, and has the primary aim of increasing grant income for the department.

You will be educated to degree level or an equivalent level of practical experience.

Experience of a similar role in research grants/finance along with managing budgets is essential. Competent use of Microsoft Office is also essential.

Applications will be rapidly reviewed after the closing date and interviews will be shortly after.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

We welcome applications from individuals who wish to be considered for flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Dr Tom Matthams, Business & Operations Manager at tjm16@cam.ac.uk. If you have questions on the application process please email Vito Candela, HR Administrator at hr@ceb.cam.ac.uk.

Please quote reference NQ49385 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Business Support Apprentice

Staff vacancies - Wed, 25/03/2026 - 00:00

The Department of Chemical Engineering & Biotechnology is recruiting for a Business Support Apprentice to be part of the wider professional services team. The role holder will undertake training to provide support across areas such as HR, Reception, Safety, Finance, Communications, Outreach, and Student Administration.

You would be expected to work to a high standard, with increasing initiative and manage your priorities in order to successfully meet deadlines. The role holder will be undertaking, or be anticipating undertaking, a Level 3 Diploma in Business Administration and Level 2 Functional Skills Maths and English via Cambridge Regional College. The role holder will gain practical administration experience and a nationally recognised qualification.

Coordinate HR processes

  • Carry out HR administrative processes including recruitment and new starter processes, using university HR systems.
  • Assist the Recruitment process by scheduling interviews, notifying successful and unsuccessful candidates and requesting candidate references.
  • Facilitate new starter processes by conducting HR inductions for new staff.

Support Departmental Teams

  • Support the Safety Team with duties including assisting with office assessments, being a fire warden, and record keeping.
  • Support the Reception Team, welcoming employees, students and visitors in a friendly way.
  • Assist the Accounts Team.
  • Provide backup for the Stores area; receive goods, review and approve supplier invoices, partake in stock take.

Provide General Administrative Support

  • Provide backup for the Stores area; receive goods, review and approve supplier invoices, partake in stock take.
  • Maintain accurate records, keeping staff and student files organised.
  • Be involved in supporting any events, outreach activities and communications within the department.

We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level in our University.

To apply, please click on the below link and submit your application via the Apprenticeships Website:

https://www.findapprenticeship.service.gov.uk/apprenticeship/VAC2000021391

Applications closing dates 19th April 2026.

Fixed-term: 18 months.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level at the University.

Informal enquiries are welcomed and should be directed to Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 19th of April 2026.

Please quote reference NQ49192 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Business Support Apprentice

Assistant staff vacancies - Wed, 25/03/2026 - 00:00

The Department of Chemical Engineering & Biotechnology is recruiting for a Business Support Apprentice to be part of the wider professional services team. The role holder will undertake training to provide support across areas such as HR, Reception, Safety, Finance, Communications, Outreach, and Student Administration.

You would be expected to work to a high standard, with increasing initiative and manage your priorities in order to successfully meet deadlines. The role holder will be undertaking, or be anticipating undertaking, a Level 3 Diploma in Business Administration and Level 2 Functional Skills Maths and English via Cambridge Regional College. The role holder will gain practical administration experience and a nationally recognised qualification.

Coordinate HR processes

  • Carry out HR administrative processes including recruitment and new starter processes, using university HR systems.
  • Assist the Recruitment process by scheduling interviews, notifying successful and unsuccessful candidates and requesting candidate references.
  • Facilitate new starter processes by conducting HR inductions for new staff.

Support Departmental Teams

  • Support the Safety Team with duties including assisting with office assessments, being a fire warden, and record keeping.
  • Support the Reception Team, welcoming employees, students and visitors in a friendly way.
  • Assist the Accounts Team.
  • Provide backup for the Stores area; receive goods, review and approve supplier invoices, partake in stock take.

Provide General Administrative Support

  • Provide backup for the Stores area; receive goods, review and approve supplier invoices, partake in stock take.
  • Maintain accurate records, keeping staff and student files organised.
  • Be involved in supporting any events, outreach activities and communications within the department.

We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level in our University.

