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Department of Chemical Engineering and Biotechnology

Professor Clemens Kaminski

Research

We develop and apply advanced imaging techniques to follow biological processes in living systems with molecular scale resolution. We make use of so called superresolution methods that break the resolution limit imposed by diffraction, molecular biotechnology, and machine learning to study molecular mechanisms of disease. We collaborate widely with medics, biologists, physicists, and engineers to look at the essential processes of living things. We collaborate closely with the Molecular Neuroscience Group, also in this department.

Biography

Clemens Kaminski is Professor of Chemical Physics at the University of Cambridge, UK. He is Director of the EPSRC Centre for Doctoral Training in Sensor Technologies and Applications and Head of the Department of Chemical Engineering and Biotechnology. He obtained his PhD at the University of Oxford, UK, in 1995, held a Marie Curie post-doctoral fellowship and Associate-Professorship at the Lund Institute of Technology in Sweden before his appointment at the University of Cambridge in 2001. He has pioneered the development of advanced imaging techniques for the study of chemical dynamics in technical and biological systems. He is recipient of the Cyril Hinshelwoold prize, Felix Weinberg prize, Philip Leverhulme prize, and the Rosalind Franklin Medal and Prize. Today his group focuses solely on the development and application of of advanced microscopy techniques to unravel molecular mechanisms of disease. Kaminski is a Fellow of Optica, the Royal Society of Chemistry, and the Institute of Physics.

Publications

Key publications: 

Scheeder A, Brockhoff M, Ward EN, Kaminski Schierle GS, Mela I, and Kaminski CF. "Molecular Mechanisms of Cationic Fusogenic Liposome Interactions with Bacterial Envelopes" J. Am. Chem. Soc., 145:51 pp 28240–28250 (2023) 

Lu M, Christensen CN, Weber JM, Konno T, Läubli NF, Scherer KM, Avezov E, Lio P, Lapkin AA, Kaminski Schierle GS and Kaminski CF. "ERnet: a tool for the semantic segmentation and quantitative analysis of endoplasmic reticulum topology" Nature Methods 20, 569–579 (2023) 

Ward EN, Hecker L, Christensen CN, Lamb JR, Lu M, Mascheroni L, Chung CE, Wang A, Rowlands CJ, Kaminski Schierle GS, Kaminski CF. "Machine learning assisted interferometric structured illumination microscopy for dynamic biological imaging" Nature Commun. 13, 7836 (2022) 

Scherer KM, Mascheroni L, Carnell GW, Wunderlich LCS, Makarchuk S, Brockhoff M, Mela I, Fernandez-Villegas A, Barysevich M, Stewart H, Suau Sans M, George CL, Lamb JR, Kaminski-Schierle GS, Heeney JL, Kaminski CF. "SARS-CoV-2 nucleocapsid protein adheres to replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress" Science Advances. 8:1 (2022) 

Lu M, van Tartwijk FW, Lin JQ, Nijenhuis W, Parutto  P, Fantham M, Christensen CN, Avezov E, Holt CE, Tunnacliffe A, Holcman D, Kapitein L, Kaminski-Schierle G, Kaminski CF. "The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes" Science Advances 6:51 (2020) 

Other publications: 

Google Scholar profile: https://tinyurl.com/CFK-scholar 

  1. Lu, M., Christensen, C., Weber, J., Konno, T., Laubli, N., Scherer, K., Avezov, E., Lio, P., Lapkin, A., Kaminski Schierle, G., & others. (2023). ERnet: a tool for the semantic segmentation and quantitative analysis of endoplasmic reticulum topology. Nature Methods, (2023), in press, available online. 

  1. Laine, R.F., Poudel, C., Kaminski, C.F., “A method for the fast and photon‐efficient analysis of time‐domain fluorescence lifetime image data over large dynamic ranges”, J. Micros., (2022) 287(3), 138-147. 

  1. Parutto, P., Heck, J., Lu, M., Kaminski C.F., Avezov, E., Heine, M., Holcman, D., “High-throughput super-resolution single-particle trajectory analysis reconstructs organelle dynamics and membrane reorganization”, Cell reports methods 2 (8), 100277 

  1. Nahas, K.L., Connor, V., Scherer, K.M., Kaminski, C.F., Harkiolaki, M., Crump, C.M.,  Graham, S.C., "Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection", PLoS Pathogens (2022) 18(8). 

  1. van Tartwijk F, Kaminski, C.F., "Protein condensation, cellular organization, and spatiotemporal regulation of cytoplasmic properties", Adv. Biology (2022), 2101328. 

  1. Li, W, Kaminski Schierle, GS, Lei, B, Liu, Y,  Kaminski, CF, "Fluorescent Nanoparticles for Super-Resolution Imaging", Chemical Reviews (2022), 122 (15), 12495-12543 

  1. Bali, K, Mohamed, Z, Scheeder, A, Pappa, A-M, Daniel, S, Kaminski, CF, Owens, R.M., Mela, I., "Nanoscale Features of Tunable Bacterial Outer Membrane Models Revealed by Correlative Microscopy", Langmuir (2022), 6(24) 

  1. Chung, C.W., Stephens, A.D., Ward, E., Feng, Y., Davis, M.J., Kaminski, C.F., Kaminski Schierle, G.S., "Label-Free Characterization of Amyloids and Alpha-Synuclein Polymorphs by Exploiting Their Intrinsic Fluorescence Property", Anal. Chem. (2022), 94(13), 5367-5474 

  1. Chambers JE, Zubkov N, Kubánková M, Nixon-Abell J, Mela I, Abreu S, Schwiening M, Lavarda G, López-Duarte I, Dickens JA, Kaminski CF, etc al. “Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state”. Science Advances (2022), 8(14), eabm2094. 

  1. Vanderpoorten, O., Babar, A. N., Krainer, G., Jacquat, R. P. B., Challa, P. K., Peter, Q., Toprakcioglu, Z., Xu, C. K., Keyser, U. F., & Baumberg, J. J..”Nanofluidic Traps by Two-Photon Fabrication for Extended Detection of Single Macromolecules and Colloids in Solution”. ACS Applied Nano Materials (2022), 5(2), 1995–2005. 

  1. Scherer, K. M., Mascheroni, L., Carnell, G. W., Wunderlich, L. C. S., Makarchuk, S., Brockhoff, M., Mela, I., Fernandez-Villegas, A., Barysevich, M., & Stewart, H.”SARS-CoV-2 nucleocapsid protein adheres to replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress”. Science Advances (2022), 8(1), eabl4895. 

  1. Crocker, L. B., Lee, J. H., Mital, S., Mills, G. C., Schack, S., Bistrović-Popov, A., Franck, C. O., Mela, I., Kaminski, C. F., & Christie, G. Tuning riboflavin derivatives for photodynamic inactivation of pathogens. Scientific Reports (2022), 12(1), 1–11. 

  1. Knowles, T. P. J., Challa, P. K., Saar, K. L., Peter, Q. A., Kaminski, C., & Vanderpoorten, O.. Particle characterization using optical microscopy. US Patent App. (2022) 17/296,208. 

  1. Darvishi, S., Tavakoli, S., Kharaziha, M., Girault, H. H., Kaminski, C. F., & Mela, I., “Advances in the Sensing and Treatment of Wound Biofilms”. Angewandte Chemie International Edition (2022), 61(13), e202112218. 

  1. Liu, X., Tang, M., Meng, C., Pang, C., Kuang, C., Chen, W., Kaminski, C. F., Yang, Q., & Liu, X. (2021). “Chip-compatible wide-field 3D nanoscopy through tunable spatial frequency shift effect”. Science China Physics, Mechanics & Astronomy (2021), 64(9), 1–10. 

  1. Tang, M., Han, Y., Ye, D., Zhang, Q., Pang, C., Liu, X., Shen, W., Ma, Y., Kaminski, C. F., & Liu, X.” High‐Refractive‐Index Chip with Periodically Fine‐Tuning Gratings for Tunable Virtual‐Wavevector Spatial Frequency Shift Universal Super‐Resolution Imaging”. Advanced Science, 9(9), 2103835. 

