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Department of Chemical Engineering and Biotechnology

 
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Current jobs in the Department of Chemical Engineering and Biotechnology at the University of Cambridge.
Updated: 7 min 42 sec ago

Developing a biosensor toolbox for key signalling pathways

Fri, 23/04/2021 - 00:00

The EPSRC Centre for Doctoral Training in Sensor Technologies for a Healthy and Sustainable Future, in collaboration with AstraZeneca, is inviting applications for a fully funded 1+3 years MRes+PhD studentship, commencing in October 2021. The studentship will be hosted in Dr Gabriele Kaminski Schierle's group (https://www.ceb-mng.org/) in the Department of Chemical Engineering and Biotechnology. In this project you will develop a biosensor toolbox to investigate key signalling pathways. Signalling pathways mediate cell-cell interactions and coordinate cellular responses to external stimuli. Many common chronic diseases are caused by aberrant signalling and most drugs act directly or indirectly on specific signalling events to mediate their therapeutic effects. Examination of second messengers and immediate downstream protein-protein interactions have been challenging due to the lack of reliable and sensitive tools that enable time-resolved tracking of signalling events and crosstalk between signalling pathways.

Specific objectives of the project include implementing an automated fluorescence lifetime imaging microscopy (FLIM) workflow to study phenotype function relationships using cell based assays. You will use technology that combines advanced photonic sensor technologies, automation, and machine learning for the analysis of large data volumes. You will apply this technology to perform experiments with live cell models and learn how to construct and apply a range of advanced biosensors. Taking FLIM and spectral recordings at defined time points from samples subjected to different conditions will permit you, for example, to study dose response effects of candidate drugs supplied by AstraZeneca or to gain fundamental mechanistic insights of the cellular response to treatment. To complete this project, you will work both at the University of Cambridge and with colleagues at AstraZeneca.

The studentship is fully-funded for 4-years and the student will be enrolled in the Centre for Doctoral Training in Sensor Technologies for a Healthy and Sustainable Future (http://cdt.sensors.cam.ac.uk). The first year involves a highly interdisciplinary programme consisting of lectures, research and team projects covering a wide range of technologies sensing and imaging. Successful completion of the first year will lead to a Master of Research qualification (MRes) and optimal preparation for the PhD project in years 2-4. Additional training in potency assay development and assay qualification and further insights into industrial drug development activities will be provided by the AstraZeneca team involved in this project. We are seeking a highly motivated individual with a strong academic background, as demonstrated with a 1st class degree, or equivalent, in biophysics, bioengineering or a related relevant discipline. Demonstrable competency in computational data analysis, in particular using machine learning approaches, is an advantage.

Fixed-term: The funds for this post are available for 4 years.

For informal enquiries please contact Dr Gabriele Kaminski Schierle (gsk20@cam.ac.uk). To apply for this position please visit https://cdt.sensors.cam.ac.uk/admissions/how-apply

The deadline for applications is 21 May 2021. Note that only candidates who qualify for the Home fees rate are eligible for this studentship. You can check whether you qualify for the Home fee rate here: https://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status

Please quote reference NQ26426 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Jobs and studentships

Optofluidic Methods for In-process Virus Purification Analytics

Fri, 23/04/2021 - 00:00

The EPSRC Centre for Doctoral Training in Sensor Technologies for a Healthy and Sustainable Future, in collaboration with AstraZeneca, is inviting applications for a fully funded 1+3 years MRes+PhD studentship, commencing in October 2021. The studentship will be hosted in Dr Tijmen Euser's Optofluidics group within the Cambridge NanoPhotonics Centre (http://www.np.phy.cam.ac.uk) in the Department of Physics.

Virus and virus-like particle medicine development and manufacturing require improved analytical tools for reduced time to market of novel drugs and improved life cycle management of current viral products such as vaccines. The Euser lab in the Cambridge Nanophotonics Centre develops optofluidic microreactors, based on hollow-core photonic crystal fibres (HC-PCF) to monitor chemical reactions with in-situ absorption, fluorescence, and automated online Raman spectroscopy. In addition, the group has strong expertise in fibre-based optical trapping- and tracking experiments with micro and nanoparticles. Recent publications from the group can be found here: https://publons.com/researcher/2573692/tijmen-g-euser/

The aim of this PhD project is to investigate the suitability of HC-PCF based optical techniques, including fluorescence, Raman, and scattering, to analyse and monitor FluMist/Fluenz live attenuated influenza virus production. The overall goal is to obtain increased manufacturing process understanding through additional particle characterization of in process and drug substance samples.