To apply, please click on the below link and submit your application via the Apprenticeships Website:

https://www.findapprenticeship.service.gov.uk/apprenticeship/VAC2000021391

Applications closing dates 19th April 2026.

Fixed-term: 18 months.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level at the University.

Informal enquiries are welcomed and should be directed to Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 19th of April 2026.

Please quote reference NQ49192 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Business Support Apprentice

All current vacancies and studentships - Wed, 25/03/2026 - 00:00

The Department of Chemical Engineering & Biotechnology is recruiting for a Business Support Apprentice to be part of the wider professional services team. The role holder will undertake training to provide support across areas such as HR, Reception, Safety, Finance, Communications, Outreach, and Student Administration.

You would be expected to work to a high standard, with increasing initiative and manage your priorities in order to successfully meet deadlines. The role holder will be undertaking, or be anticipating undertaking, a Level 3 Diploma in Business Administration and Level 2 Functional Skills Maths and English via Cambridge Regional College. The role holder will gain practical administration experience and a nationally recognised qualification.

Coordinate HR processes

  • Carry out HR administrative processes including recruitment and new starter processes, using university HR systems.
  • Assist the Recruitment process by scheduling interviews, notifying successful and unsuccessful candidates and requesting candidate references.
  • Facilitate new starter processes by conducting HR inductions for new staff.

Support Departmental Teams

  • Support the Safety Team with duties including assisting with office assessments, being a fire warden, and record keeping.
  • Support the Reception Team, welcoming employees, students and visitors in a friendly way.
  • Assist the Accounts Team.
  • Provide backup for the Stores area; receive goods, review and approve supplier invoices, partake in stock take.

Provide General Administrative Support

  • Provide backup for the Stores area; receive goods, review and approve supplier invoices, partake in stock take.
  • Maintain accurate records, keeping staff and student files organised.
  • Be involved in supporting any events, outreach activities and communications within the department.

We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level in our University.

To apply, please click on the below link and submit your application via the Apprenticeships Website:

https://www.findapprenticeship.service.gov.uk/apprenticeship/VAC2000021391

Applications closing dates 19th April 2026.

Fixed-term: 18 months.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level at the University.

Informal enquiries are welcomed and should be directed to Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 19th of April 2026.

Please quote reference NQ49192 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Research Associate in Vapour Deposition of Multijunction Perovskite Solar Cells

Research vacancies - Thu, 19/03/2026 - 00:00

Applications are invited for a Post-Doctoral Research Associate (PDRA) to work on vapour deposition of high-performance halide perovskite multijunction (tandem and triple-junction) solar cells. The candidate would be working as part of the ERC Consolidator Grant project VAPOURISE working on new deposition tools dedicated to the project. This project seeks to develop epitaxial growth of halide perovskites to enable new devices for energy generation (solar cells), conversion (solar fuels) and use (quantum emission) utilising multimodal characterisation platforms and automated analysis pipelines. This work builds on recent work in our group developing epitaxial growth by vapour deposition (Science 2025) and multimodal understanding of materials (Nature 2020, 2022, Science 2021, Nature Energy 2025).

We are looking for a highly motivated and enthusiastic candidate with a PhD in Physics, Chemistry, Materials Science, Engineering, Chemical Engineering or a related area. A proven track record of scientific publication and presentation at international conferences is essential.

Experience in perovskite solar cell (and/or other optoelectronic device) fabrication and characterisation is essential. Experience with multijunction perovskite solar cells and/or vapour deposition of halide perovskites is highly desired. Experience working with coding, automation and algorithm development is desired. The ability to conduct self-directed work whilst working together with colleagues in a wider programme will be essential. The role holder will also manage the key experimental setups associated with their work and extend existing capabilities. The PDRA will be team-oriented and work closely with other students (including some daily supervision) and PDRAs and international collaborators.

The successful PDRA candidate for this post will join the Optoelectronic Materials and Device Spectroscopy group (https://www.strankslab.com/) in the Department of Chemical Engineering & Biotechnology, and will also be part of the Optoelectronics Group (http://www.oe.phy.cam.ac.uk/). We are an inclusive and diverse group driving a number of active outreach and widening participation activities. Collectively, the PDRA will have access to world-leading expertise and facilities in the field of hybrid and organic electronics.