  1. Lindenburg LH, Pantelejevs T, Gielen F, Zuazua-Villar P, Butz M, Rees E, Kaminski CF,  Downs JA, Hyvönen M, Hollfelder F, “Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats”, PNAS (2021) 118 (46) e2017708118 

  1. Meng B, Vallejo Ramirez PP, Scherer KM, Bruggeman E, Kenyon JC, Kaminski CF, Lever AM, “EAP45 association with budding HIV-1: Kinetics and domain requirements.” Traffic (2021); 22( 12): 439- 453 

  1. Hardenberg MC, Sinnige T, Casford S, Dada ST; Poudel C; Robinson EA; Fuxreiter M; Kaminski CF; Kaminski Schierle GS; Nollen EAA, “Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies” J. Mol. Cell. Biol. (2021), 13 (4), 282-294   

  1. Perni M, van der Goot A, Limbocker R, van Ham TJ, Aprile FA, Xu CK, Flagmeier P, Thijssen K, Sormanni P, Fusco G, "Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease" Front. cell dev. biol. (2021) 9, 492ff 

  1. Xiaowei L, Tang M, Meng C,Pang C, Kuang C, Chen W, Kaminski CF, Yang Q, Liu X,"Chip-compatible wide-field 3D nanoscopy through tunable spatial frequency shift effect", Science China Phys. Mech. Astr. (2021), 64 (9) 

  1. Lu M, Mishra A, Boschetti C, Lin J, Liu Y, Huang H, Kaminski CF, Huang Z, Tunnacliffe A, Kaminski Schierle GS, "Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat", Oxid. Med. Cell. Long., (2021)     

  1. Christensen CB, Ward EN, Lu M, Lio P, Kaminski CF, “ML-SIM: universal reconstruction of structured illumination microscopy images using transfer learning”, Biomedical Optics Express (2021) 12 (5), 2720-2733 

  1. Wunderlich LCS, Ströhl F, Ströhl S, Vanderpoorten O, L Mascheroni, ..., Kaminski CF, "Superresolving the kidney—a practical comparison of fluorescence nanoscopy of the glomerular filtration barrier", Anal. Bioanal. Chem. (2021) 413 (4), 1203-1214. 

  1. Scherer KM, Manton JD, Soh TK, Mascheroni L, Connor V, Crump CM, Kaminski CF. "A fluorescent reporter system enables spatiotemporal analysis of host cell modification during herpes simplex virus-1 replication." J. Biol. Chem. (2021) 30:jbc.RA120.016571 

  1. Robbins M, Siddiqui O, Fuchsberger T, Goodfellow G, Paulsen O, Kaminski CF, Euser T, Kaminski-Schierle G. "OptoGenie: an open source device for the optogenetic stimulation of cells" J. Open Hardware, (2021), 5(1). 

  1. Hecker L, Wang W, Mela I, Fathi S, Poudel C, Soavi G, Huang YYS, Kaminski CF. "Guided Assembly and Patterning of Intrinsically Fluorescent Amyloid Fibers with Long-Range Order" Nano Lett. (2021), 21(2) 938–945. 

  1. Ben-Sasson AJ, Watson JL, Sheffler W, Johnson MC, Bittleston A, Somasundaram L, Decarreau J,  Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, De Yoreo JJ, Kollman JM, Ruohola-Baker H, Derivery E, Baker D "Design of biologically active binary protein 2D materials". Nature (2021) 589, 468–473.  

  1. Ströhl F, Lin JQ, van Tartwijk FW, Wong HHW, Holt CE, Kaminski CF "A Protocol for Single-Molecule Translation Imaging in Xenopus Retinal Ganglion Cells." In N. Yamamoto & Y. Okada (Eds.), Single Molecule Microscopy in Neurobiology (pp. 295-308). New York, NY: Springer US. (2020) 

  1. Opstad IS, Ströhl F, Fantham M, Hockings C, Vanderpoorten O, van Tartwijk FW, Lin JQ, Tinguely JC, Dullo FT, Kaminski-Schierle GS, Ahluwalia BS, Kaminski CF. "A waveguide imaging platform for live-cell TIRF imaging of neurons over large fields of view" J Biophot. (2020), 13(6):e201960222. 

  1. Chakraborty T, Chen B, Daetwyler S, Chang BJ, Vanderpoorten O, Sapoznik E, Kaminski CF, Knowles TPJ, Dean KM, Fiolka R. "Converting lateral scanning into axial focusing to speed up three-dimensional microscopy." (2020) Light Sci. Appl. 9, 165. 

  1. Lu M, van Tartwijk FW, Lin JQ, Nijenhuis W, Parutto  P, Fantham M, Christensen CN, Avezov E, Holt CE, Tunnacliffe A, Holcman D, Kapitein L, Kaminski-Schierle G, Kaminski CF. "The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes" Science Advances (2020) 6:51 

  1. Mela I, Kaminski CF. "Nano-vehicles give new lease fo lide to existing antimicrobials".  Emerg. Top. Life Sci. (2020) 4(6):555-566. 

  1. Wen Z, Wang L, Zhang X, Ma Y, Liu X, Kaminski CF, Yang Q, “Fast volumetric fluorescence imaging with multimode fibers”, Optics Lett. (2020) 45 (17), 4931-4934 

  1. Mascheroni L, Scherer KM, Manton JD, Ward E, Dibben O, Kaminski CF, Combining sample expansion and light sheet microscopy for the volumetric imaging of virus-infected cells with super-resolution, Biomed.  Opt. Exp. 11 (9), 5032-5044 

  1. Lautenschläger J, Wagner-Valladolid S, Stephens AD, ..., Kaminski CF, Kaminski Schierle GS, “Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β 1-42 pathologies”, JBC (2020), jbc. RA119. 011650 

  1. Dolan SK, Kohlstedt M, Trigg S, Ramirez PV, Kaminski CF, Wittmann C, ..., Contextual flexibility in Pseudomonas aeruginosa central carbon metabolism during growth in single carbon sources”, Mbio (2020), 11 (2) 

  1. Mela I, Vallejo-Ramirez PP, Makarchuk S, Christie G, Bailey D, Henderson R, Sugiyama H, Endo M, Kaminski CF, “ DNA nanostructures as a tool for targeted antimicrobial delivery“ Angew. Chem. Int. (2020), 10.1002/ange.202002740 

  1. Manton JD, Ströhl F, Fiolka R, Kaminski CF, Rees EJ, “Concepts for structured illumination microscopy with extended axial resolution through mirrored illumination”, Biomed. Opt. Exp. (2020) 11, 2098-2108 

  1. Ghézali G; Vasile F; Curry N; Fantham M; Cheung G; Ezan P; Cohen-Salmon M; Kaminski CF; Rouach N, "Neuronal activity drives astroglial Connexin 30 in perisynaptic processes and shapes its functions” Cerebral Cortex (2020) 30, 753-766 

  1. Poudel C; Mela I; Kaminski CF "High-throughput, multi-parametric, and correlative fluorescence lifetime imaging" MAF (2020) 8, 024005 

  1. Perret S; Poudel C; Ghosh AN; Fanjoux G; Provino L; Taunay T; Monteville A; Landais D; Kaminski CF; Dudley JM "Silica-based photonic crystal fiber for the generation of broad band UV radiation” OSA Continuum (2020) 3, 31-42 

  1. Lu M; Kaminski CF; Kaminski Schierle GS "Advanced fluorescence imaging of in situ protein aggregation” Phys. Biol. (2020) 17, 021001 

  1. Haddad S; Abanades Lazaro I; Fantham M; Mishra A; Silvestre-Albero J; Osterrieth JWM; Kaminski Schierle GS; Kaminski CF; Forgan R; Fairen-Jimenez D "Design of a functionalized metal-organic framework system for enhanced targeted delivery to mitochondria” JACS (2020) 142, 6661-6674 

  1. Dolan SK, Kohlstedt M, Trigg S, Vallejo Ramirez P, Kaminski CF, Wittmann C, Welch M, “Contextual flexibility in Pseudomonas aeruginosa central carbon metabolism during growth in single carbon sources” Mbio (2020) 11, 2 

  1. Vallejo Ramirez P.P., Zammit J., Vanderpoorten O. …, Kaminski CF, "OptiJ: Open-source optical projection tomography of large organ samples."  Sci. Rep. (2019) 9, 15693  

  1. Vanderpoorten O, Peter Q, Challa PK, Keyser UF, Baumberg J, Kaminski CF & Knowles TPJ, "Scalable integration of nano-, and microfluidics with hybrid two-photon lithography", Microsystems & Nanoengineering (2019) 5(1):40 DOI  

  1. Shigeoka T; Koppers M; Wong HH-W; Lin JQ; et al "On-site ribosome remodeling by locally synthesized ribosomal proteins in axons”, Cell Reports (2019) 29, 3605-3619.  