The studentship is fully-funded for 4-years, and the student will be enrolled in the Centre for Doctoral Training in Sensor Technologies for a Healthy and Sustainable Future (http://cdt.sensors.cam.ac.uk). The first year involves a highly interdisciplinary programme consisting of lectures, research and team projects covering a wide range of technologies sensing and imaging. Successful completion of the first year will lead to a Master of Research qualification (MRes) and optimal preparation for the PhD project in years 2-4. We are seeking a highly motivated individual with a strong academic background, as demonstrated with a 1st class degree, or equivalent, in physics, biophysics, bioengineering, or a related relevant discipline.

The ideal candidate will have hands-on experience in microscopy, experience with biochemical sample preparation, and a good understanding of optical characterization techniques (fluorescence, Raman, dynamic light scattering). The candidate should have a strong motivation for interdisciplinary research and, ideally, have experience in building automated experimental rigs. These skills will be strengthened during the MRes year of the CDT programme. The candidate will work with the AstraZeneca team involved in this project to identify and prioritise analytical development in the Euser lab for the analysis of in-process material. The candidate will also work with the AstraZeneca team to gain understanding of all currently available in-process and drug substance analytical methods with a view to identifying where analysis by methods available in the Euser lab could provide complementary analytical data. The AstraZeneca team will provide guidance on assay development and qualification as required.

Fixed-term: The funds for this post are available for 4 years.

For informal enquiries please contact Dr Tijmen Euser (te287@cam.ac.uk). To apply for this position please visit https://cdt.sensors.cam.ac.uk/admissions/how-apply

The deadline for applications is 21 May 2021. Note that only candidates who qualify for the Home fees rate are eligible for this studentship. You can check whether you qualify for the Home fee rate here: https://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status

Please quote reference NQ26427 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Jobs and studentships

Accounts Assistant

Mon, 19/04/2021 - 00:00

The Department of Chemical Engineering and Biotechnology wishes to appoint an Accounts Assistant to help support our busy finance team.

The successful candidate will undertake the administration of accounts and maintain financial records within the Department in order to contribute to the management of Departmental finances. They will assist in the provision of a largely autonomous accounting and purchasing service, responsible for the processing of about 4500 invoices per annum of total value £2M. Grant income is £6M per annum. The postholder will have purchasing responsibility up to £5,000, and will undertake cash management, journal transfers, and various accounting reports.

The postholder will also provide cover in Stores during periods of leave of Stores personnel, assisting members of the Department in the ordering and collection of items.

Educated to A- Level standard or equivalent, the post holder will be expected to have (or be working towards) an appropriate AAT qualification and also have previous experience working in an Accounts environment. In addition the successful candidate would need to demonstrate knowledge of facts, principles, processes and general concepts related to Finance/Accounts Administration.

Excellent communication and organisational skills, and familiarity with Microsoft Office packages will also be expected along with experience of appropriate reporting tools.

Further information about the Department is available from the website: https://www.ceb.cam.ac.uk/.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For an informal discussion about the post, please contact For an informal discussion about the post, please contact Dr Tom Matthams - hr@ceb.cam.ac.uk

Please quote reference NQ26366 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Jobs and studentships

Research Assistant/Research Associate (Fixed Term) - Novel microcapsule designs and manufacturing processes

Thu, 15/04/2021 - 00:00

The Department of Chemical Engineering and Biotechnology wishes to appoint a Research Assistant/Research Associate to work on a project with Professor Alex Routh.

The project is a collaboration between the Universities of Birmingham, Cambridge and Leeds and has recently been granted funding from the EPSRC for a project entitled 'Novel microcapsule designs and manufacturing processes'.