The successful candidate would start anytime from 1st September 2026, with some flexibility.

Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant and promoted to Research Associate when the PhD is awarded.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Should you require any further details on the role, please email Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 18th of May 2026.

Please quote reference NQ49154 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Research Associate in Vapour Deposition of Multijunction Perovskite Solar Cells

All current vacancies and studentships - Thu, 19/03/2026 - 00:00

Applications are invited for a Post-Doctoral Research Associate (PDRA) to work on vapour deposition of high-performance halide perovskite multijunction (tandem and triple-junction) solar cells. The candidate would be working as part of the ERC Consolidator Grant project VAPOURISE working on new deposition tools dedicated to the project. This project seeks to develop epitaxial growth of halide perovskites to enable new devices for energy generation (solar cells), conversion (solar fuels) and use (quantum emission) utilising multimodal characterisation platforms and automated analysis pipelines. This work builds on recent work in our group developing epitaxial growth by vapour deposition (Science 2025) and multimodal understanding of materials (Nature 2020, 2022, Science 2021, Nature Energy 2025).

We are looking for a highly motivated and enthusiastic candidate with a PhD in Physics, Chemistry, Materials Science, Engineering, Chemical Engineering or a related area. A proven track record of scientific publication and presentation at international conferences is essential.

Experience in perovskite solar cell (and/or other optoelectronic device) fabrication and characterisation is essential. Experience with multijunction perovskite solar cells and/or vapour deposition of halide perovskites is highly desired. Experience working with coding, automation and algorithm development is desired. The ability to conduct self-directed work whilst working together with colleagues in a wider programme will be essential. The role holder will also manage the key experimental setups associated with their work and extend existing capabilities. The PDRA will be team-oriented and work closely with other students (including some daily supervision) and PDRAs and international collaborators.

The successful PDRA candidate for this post will join the Optoelectronic Materials and Device Spectroscopy group (https://www.strankslab.com/) in the Department of Chemical Engineering & Biotechnology, and will also be part of the Optoelectronics Group (http://www.oe.phy.cam.ac.uk/). We are an inclusive and diverse group driving a number of active outreach and widening participation activities. Collectively, the PDRA will have access to world-leading expertise and facilities in the field of hybrid and organic electronics.

The successful candidate would start anytime from 1st September 2026, with some flexibility.

Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant and promoted to Research Associate when the PhD is awarded.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Should you require any further details on the role, please email Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 18th of May 2026.

Please quote reference NQ49154 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Oxidative Ring-Opening of Dimethylfuran in Zeolitic Imidazolate Frameworks through Computational Design

Pubmed - Wed, 11/03/2026 - 10:00

J Phys Chem C Nanomater Interfaces. 2026 Feb 19;130(9):3245-3252. doi: 10.1021/acs.jpcc.5c06617. eCollection 2026 Mar 5.

ABSTRACT

Furans are versatile feedstocks for producing valuable chemicals and fuels, with 2,5-dimethylfuran (DMF) particularly standing out for its potential in oxidative ring-opening reactions, yielding enediones. The zeolitic imidazolate framework ZIF-8 has shown promise as a mediator to achieve high selectivity, although a precise mechanistic understanding of how this heterogeneous system works is unclear. Here, we employ a computational protocol, combining a configurational search with force fields (GFN-FF) with a refinement at the periodic density functional theory (DFT) level, to model the oxidation of DMF with H2O2 and explicit MeOH solvent in the absence and presence of ZIF-8. In line with experimental observations, our results reveal that ZIF-8 suppresses overoxidation of the enedione cf. to results for the blank reaction. We further substituted the methyl group of ZIF-8 with other groups and tested the resulting materials in the above-mentioned reaction. We observe that vinyl-substituted ZIF emerges as the most selective material, while ZIF-H (SALEM-2) offers poor selectivity when compared with the blank reaction. A featurization study, correlating energy barriers and structural features, reveals how pore accessibility and linker geometry influence the selectivity. Our findings seek to deepen the understanding of molecular interactions in ZIFs and guide the rational design of MOFs for biomass conversion.