  1. Koppers M; Cagnetta R; Shigeoka T; et al, "Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons” eLife (2019) 8, e48718 

  1. Ströhl F, Opstad IS, Tinguely JC, Dullo FT, Mela I, Osterrieth JWM, Ahluwalia B &, Kaminski CF, "Super-condenser enables labelfree nanoscopy", Opt. Express (2019)  27:25280-25292 

  1. Pang C, Li J, Tang M, Wang J, Mela I, Ströhl F, Hecker L, Shen W, Liu Q, Liu X, Wang Y, Zhang H, Xu M, Zhang X, Liu X, Yang Q & Kaminski CF. "On-Chip Super-Resolution Imaging with Fluorescent Polymer Films.", Adv. Funct. Mater. (2019) 29, 1900126 

  1. Ströhl F & Kaminski CF. "A concept for single-shot volumetric fluorescence imaging via orthogonally polarized excitation lattices.” Sci. Rep. (2019)  9(1):6425. 

  1. Huang C, Wagner-Valladolid S, Stephens AD, et al. "Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in C. elegans."  eLife (2019) , 8:e43059 

  1. Laine R, Sinnige T, Ma KY, Haack AJ, Poudel C, Gaida P, Curry N, Perni M, Nollen EAA, Dobson CM, Vendruscolo M, Kaminski Schierle GS, Kaminski CF "Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of αSynuclein and Polyglutamine in Aging Caenorhabditis elegans.", ACS Chem. Biol. (2019), 14(7):1628-1636. 

  1. Lu M, Williamson N, Mishra A, Michel CH, Kaminski Schierle GS, Tunnacliffe A & Kaminski CF "Structural progression of amyloid-β arctic mutant aggregation in cells revealed by multiparametric imaging" Journal of Biological Chemistry (2019), 294:1478-1487 

  1. Lu M, Benetta L, Young LJ, Smith EJ, Bates GP, Zaccone A, Kaminski Schierle GS, Tunnacliffe A & Kaminski CF "Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly." Journal of Biological Chemistry (2019), 249:257-268. 

  1. Poudel C & Kaminski CF. "Supercontinuum radiation in fluorescence microscopy and biomedical imaging applications." Journal of the Optical Society of America B (2019), 36:2. 

  1. Teplensky MH, Fantham M, Poudel C, Hockings C, Lu M, Guna A, et al. “A Highly Porous Metal-Organic Framework System to Deliver Payloads for Gene Knockdown.” Chem. (2019),5(11):2926–41.  

  1. Li W, Wu S, Xu X, Zhuang J, Zhang H, Zhang X, et al. Carbon dot-silica nanoparticle composites for ultralong lifetime phosphorescence imaging in tissue and cells at room temperature. Chem Mater. (2019), 31, 23, 9887-9894 

  1. Laine RF, Goodfellow G , Young LJ, Travers J, Carroll D, Dibben O, Bright H &  Kaminski CF. "Structured illumination microscopy combined with machine learning enables the high throughput analysis and classification of virus structure." eLife (2018), eLife 2018;7:e40183. 

  1. S Qamar, GZ Wang, SJ Randle, et al. "FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions."  Cell. (2018), 173(3):720–734.   

  1. Holcman D, Parutto P, Chambers JE, et al. "Single particle trajectories reveal active endoplasmic reticulum luminal flow."  Nat. Cell Biol. (2018), 20(10):1118.   

  1. Lu M, Williamson N, Mishra A, et al. "Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multi-parametric imaging." J. Biol. Chem. (2018), jbc-RA118RA118.004511.   

  1. Lu M, Banetta L, Young LJ, et al. "Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly." J. Biol. Chem. (2018), jbc-RA118.003500   

  1. Boott CE, Leitao EM, Hayward DW, et al. "Probing the Growth Kinetics for the Formation of Uniform 1D Block Copolymer Nanoparticles by Living Crystallization-Driven Self-Assembly." ACS Nano. (2018), 12(9):8920–8933.   

  1. Rowlands CJ, Ströhl F, Ramirez PPV, Scherer KM & Kaminski CF. "Flat-Field Super-Resolution Localization Microscopy with a Low-Cost Refractive Beam-Shaping Element."  Sci. Rep (2018), 8(1):5630.   

  1. Moghadam PZ, Islamoglu T, Goswami S, et al. "Computer-aided discovery of a metal-organic framework with superior oxygen uptake." Nat. Comms. (2018), 9(1).   

  1. Stephens AD, Nespovitaya N, Zacharopoulou M, et al. "Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing." Anal. Chem. (2018), 90(11):6975–6983.   

  1. Arnon ZA, Pinotsi D, Schmidt M, et al. "Opal-like Multicolor Appearance of Self-Assembled Photonic Array." ACS Appl. Mater. Interfaces. (2018), 10(24):20783–20789.  

  1. Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, Zago W, Fraser P, Tandon A, St George-Hyslop P, Rees E, Phillips JJ, De Simone A, Kaminski CF & Kaminski Schierle GS, "C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction", Nat. Comms. (2018), 9(7):712   

  1. CT Russell, EJ Rees, CF Kaminski, Homographically generated light sheets for the microscopy of large specimens Optics letters (2018) 43 (4), 663-666  

  1. U. Shimanovich, D. Pinotsi, K. Shimanovich, N. Yu, S. Bolisetty, J. Adamcik, R. Mezzenga, J. Charmet, F. Vollrath, E. Gazit, C. M. Dobson, G. Kaminski-Schierle, C. Holland, C. F. Kaminski, T. P. Knowles, "Biophotonics of Native Silk Fibrils", Macromol. Biosci (2018), 1700295.  

  1. Ströhl F, Wong HHW, Holt CE, Kaminski CF, "Total internal reflection fluorescence anisotropy imaging microscopy: setup, calibration, and data processing for protein polymerization measurements in living cells", Methods Appl. Fluoresc. 6 (2018), 014004. 2017 

  1. L. J. Young, G. Kaminski-Schierle, C. F. Kaminski, "Imaging Aβ(1–42) fibril elongation reveals strongly polarised growth and growth incompetent states", Phys. Chem. Chem. Phys., 19, (2017),27987-27996. 

  1. Guttenplan APM, Young LJ, Matak-Vinkovic D, Kaminski CF, Knowles TPJ Itzhaki LS, "Nanoscale click-reactive scaffolds from peptide self-assembly", J. Nanobiotechnol., (2017), 15:70.  

  1. Wong HH-W, Lin J Q, Ströhl F, Roque CG, Cioni J-M, Cagnetta R, Turner-Bridger B, Laine R F, Harris WH, Kaminski CF, Holt CE (2017). "RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo" Neuron 95 (4) 852-868.  

  1. Ströhl F and Kaminski CF (2017). "Speed limits of structured illumination microscopy". Opt. Lett. (2017) 42(13), 2511-2514.  

  1. Teplensky MH, Fantham M, Li P, Wang TC, Mehta JP, Young LJ, Moghadam PZ, Hupp JT, Farha OK, Kaminski CF, Fairen-Jimenez D "Temperature treatment of highly porous zirconium-containing metal–organic frameworks extends drug delivery release", J. Am. Chem. Soc. (2017), 139(22), 7522-7532.  