As a result, we are offering 3 Post-doctoral research fellow positions, one at each institution, to drive innovation in the design and manufacturing of encapsulation systems. All 3 researchers will work in close collaboration with each other on developing fundamental science understanding of systems and processes that address current industrial needs in this area. The Cambridge based Research Assistant/Research Associate will develop methods of emulsification using fluid mechanical mixing. Inclusion of surface-active particles will enable Pickering emulsions and consequently microcapsules to be made.

Particulate products contribute £50 Billion per year to the UK economy. Enabling targeted functionality and enhanced processability expands the applicability of such products. Encapsulation is one route to the desired smart particulate materials and this project aims to develop both new energy-efficient ways of producing microcapsules on industrial scales, and new microcapsule designs with shells that are environmentally-friendly, possess controllable breakage stresses, enhanced active ingredient (AI) retention properties and improved deposition on target surfaces. The project will allow for drastically improved microcapsule efficiency and sustainability under an increasingly stringent regulatory environment, thus leading to both expanding the use of microcapsules across formulated products and as a result improving the efficacy of AIs such as pesticides, fragrance oils, pharmaceutical drugs.

We are looking for a candidate who has a PhD (or is close to being awarded a PhD) in Chemical Engineering, Physics, Chemistry or a related discipline.

More information about the Department and Prof Alex Routh's group are available below:

https://www.ceb.cam.ac.uk/research/groups/rg-colloidal-dispersions

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For an informal discussion about the post, please contact For an informal discussion about the post, please contact Prof Alex Routh - afr10@cam.ac.uk

Please quote reference NQ26414 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Jobs and studentships

Probabilistic Machine Learning for Mobile and Wearable Health Data and Systems

Wed, 14/04/2021 - 00:00

Probabilistic Machine Learning for Mobile and Wearable Health Data and Systems

The EPSRC Centre for Doctoral Training in Sensor Technologies for a Healthy and Sustainable Future, in collaboration with Arm, is inviting applications for a fully funded 1+3 years MRes + PhD studentship, commencing in October 2021. The studentship will be hosted by Professor Cecilia Mascolo's group (https://mobile-systems.cl.cam.ac.uk) in the Department of Computer Science and Technology.

This project will investigate the general area of probabilistic machine learning in the context of wearable data and systems. The area offers unique challenges related to estimation of uncertainty in the context of wellbeing and clinical applications as well as with devices which generally offer considerably constrained resources. During the first year of the programme, the student will identify specific objectives and write a project proposal under the guidance of Prof. Mascolo.

Mobile and wearable devices use is soaring, and their sensing capabilities are expanding. The data they produce can be very valuable in the investigation of user's wellbeing in general and more precisely of their health. Mascolo's team has investigated various aspects of this research area ranging from data specific challenges to the machine learning (automatic model adaptation, automatic labelling, missing data resilient approaches) or to the systems aspects of on device model computation. The group also researches at the level of innovative sensing modalities for specific applications.

The studentship is fully-funded for 4-years and will be hosted at the University of Cambridge in the Department of Computer Science and Technology. The student will be enrolled in the Centre for Doctoral Training in Sensor Technologies for a Healthy and Sustainable Future (http://cdt.sensors.cam.ac.uk). The first year involves a highly interdisciplinary programme consisting of lectures, research and team projects covering a wide range of technologies sensing and imaging. Successful completion of the first year will lead to a Master of Research qualification (MRes) and optimal preparation for the PhD project in years 2-4. We are seeking a highly motivated individual with a strong academic background, as demonstrated with a 1st class degree, or equivalent, in a Computer Science or Computer Engineering. The candidate will have demonstrable knowledge in machine learning and possibly experience with mobile and wearable or sensing data.

For informal enquiries please contact Prof Cecilia Mascolo (https://www.cl.cam.ac.uk/~cm542/). To apply for this position please visit http://cdt.sensors.cam.ac.uk/how-to-apply The deadline for applications is 15 May 2021. Note that only candidates who qualify for the Home fees rate are eligible for this studentship. You can check whether you qualify for the Home fee rate here: https://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status

Please quote reference NQ26306 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Jobs and studentships