PMID:41810146 | PMC:PMC12969367 | DOI:10.1021/acs.jpcc.5c06617

Marie Curie Research Fellow (Fixed Term)

Research vacancies - Mon, 09/03/2026 - 00:00

We are recruiting for an exceptional Doctoral (PhD) Candidate to join the new MSCA Doctoral Network FairCFD (https://www.imft.fr/faircfd/project-presentation/). The candidate will enrol for a PhD in Chemical Engineering at the University of Cambridge, under the supervision of Prof. Andy Sederman.

FairCFD offers a unique opportunity to engage in experimental research linked to computational fluid dynamics (CFD) and more broadly engaging with scientific computing. The postholder will benefit from a unique breadth of experiences including:

  • Contribute to technological innovation in health/food industries by developing advanced and efficient data measurement strategies.
  • Join a vibrant network of 15 doctoral candidates, across 9 European countries, with access to network events, high-level training to technical and transverse skills, and secondments in both academic and industrial environments.
  • Take part in a network-wide interdisciplinary effort to define and promote numerical sustainability in scientific research.

Flow MRI (magnetic resonance imaging of flowing fluids) is a non-invasive imaging technique that measures 3D and time resolved velocity fields in opaque fluids, making it uniquely valuable for studying flows under realistic operating conditions in a range of engineering and medical applications.

Recent advances in acquisition strategies and model based data assimilation improve the ability of Flow MRI to be used not just to visualise flow but to infer rheological behaviour directly from experimental data. This project will develop these capabilities by combining high information content Flow MRI datasets with physics based modelling and Bayesian inference to determine constitutive models for non-Newtonian and other complex fluids in situ. The project will require development of advanced experimental and data analysis skills and will work closely with the Doctoral candidate working in Cambridge on data assimilation (https://www.imft.fr/dc10-arterial-circulation/)

The objectives of the proposed study are to (i) design and run Flow MRI experiments on a range of non Newtonian fluids in steady and periodic flow (ii) develop and optimise MRI acquisition strategies to improve the efficiency of data collection and enhance spatial and temporal resolution (iii) increase the quantitative accuracy of Flow MRI data through improved reconstruction, and uncertainty estimation and (iv) assess the ability to accurately model these complex fluids by using adjoint accelerated Bayesian inference with the experimental Flow MRI data.

The implementation of new Flow-MRI acquisition and reconstruction strategies will enable measurement of flows at greater resolution and fidelity than has been possible previously. These new capabilities will be used to investigate applications that have not previously been possible including the healthcare sector (blood flow in hearts and arteries) and to assess rheology models in process fluids and foods.

The project involves secondments at the KTH (Stockholm, Sweden) and the University of Salerno (Salerno, Italy).

Applicants for the studentships must have a First Class (or a high 2:1) or equivalent degree in a relevant discipline such as chemical engineering, engineering or physics and must not have spent more than 12 months in the UK for the past 3 years.

Please see further information about the programme at https://www.imft.fr/faircfd/project-presentation/.

The successful candidate would be employed as a Research Assistant and they must apply for admission as a PhD student with the University and be able to meet our criteria for admission. This application must also be made by the closing date. For further information please visit: https://www.postgraduate.study.cam.ac.uk/courses/directory/egcepdcng

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Should you require any further details on the role please contact Prof. Andy Sederman at ajs40@cam.ac.uk. If you have questions on the application process, please email Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 26th of April 2026.

Please quote reference NQ49025 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Marie Curie Research Fellow (Fixed Term)

All current vacancies and studentships - Mon, 09/03/2026 - 00:00

We are recruiting for an exceptional Doctoral (PhD) Candidate to join the new MSCA Doctoral Network FairCFD (https://www.imft.fr/faircfd/project-presentation/). The candidate will enrol for a PhD in Chemical Engineering at the University of Cambridge, under the supervision of Prof. Andy Sederman.

FairCFD offers a unique opportunity to engage in experimental research linked to computational fluid dynamics (CFD) and more broadly engaging with scientific computing. The postholder will benefit from a unique breadth of experiences including:

  • Contribute to technological innovation in health/food industries by developing advanced and efficient data measurement strategies.
  • Join a vibrant network of 15 doctoral candidates, across 9 European countries, with access to network events, high-level training to technical and transverse skills, and secondments in both academic and industrial environments.
  • Take part in a network-wide interdisciplinary effort to define and promote numerical sustainability in scientific research.