  1. Ströhl F, Lin JQ, Laine RF, Wong HH, Urbančič V, Cagnetta R, Holt CE, Kaminski CF, "Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons", Sci. Rep. (2017), 7, 709.  

  1. Curry N, Ghézali G, Kaminski Schierle G, Rouach N, Kaminski CF, "Correlative STED and atomic force microscopy on live astrocytes reveals plasticity of cytoskeletal structure and membrane physical properties during polarized migration", Front. Cell. Neurosci. (2017), 11:104.  

  1. Melo EP, Lopes C, Gollwitzer P, Lortz S, Lenzen S, Mehmeti I, Kaminski CF, Ron D, Avezov E, "TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2", BMC Biol. (2017), 15(24).  

  1. Gaspar R, Meisl G, Buell AB, Young L, Kaminski CF, Knowles TPJ, Sparr E, Linse S, "Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification", Q. Rev. Biophys (2017), 50, e6.  

  1. Lautenschläger J, Kaminski CF, Kaminski Schierle GS, "α-Synuclein – Regulator of Exocytosis, Endocytosis, or Both?", Trends in Cell Biology (2017), 27(7), 468-9.  

  1. Nugent E, Kaminski CF, Kaminski Schierle GS, "Super-resolution imaging of alpha-synuclein polymorphisms and their potential role in neurodegeneration", Integr. Biol. (2017), 9, 206-210.   

  1. Gielen F, Butz M, Rees EJ, Erdelyi M, Moschetti T, Hyvönen M, Edel JB, Kaminski CF, Hollfelder F, "Quantitative affinity determination by fluorescence anisotropy measurements of individual nanoliter droplets", Anal. Chem. (2017), 89(2), 1092-1101.  

  1. Fantham M, Kaminski CF, "A new online tool for visualization of volumetric data", Nature Photonics (2017), 11 (2), 69 

  1. Gielen F, Butz M, Rees EJ, Erdelyi M, Moschetti T, Hyvönen M, Edel JB, Kaminski CF, Hollfelder F, "Quantitative affinity determination by fluorescence anisotropy measurements of individual nanoliter droplets", Anal. Chem. (2017) 89 (2), 1092-1101 

  1. Cai W, Kaminski CF, "Tomographic absorption spectroscopy for the study of gas dynamics and reactive flows", PECS. (2017), 59, 1-31.  

  1. Blacker TS, Chen WY, Avezov E, Marsh RJ, Duchen MR, Kaminski CF, Bain AJ, "Investigating state restriction in fluorescent protein FRET using time-resolved fluorescence and anisotropy", J. Phys. Chem. C (2016) 121 (3), 1507-1514 

  1. Nespovitaya N, Mahou P, Laine RF, Kaminski Schierle GS, Kaminski CF, "Heparin acts as a structural component of β-endorphin amyloid fibrils rather than a simple aggregation promoter", Chem. Commun. (2016).  

  1. Chen WY, Young LJ, Lu M, Zaccone A, Ströhl F, Yu N, Kaminski Schierle GS,  Kaminski CF, "Fluorescence self-quenching from reporter dyes informs on the structural properties of amyloid clusters formed in vitro and in cells", Nano Lett. (2016).  

  1. Gallardo R, Ramakers M, De Smet F, Claes F, Khodaparast L, Khodaparast L, Couceiro JR, Langenberg T, Siemons M, Nyström S, Young LJ, Laine RF, Young L, Radaelli E, Benilova I, Kumar M, Staes A, Desager M, Beerens M, Vandervoort P, Luttun A, Gevaert K, Bormans G, Dewerchin M, Van Eldere J, Carmeliet P, Vande Velde G, Verfaillie C, Kaminski CF, De Strooper B, Hammarström P, Nilsson KPR, Serpell L, Schymkowitz J, Rousseau F, "De novo design of a biologically active amyloid", Science. (2016), 354, aah4949.  

  1. Fusco G, Pape T, Stephens AD, Mahou P, Costa A, Kaminski CF, Kaminski Schierle GS, Vendruscolo M, Veglia G, Dobson CM, De Simone A "Structural basis of synaptic vesicle assembly promoted by α-synuclein", Nature Communications. (2016), 7: 12563.  

  1. Laine RF, Kaminski Schierle GS, van de Linde S, Kaminski CF "From single-molecule spectroscopy to super-resolution imaging of the neuron: a review", Methods Appl. Fluoresc. (2016), 4: 022004.  

  1. Kaminski CF, Kaminski Schierle GS "Probing amyloid protein aggregation with optical superresolution methods: from the test tube to models of disease", Neurophotonics (2016), 3(4), 041807.  

  1. Ströhl F, Kaminski CF "Frontiers in structured illumination microscopy", Optica (2016), 3(6), 667-677.  

  1. Manton JD, Hughes JAE, Bonner O, Amjad OA, Mair P, Miele I, Wang T, Levdik V, Hall RD, Baekelandt G, Vasconcellos FC, Hadeler O, Hutter T, Kaminski CF "Development of an open technology sensor suite for assisted living— a student-led research project" J. Roy. Soc. Int. Foc. (2016) 6: 20160018.  

  1. Kaminski CF, da Cruz Vasconcellos F, Hadeler O "Sensors in technology and nature", J. Roy. Soc. Int. Foc. (2016), 6: 20160034. 

  1. Pinotsi D, Michel CH, Buell AK, Laine RF, Mahou P, Dobson CM, Kaminski CF, Kaminski Schierle GS, "Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons" PNAS (2016)  

  1. Pinotsi D, Grisanti L, Mahou P, Gebauer R, Kaminski C, Hassanali A, Kaminski Schierle G,"Proton transfer and structure-specific fluorescence in hydrogen bond-rich protein structures", JACS, (2016)  

  1. Albecka A, Laine RF, Janssen AFJ, Kaminski CF, Crump CM, "HSV-1 glycoproteins are delivered to virus assembly sites through dynamin-dependent endocytosis", Traffic (2016), 17: 21-39 

  1. Murakami T, Qamar S, et al, Kaminski CF,  George-Hyslop P.St., "ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function", Neuron (2015)  

  1. Manetsberger J, Manton JD, Erdelyi MJ, Lin H, Rees HD, Christie G and Rees E, "Ellipsoid localisation microscopy infers the size and order of protein layers in Bacillus spore coats", Biophys. J. (2015).   

  1. Manners I, Boott CE, Laine RF,  Mahou P,  Finnegan JR,  Leitao EM,  Webb SED,  Kaminski CF, "In situ visualization of block copolymer self-assembly in organic media by super-resolution fluorescence microscopy", Chem. Eur. J. (2015), 21:18539–18542.     

  1. Noble D, Kaminski CF., "Introduction for bioinspiration", Interface Focus (2015), 5, 4,  0052.  

  1. Pinotsi D, Kaminski Schierle GS, Kaminski CF., "Optical super-resolution imaging of β-amyloid aggregation in vitro and in vivo: method and techniques" Methods Mol Biol. (2016),1303:125-41.  

  1. Knight A, Kaminski CF and Sauer M, "Super-resolution fluorescent methods: where next for super-resolution?", Methods Appl. Fluoresc. (2015), 3, 030201.  

  1. M Popleteeva, K T Haas, D Stoppa, L Pancheri, L Gasparini, C F Kaminski, L D Cassidy, A R Venkitaraman and A Esposito, "Fast and simple spectral FLIM for biochemical and medical imaging", Opt. Express (2015), 23, 23511-23525    

  1. Hubin E, Deroo S, Schierle G K, Kaminski C F, Serpell L, Subramaniam V, Nuland N v, Broersen K, Raussens V, Sarroukh R, "Two distinct β-sheet structures in Italian mutant amyloid-beta fibrils: a potential link to different clinical phenotypes", Cellular and Molecular Life Sciences (2015), 1-15.   

  1. Steuwe C, Erdelyi M, Szekeres G, Csete M, Baumberg J, Mahajan S, Kaminski CF, "Visualizing electromagnetic fields at the nanoscale by single molecule localization", Nano Letters (2015) 15 (5), 3217-3223.  

  1. Mahou P, Curry N, Pinotsi D, Kaminski-Schierle GS, Kaminski CF, "Stimulated emission depletion microscopy to study amyloid fibril formation", SPIE NanoScience+ Engineering, VIII, 93310U.  

  1. Chmielewski AK, Kyrsting A, Mahou P, Wayland M, Muresan L, Evers JF, Kaminski CF, "Fast imaging of live organisms with sculpted light sheets", Scientific Reports (2015), 5, 9385.  

  1. Davies T, Kodera N, Kaminski-Schierle G S, Rees EJ, Erdelyi M, Kaminski CF, Ando T, Mishima M, "CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation", PLoS Biol. (2015), 13(4): e1002121.  

  1. Chen WY, Avezov E, Schlachter SC, Gielen F, Laine RF, Harding HP, Hollfelder F, Ron D and Kaminski CF, "A Method to Quantify FRET Stoichiometry with Phasor Plot Analysis and Acceptor Lifetime In-growth," Biophys. J. (2015), 108 (5), 2015, pp. 999-1002.  

  1. Laine R F. Albecka A, van de Linde S, Rees EJ, Crump CM, Kaminski CF, "Structural analysis of herpes simplex virus by optical super-resolution imaging", Nature Comms. (2015), 6:5980.  

  1. Avezov E, Konno T, Zyryanova A, Chen WY, Laine R, Crespillo-Casado A, Melo E P, Ushiodo R, Nagata K, Kaminski CF, Harding HP, "Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum", BMC Biology (2015), 13:2.  

  1. Stroehl F, Kaminski CF, "A Joint Richardson-Lucy Deconvolution Algorithm for the Reconstruction of Multifocal Structured Illumination Microscopy Data", Methods Appl. Fluoresc. (2015), 3 (1): 014002.   

  1. Cai W(蔡伟伟), Kaminski CF, "A numerical investigation of high resolution multispectral absorption tomography for flow thermometry", Appl. Phys. B (2015), 1-7. 

  1. Pinotsi D, Kaminski-Schierle GS, Kaminski CF, "Optical superresolution techniques for the study of β-amyloid aggregation in vitro and in vivo: Novel methods and strategies",  in Castrillo, Oliver (eds), 'Systems Biology of Alzheimer ʼs disease' (2015),  Humana Press, Springer, pp 125-141  

  1. Esbjörner E K, Chan F, Rees EJ, Erdelyi M, Luheshi LM, Bertoncini CW, Kaminski CF, Dobson CM, Kaminski-Schierle GS, "Direct Observations of the Formation of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation," Chemistry and Biology, online advance publication (2014). 

  1. Dupont S, Qu Z, Kiwanuka S-S, Hooper L E, Knight J C,  Keiding S R, and Kaminski C F, "Ultra-high repetition rate absorption spectroscopy with low noise supercontinuum radiation generated in an all-normal dispersion fibre," Laser Phys. Lett., 11 075601, (2014). 

  1. Cai W, Kaminski CF, "Multiplexed absorption tomography with calibration-free wavelength modulation spectroscopy" Applied Physics Letters, 104, 154106, (2014). 

  1. Sinkó J, Kákonyi R, Rees E, Metcalf D, Knight AE, Kaminski CF, Szabó G, Erdélyi, "TestSTORM: Simulator for optimizing sample and image acquisition in localization based super-resolution microscopy, " Biomed. Opt. Exp., 5 (3), pp. 778-787, (2014). 

  1. Michel CH, Kumar S, Pinotsi D, Tunnacliffe A, St George-Hyslop P, Mandelkow E, Mandelkow E-M, Kaminski CF, Kaminski Schierle GS, "Extracellular Monomeric Tau is Sufficient to Initiate the Spread of Tau Pathology", J. Biol. Chem., 289: 956-967, (2014). 

  1. Cai W, Kaminski CF, "A tomographic technique for the simultaneous imaging of temperature, chemical species, and pressure in reactive flows using absorption spectroscopy with frequency-agile lasers" Appl. Phys. Lett., 034101, (2014).  

  1. Kaminski-Schierle GS, Sauer M, Kaminski CF, "Probing Amyloid Aggregation and Morphology In Situ by Multiparameter Imaging and Super-Resolution Fluorescence Microscopy," in Uversky VN, Lyubchenko YL, (eds)  Bio-nanoimaging: Protein Misfolding & Aggregation, Academic Press, pp. 105-120, (2014). 

  1. Chan FTS, Pinotsi D, Kaminski-Schierle GS, Kaminski CF,  "Structure-Specific Intrinsic Fluorescence of Protein Amyloids Used to Study their Kinetics of Aggregation," in Uversky VN, Lyubchenko YL, (eds)  Bio-nanoimaging: Protein Misfolding & Aggregation, Academic Press, pp. 147-155, (2014). 

  1. Kaminski CF, Rees EJ, Schierle GS, "A quantitative protocol for intensity-based live cell FRET imaging". Methods Mol. Biology, 1076:445-454, (2014).  

  1. Pinotsi D, Büll AK, Galvagnion C, Dobson CM, Kaminski-Schierle GS, Kaminski CF, "Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy," Nano Letters, 14 (1), 339–345, (2013). 

  1. Yan J, Bauer W-A C, Fischlechner M, Hollfelder F, Kaminski CF, Huck WTS, "Monodisperse Water-in-Oil-in-Water (W/O/W) Double Emulsion Droplets as Uniform Compartments for High-Throughput Analysis via Flow Cytometry," Micromachines, 4, 402-413, (2013). 

  1. Qu Z, Engstrom J, Wong D, Meez I, Kaminski CF, "High sensitivity liquid phase measurements using broadband cavity enhanced absorption spectroscopy (BBCEAS) featuring a low cost webcam based prism spectrometer", Analyst, 138, 6372-6379, (2013).  

  1. Jeyasekharan AD, Liu Y, Hattori H, Pisupati V, Jonsdottir AB, Rajendra E, Lee M, Sundaramoorthy E, Schlachter S, Kaminski CF, Rosenfeld Y, Sato K, Savill J, Ayoub N, Venkitaraman AR, "A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization", Nature Struct. & Mol. Biol., 20,1191–1198 (2013). 

  1. Erdelyi M, Rees EJ, Metcalf D, Kaminski-Schierle GS, Dudas L, Sinko J, Knight AE, Kaminski CF, "Correcting chromatic offset in multicolor super-resolution localization microscopy", Opt. Express 21 (9), 10978–10988 (2013).  

  1. Rees EJ, Erdelyi M, Kaminski-Schierle GS, Knight AE and Kaminski CF, "Elements of image processing in localisation microscopy", J. Optics 15, 094012 (2013).  

  1. Gooding C, Edge C, Lorenz M, Coelho MB, Winters M, Kaminski CF, Cherny D, Eperon IC, Smith CWJ, "MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3", Nucleic Acids Research, 41 (9): 4765-4782, (2013). 

  1. Pinotsi D, Buell AK, Dobson CM, Kaminski Schierle GS and Kaminski CF, "A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence", ChemBioChem, 14 (7), 846-850, (2013).  

  1. Avezov E, Cross BCS, Kaminski Schierle GS, Winters M, Harding HP, Melo EP, Kaminski CF, Ron D, "Lifetime imaging of a fluorescent protein sensor tracks ER thiol redox revealing its surprising stability", J. Cell. Biol., 201 (2), 337-349, (2013).  

  1. Chan FTS, Kaminski Schierle GS, Kumita JR, Bertoncini CW, Dobson CM and Kaminski CF, "Protein amyloids develop an intrinsic fluorescence signature during aggregation", Analyst,  138 (7), 2156-216 (2013).  

  1. Christie RSM, Burns IS, Kaminski CF, "Temperature Response of an Acoustically-Forced Turbulent Lean Premixed Flame: A Quantitative Experimental Determination", Comb. Sci. Tech., 185:1, 180-199, (2013). 