Flow MRI (magnetic resonance imaging of flowing fluids) is a non-invasive imaging technique that measures 3D and time resolved velocity fields in opaque fluids, making it uniquely valuable for studying flows under realistic operating conditions in a range of engineering and medical applications.

Recent advances in acquisition strategies and model based data assimilation improve the ability of Flow MRI to be used not just to visualise flow but to infer rheological behaviour directly from experimental data. This project will develop these capabilities by combining high information content Flow MRI datasets with physics based modelling and Bayesian inference to determine constitutive models for non-Newtonian and other complex fluids in situ. The project will require development of advanced experimental and data analysis skills and will work closely with the Doctoral candidate working in Cambridge on data assimilation (https://www.imft.fr/dc10-arterial-circulation/)

The objectives of the proposed study are to (i) design and run Flow MRI experiments on a range of non Newtonian fluids in steady and periodic flow (ii) develop and optimise MRI acquisition strategies to improve the efficiency of data collection and enhance spatial and temporal resolution (iii) increase the quantitative accuracy of Flow MRI data through improved reconstruction, and uncertainty estimation and (iv) assess the ability to accurately model these complex fluids by using adjoint accelerated Bayesian inference with the experimental Flow MRI data.

The implementation of new Flow-MRI acquisition and reconstruction strategies will enable measurement of flows at greater resolution and fidelity than has been possible previously. These new capabilities will be used to investigate applications that have not previously been possible including the healthcare sector (blood flow in hearts and arteries) and to assess rheology models in process fluids and foods.

The project involves secondments at the KTH (Stockholm, Sweden) and the University of Salerno (Salerno, Italy).

Applicants for the studentships must have a First Class (or a high 2:1) or equivalent degree in a relevant discipline such as chemical engineering, engineering or physics and must not have spent more than 12 months in the UK for the past 3 years.

Please see further information about the programme at https://www.imft.fr/faircfd/project-presentation/.

The successful candidate would be employed as a Research Assistant and they must apply for admission as a PhD student with the University and be able to meet our criteria for admission. This application must also be made by the closing date. For further information please visit: https://www.postgraduate.study.cam.ac.uk/courses/directory/egcepdcng

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Should you require any further details on the role please contact Prof. Andy Sederman at ajs40@cam.ac.uk. If you have questions on the application process, please email Mr Vito Candela, HR Administrator, at hr@ceb.cam.ac.uk.

Applications closing date 26th of April 2026.

Please quote reference NQ49025 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Bioelectronic Technology for Nutritional Research-a Novel In Vitro Platform for a Better Understanding of Human Gut Barrier Absorption

Pubmed - Wed, 18/02/2026 - 11:00

Adv Biol (Weinh). 2026 Feb;10(2):e00409. doi: 10.1002/adbi.202500409.

ABSTRACT

The epithelial gut barrier and gut microbiota significantly contribute to human health by controlling molecule absorption, a regulated transport that dictates bioavailability. Effective public health strategies, like dietary reference values, require a complete understanding of nutrient absorption. However, the lack of internationally harmonized nutritional recommendations indicates that gut barrier mechanisms are not fully unraveled. The conventional in vitro model Caco-2/HT29-MTX cultured on cell culture inserts, established for drug development, is limited in representing complex human gut physiology. The new bioelectronic e-transmembrane platform leverages technological and biological advances to generate more meaningful in vitro predictions. The soft electroactive Poly (3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) scaffold enables direct cell-electrode coupling for more sensitive barrier impedance measurements, especially required for testing commonly low physiological nutrient concentrations. Promoted epithelial-fibroblast interactions result in modulated protein signal transduction and expression of genes regulating gut barrier integrity. Overall, the e-transmembrane gut barrier more closely mimicked physiological effects for humans as demonstrated using the dietary compound butyrate.

PMID:41705600 | DOI:10.1002/adbi.202500409