  1. Rees EJ, Erdelyi MJ, Pinotsi D, Knight A, Metcalf D and Kaminski CF, "Blind Assessment of Localisation Microscope Image Resolution", Optical Nanoscopy 1(12):1-10, (2012). 

  1. Ahn M, De Genst E, Kaminski Schierle GS, Erdelyi M, Kaminski CF, Dobson CM, Kumita JR, "Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme", PLoS ONE 7(11): e50192, (2012).  

  1. Kiwanuka SS, Laurila TK, Frank JH, Esposito A, Blomberg von der Geest K, Pancheri L, Stoppa D, Kaminski CF, "Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes", Anal. Chem., 84 (13), pp 5489–5493 (2012). 

  1. Liu C, Rees EJ, Laurila T, Jian S, Kaminski CF, "Periodic interactions between solitons and dispersive waves during the generation of non-coherent supercontinuum radiation", Opt. Exp., 20 (6), 6316-6324 (2012). 

  1. Murakami T, Yang S, Xie L, Kawano T, Fu D, Mukai A, Bohm C, Chen F, Robertson J, Suzuki H, Tartaglia GG, Vendruscolo M, Kaminski Schierle GS, Chan FTS, Moloney A, Crowther D, Kaminski CF, Zhen M, St. George-Hyslop P, "ALS mutations in FUS causes neuronal dysfunction and death in C. elegans by a dominant gain-of-function mechanism", Hum. Mol. Genet., 21(1), pp 1-9, (2012). 

  1. Chakrabortee S, Tripathi R, Watson M, Kaminski Schierle GS, Kurniawan DP, Kaminski CF, Wise MJ, Tunnacliffe A, "Intrinsically disordered proteins as molecular shields", Mol. BioSyst, 8(1), pp 210-219, (2012). 

  1. Steuwe C, Kaminski CF, Baumberg JJ, Mahajan S, "Surface Enhanced Coherent Anti-Stokes Raman Scattering on Nanostructured Gold Surfaces", Nano Letters , 11 (12), 5339-5343, (2011). 

  1. Burns IS, Kaminski CF, "Diode laser induced fluorescence for gas-phase diagnostics", Z. Phys. Chem., 225 (11-12), 1343-1368, (2011).  

  1. Kaminski Schierle GS, van de Linde S, Erdelyi M, Esbjörner EK, Klein T, Rees E, Bertoncini CW, Dobson CM, Sauer M, and Kaminski CF, "In Situ Measurements of the Formation and Morphology of Intracellular ß-Amyloid Fibrils by Super-Resolution Fluorescence Imaging", J. Am. Chem. Soc., 133 (33), pp 12902–12905, (2011).  

  1. Laurila TK, Sorvajarvi T, Saarela J, Toivonen J, Wheeler DW, Ciaffoni L, Ritchie GAD, and Kaminski CF, "Optical Detection of the Anesthetic Agent Propofol in the Gas Phase", Anal. Chem., 83 (10), pp 3963–3967, (2011). 

  1. Sedransk KL, Kaminski CF, Hutchings LR, and Moggridge GD, "The metathetic degradation of polyisoprene and polybutadiene in block copolymers using Grubbs second generation catalyst", Polymer Deg. Stab., 96 (6), pp 1074-1080, (2011).  

  1. Kaminski CF, Sackmann E, Schulten K, "Theodor Förster: A Giant of Modern Photochemistry (Editorial)", ChemPhysChem, 12(3), 423-424, (2011).  

  1. Esposito A, Bader AN, Schlachter SC, van den Heuvel DJ, Kaminski Schierle GS, Venkitaraman AR, Kaminski CF, Gerritsen HC, "Design and application of a confocal microscope for spectrally resolved anisotropy imaging", Opt. Exp., 19(3), 2546-2555, (2011).  

  1. T. Laurila, I.S. Burns, J. Hult, J.H. Miller and C.F. Kaminski, "A calibration method for broad bandwidth cavity enhanced absorption spectroscopy performed with supercontinuum radiation", Appl. Phys. B, Vol. 102(2), 271-278, (2011).  

  1. Kaminski Schierle GS, Bertoncini CW, Chan FTS, van der Goot AT, Schwedler S, Skepper J, Schlachter S, van Ham T, Esposito A, Kumita JR, Nollen EAA, Dobson CM, Kaminski CF, "A FRET sensor for non-invasive imaging of amyloid formation in vivo", ChemPhysChem, 12(3), 673–680, (2011).  

  1. Chan FTS, Kaminski CF, and Kaminski Schierle, "HomoFRET fluorescence anisotropy imaging as a tool to study molecular self-assembly in live cells", ChemPhysChem, 12, Issue 3, pages 500–509, February 25, 2011 (2011).  

  1. Mauritz JMA, Seear R, Esposito A, Kaminski CF, Skepper J, Warley A, Lew VL, Tiffert T, "X-ray Microanalysis Investigation of the Stage-Related Changes in Na, K and Hemoglobin Concentration in Plasmodium Falciparum-Infected Red Blood Cells", Biophys. J., 100 (6), pp 1438-1445, (2011).  

  1. Burns IS, Mercier X, Wartel M, Chrystie RS, Hult JF, Kaminski CF, "A method for performing high accuracy temperature measurements in low-pressure sooting flames using two-line atomic fluorescence", Proc. Comb. Inst. 33(1), 799-806, (2011).  

  1. Chakraborty N, Hartung G, Katragadda M, Kaminski CF, "Comparison of 2D and 3D density-weighted displacement speed statistics and implications for laser based measurements of flame displacement speed using Direct Numerical Simulation data", Comb. Flame, 158 (7), pp 1372-1390, (2011).  

  1. Swietach, Tiffert, Mauritz, Seear, Esposito, Kaminski, Lew, Vaughan-Jones, "Hydrogen ion dynamics in human red blood cells", J. Physiology 588 (24), 4995–5014, (2010).  

  1. Liu C, Rees EJ, Laurila T, Jian S, Kaminski CF, "Predicting supercontinuum pulse collisions with simulations exhibiting temporal aliasing", Opt. Lett., 35 (24), 4145-4147 (2010).  

  1. Liu C, Rees EJ, Laurila T, Jian S, Kaminski CF, "An adaptive filter for studying the life cycle of optical rogue waves", Opt. Express, 18 (25), 26113-26122, (2010).  

  1. Esbjörner EK, Bertoncini C, Schlachter S, Dobson CM, Kaminski CF, Schierle Kaminski GS, "Multiparametric fluorescence microscopy imaging of amyloid beta allows for direct observations of protein misfolding in vitro and in cells", FEBS Journal 277, p86, (2010).  

  1. Chakrabortee S, Meersman F, Kaminski Schierle GS, Bertoncini CW, McGee B, Kaminski CF, Tunnacliffe A, "Catalytic and chaperone-like functions in an intrinsically disordered protein associated with desiccation tolerance", PNAS, 107 (37), 16084-16089, (2010).  

  1. Kiwanuka SS, Laurila T, Kaminski CF, "Sensitive Method for the Kinetic Measurement of Trace Species in Liquids Using Cavity Enhanced Absorption Spectroscopy with Broad Bandwidth Supercontinuum Radiation", Anal. Chem., 82 (17), pp 7498–7501 (2010).  

  1. Mauritz JM, Esposito A, Tiffert T, Skepper JN, Warley A, Yoon Y-Z, Cicuta P, Lew VL, Guck JR, Kaminski CF, "Biophotonic techniques for the study of malaria-infected red blood cells", MBEC, 48 (10), pp 1055, (2010).  

  1. Mauritz J, Tiffert T, Seear R, Lautenschläger F, Esposito A, Lew V, Guck J, Kaminski F, "Detection of Plasmodium falciparum infected red blod cells by optical stretching", J. Biomed. Opt., Vol. 15, 030517 (2010).  

  1. Esposito A, Choimet JB, Skepper J, Mauritz JMA, Lew VL, Kaminski CF, Tiffert T, "Quantitative imaging of human red blood cells infected with Plasmodium falciparum", Biophys. J., 99 (3), 953-960, (2010).  

  1. Cheung W, Gill M, Esposito A, Kaminski CF, Courousse N, Chwetzoff S, Trugnan G, Burrone O, Lever A, Desselberger U, "Rotaviruses associate with cellular lipid droplet components to replicate in viroplasms, and compounds disrupting or blocking lipid droplets inhibit viroplasm formation and viral replication", J. Virology, 84 (13), 6782-6798, (2010). 

  1. van Ham TJ, Esposito A, Kumita JR, Hsu ST, Kaminski Schierle GS, Kaminski CF, Dobson CM, Nollen EA, Bertoncini CW, "Towards multiparametric fluorescent imaging of amyloid formation: Studies of a YFP model of alpha-synuclein aggregation", J. Mol. Biol. 395, 627–642, (2010).  

  1. Watt R, Laurila T, Kaminski CF, Hult JF, "Cavity enhanced spectroscopy of high temperature H2O in the near infrared using a supercontinuum light source", Appl. Spect. 63 (12), 1389-1395, (2009).  

  1. van der Sneppen L, Hancock G, Kaminski CF, Laurila T, Mackenzie SR, Neil SRT, Peverall , Ritchie GAD, Schnippering M, Unwin PR, "Following interfacial kinetics in real time using broad-band evanescent-wave cavity-enhanced absorption spectroscopy: A comparison of light-emitting diodes and supercontinuum sources", Analyst 135 (1): 133-139, (2010).  

  1. Elder AD, Kaminski CF,and Frank, JH, "Phi-Squared FLIM: a technique for alias-free frequency domain fluorescence lifetime imaging", Opt. Exp. 17, 23181–23203 (2009).  

  1. Schlachter S, Schwedler S, Esposito A, Kaminski Schierle G, Moggridge GD, Kaminski CF, "A method to unmix multiple fluorophores in microscopy images with minimal a priori information", Opt. Exp. 17(25). 22747, (2009).  

  1. Abdolvand A, Nazarkin A, Chugreev AV, Kaminski CF, Russell PStJ, "Solitary Pulse Generation by Backward Raman Scattering in H2-Filled Photonic Crystal Fibers", Phys. Rev. Lett. 103, 183902, (2009).  

  1. Hartung G, Hult J, Balachandran R, Macklay MR, Kaminski CF, "Flame front tracking in turbulent lean premixed flames using stereo PIV and time sequenced planar LIF of OH", Appl. Phys. B 96, 843, (2009).  

  1. Chrystie RSM, Burns IS, Hult JF, Kaminski CF, "High-repetition-rate combustion thermometry with two-line atomic fluorescence excited by diode lasers," Opt. Lett. 34, 2492-2494, (2009).  

  1. Müller CR, Hartung G, Hult J, Dennis JS, Kaminski CF, "Laser Diagnostic Investigation of the Bubble Eruption Patterns in the Freeboard of Fluidized Beds: Simultaneous Acetone PLIF and Stereoscopic PIV Measurements", A.I.Chem.E J., 55(6), 1369-1382, (2009).  

  1. Mauritz J, Morrisby R, Hutton R, Legge C, Kaminski CF, "Imaging Pharmaceutical Tablets with Optical Coherence Tomography", J. Pharm. Sci. 98(7), (2009).  

  1. Mauritz J, Esposito A, Ginsburg H, Kaminski CF, Tiffert T and Lew VL, "The Homeostasis of Plasmodium falciparum Infected Red Blood Cells", PLoS Comput Biol 5(4): e1000339, (2009).  

  1. Schlachter S, Elder AD, Esposito A, Kaminski GS, Frank GH, van Geest LK, and Kaminski CF, "mhFLIM: Resolution of heterogeneous fluorescence decays in widefield lifetime microscopy", Opt Express, Volume 17, pp. 1557-1570, (2009).  

  1. Kaminski CF, "Quantitative Fluorescence Microscopy" (Introduction), J. Roy. Soc. Int., Volume 6, S1-S2, (2009).  

  1. Elder AD, Domin A, Kaminski Schierle GS, Lindon C, Pines J, Esposito A, and Kaminski CF, "A quantitative protocol for dynamic measurements of protein interactions by FRET-sensitized fluorescence emission". J. Roy. Soc. Int., Volume 6, S59-S81, (2009).  

  1. Esposito A, Schlachter S, Kaminski Schierle GS, Elder AD, Diaspro A, Wouters FS, Kaminski CF, Iliev AI, "Quantitative fluorescence microscopy techniques" Methods Mol Biol. 586:117-42, (2009).  

  1. Ayoola B, Hartung G, Armitage CA, Hult J, Cant RS, Kaminski CF, "Temperature response of turbulent premixed flames to inlet velocity oscillations" Exp.in Fluids, 46, 27-41, (2009).  

  1. Esposito A, Tiffert T, Mauritz J, Schlachter S, Bannister LH, Kaminski CF, Lew VL, "FRET Imaging of Haemoglobin Concentration in Plasmodium Falciparum Infected Erythrocytes". PLoS ONE, 3(11): e3780, (2008).  

  1. Euser TG, Whyte G, Scharrer M, Chen JSY, Abdolvand A, Nold J, Kaminski CF, Russell PStJ "Dynamic control of higher-order modes in hollow-core photonic crystal fibers" Opt. Exp, Vol. 16, Issue 22, pp. 17972-17981, (2008).  

  1. Burns IS, Lamoureux M, Kaminski CF, Hult J, Desgroux P, "Diode laser atomic fluorescence temperature measurements in low-pressure flames", Appl. Phys B 93:907-914 (2008).  

  1. Dai X, Zhou F, Khan N, Huck, WTS and Kaminski CF "Direct Visualization of Reversible Switching of Micropatterned Polyelectrolyte Brushes on Gold Surfaces Using Laser Scanning Confocal Microscopy" Langmuir, 24 (22), pp 13182–131858, (2008). 

  1. Chrystie RSM, Burns IS, Hult J and Kaminski CF  "On the improvement of two-dimensional curvature computation and its application to turbulent premixed flame correlations" Meas. Sci. Tech.,. 19 125503, (2008).  

  1. M. Schnippering, P.R. Unwin, J. Hult, T. Laurila, C.F. Kaminski, J.M. Langridge, R.L. Jones, M. Mazurenka, S.R. Mackenzie, "Evanescent Wave Broadband Cavity Enhanced Absorption Spectroscopy using Super-continuum Radiation: A New Probe of Electrochemical Processes", Electrochem. Comm., 10:1827-1830, (2008). 

  1. Kaminski CF, Watt RS, Elder AD, Frank JH, Hult J, "Supercontinuum radiation for applications in chemical sensing and microscopy" Appl. Phys. B 92:367-378 (2008).  

  1. Schlachter S, Elder A, Frank JH, Grudinin A, Kaminski CF, "Spectrally resolved confocal fluorescence microscopy with a supercontinuum laser" Micr. Analysis, (4) 2008 

  1. Hartung G, Müller CR, Hult J, Dennis JS, Kaminski CF, "Laser Diagnostic Investigation of the Bubble Eruption Patterns in the Freeboard of Fluidized Beds. 1. Optimization of Acetone Planar Laser Induced Fluorescence Measurements" Ind. Eng. Chem. Res. 47:5686-5697 (2008).  

  1. Langridge J, Laurila T, Watt RS, Jones RL, Kaminski CF, Hult J, "Cavity enhanced absorption spectroscopy of multiple trace gas species using a supercontinuum radiation source" Opt. Exp. 16(14):10178-10188, (2008).  

  1. Hartung, G; Hult, J; Kaminski, CF; Rogerson, JW; Swaminathan, N, "Effect of heat release on turbulence and scalar-turbulence interaction in premixed combustion", Phys. Fluids, 20:035110 (2008).  

  1. Fidalgo, LM; Whyte, G; Bratton, D; Kaminski, CF; Abell, C; Huck, WTS, "From microdroplets to microfluidics: Selective emulsion separation in microfluidic devices", Angewandte Chemie-Int. Ed. 47:2042-2045(2008). 

  1. Dai X, Yue Z, Eccleston M, Swartling J, Slater N, Kaminski CF, "Fluorescence intensity and lifetime imaging of free and micellar-encapsulated doxorubicin in living cells" Nanomedicine, (4) 49-56, (2008).  

  1. Elder, A; Schlachter, S; Kaminski, CF, "Theoretical investigation of the photon efficiency in frequency-domain fluorescence lifetime imaging microscopy", JOSA A, 25:452-462, (2008).  

  1. Watt, RS; Kaminski, CF; Hult, J, "Generation of supercontinuum radiation in conventional single-mode fibre and its application to broadband absorption spectroscopy", Appl. Phys. B, 90:47-53, (2008).  

  1. Burns, IS; Hult, J; Hartung, G; Kaminski, CF, "A thermometry technique based on atomic lineshapes using diode laser LIF in flames", Proc. Comb. Inst. 31:775-782, (2007).  

  1. Hult, J; Gashi, S; Chakraborty, N; Klein, M; Jenkins, KW; Cant, S; Kaminski, CF, "Measurement of flame surface density for turbulent premixed flames using PLIF and DNS", Proc. Comb. Inst., 31:1319-1326, (2007).  

  1. Hult, J; Watt, RS; Kaminski, CF, "High bandwidth absorption spectroscopy with a dispersed supercontinuum source", Opt. Exp., 15:11385-11395, (2007).  

  1. Frank, JH; Elder, AD; Swartling, J; Venkitaraman, AR; Jeyasekharan, AD; Kaminski, CF, "A white light confocal microscope for spectrally resolved multidimensional imaging", J. Microscopy, 227:203-215, (2007).  

  1. Boushaba, R; Kaminski, CF; Slater, NKH, "Dual fluorescence confocal imaging of the accessibility and binding of F(ab')2 to an EBA resin with various immobilised antigen densities", Proc. Biochem., 42:812-819, (2007).  

  1. Matthews, SM; Elder, AD; Yunus, K; Kaminski, CF; Brennan, CM; Fisher, AC, "Quantitative kinetic analysis in a microfluidic device using frequency-domain fluorescence lifetime imaging", Anal. Chem., 79:4101-4109, (2007).  

  1. Hult, J; Watt, RS; Kaminski, CF, "Dispersion measurement in optical fibers using supercontinuum pulses", JLT, 25:820-824, (2007).  

  1. Walti, C; Germishuizen, WA; Tosch, P; Kaminski, CF; Davies, AG, "AC electrokinetic manipulation of DNA", J. Phys. D,  40:114-118, (2007).  

  1. Elder, AD; Frank, JH; Swartling, J; Dai, X; Kaminski, CF, "Calibration of a wide-field frequency-domain fluorescence lifetime microscopy system using light emitting diodes as light sources", J. Microscopy, 224:166-180, (2006).  

  1. Hartung, G; Hult, J; Kaminski, CF, "A flat flame burner for the calibration of laser thermometry techniques", Meas. Sci. Tech., 17:2485-2493(2006).  

  1. Elder, AD; Matthews, SM; Swartling, J; Yunus, K; Frank, JH; Brennan, CM; Fisher, AC; Kaminski, CF, "The application of frequency-domain Fluorescence Lifetime Imaging Microscopy as a quantitative analytical tool for microfluidic devices", Opt. Exp. 14:5456-5467, (2006). 

  1. Bustnes, TE; Kaminski, CF; Mackley, MR, "The capture and release of biomass in a high voidage fibrous microstructure: Mechanisms and shear stress levels", J. Membrane Science., 276:208-220, (2006). 

  1. Walti, C; Tosch, P; Davies, AG; Germishuizen, WA; Kaminski, CF, "Establishment of the ac electrokinetic elongation mechanism of DNA by three-dimensional fluorescent imaging", Appl. Phys. Lett. 88:153901, (2006).  

  1. Dai, XW; Eccleston, ME; Yue, ZL; Slater, NKH; Kaminski, CF, "A spectroscopic study of the self-association and inter-molecular aggregation behaviour of pH-responsive poly(L-lysine iso-phthalamide)", Polymer, 47:2689-2698, (2006). 

  1. Burns, IS; Hult, J; Kaminski, CF, "Use of Te-130(2) for frequency referencing and active stabilisation of a violet extended cavity diode laser", Spectrochim. Acta A, 63:905-909, (2006).  

  1. Ayoola, BO; Balachandran, R; Frank, JH; Mastorakos, E; Kaminski, CF, "Spatially resolved heat release rate measurements in turbulent premixed flames", Comb. Flame, 144:1-16, (2006).  

  1. Hult, J; Burns, IS; Kaminski, CF, "High repetition-rate wavelength tuning of an extended cavity diode laser for gas phase sensing", Appl. Phys. B, 81:757-760, (2005).  

  1. Balachandran, R; Ayoola, BO; Kaminski, CF; Dowling, AP; Mastorakos, E, "Experimental investigation of the nonlinear response of turbulent premixed flames to imposed inlet velocity oscillations", Comb. Flame, 143:37-55, (2005). 

  1. Kaminski, CF, "Fluorescence imaging of reactive processes", Z. Phys. Chem., 219:747-774, (2005).  

  1. Hult, J; Meier, U; Meier, W; Harvey, A; Kaminski, CF, "Experimental analysis of local flame extinction in a turbulent jet diffusion flame by high repetition 2-D laser techniques and multi-scalar measurements", Proc. Comb. Inst., 30:701-709, (2005). 

  1. Gashi, S; Hult, J; Jenkins, KW; Chakraborty, N; Cant, S; Kaminski, CF, "Curvature and wrinkling of premixed flame kernels - comparisons of OHPLIF and DNS data", Proc. Comb. Inst., 30:809-817, (2005).  

  1. Hult, J; Burns, IS; Kaminski, CF, "Two-line atomic fluorescence flame thermometry using diode lasers", Proc. Comb. Inst., 30:1535-1543, (2005).  

  1. McNesby, K; Kaminski, C; Yalin, A, "Laser applications to chemical and environmental analysis: introduction", Appl. Opt., 44:3637-3637, (2005). 

  1. Hult J, Burns IS, Kaminski CF  "Wide bandwidth mode-hop free tuning of extended cavity GaN diode lasers" Appl. Opt. 44:3675-3685, (2005). 

  1. Burns IS, Hult J, Kaminski CF "Diode laser induced fluorescence spectroscopy for combustion thermometry" J. Physics 15:201-206, (2005).  

  1. Burns IS, Hult J, Kaminski CF, "Spectroscopic use of a novel blue diode laser in a wavelength region around 450 nm" Applied Physics B 79:491-495, (2004).  

  1. Bustnes, TE; Kaminski, CF; Mackley, MR, "Direct visualization of flowing biomass capture and release within a fibrous matrix", Biochem. Eng. J., 18:231-234, (2004). 

  1. Hult, J; Burns, IS; Kaminski, CF, "Measurements of the indium hyperfine structure in an atmospheric-pressure flame by use of diode-laser-induced fluorescence", Opt. Lett., 29:827-829, (2004).  

  1. Eccleston, ME; Kaminski, CF; Slater, NKH; Briggs, MSJ, "Optical characteristics of responsive biopolymers; co-polycondensation of tri-functional amino acids and Cy-3 bis-amine with diacylchlorides", Polymer 45:25-32, (2004). 

  1. Abu-Gharbieh, R; Hamarneh, G; Gustavsson, T; Kaminski, C, "Level set curve matching and particle image velocimetry for resolving chemistry and turbulence interactions in propagating flames", J. Math. Imag. Vision, 19:199-218, (2003).  

  1. Metz, T; Walewski, J; Kaminski, CF, "Maximum-likelihood curve-fitting scheme for experiments with pulsed lasers subject to intensity fluctuations", Appl. Opt., 42:1551-1563, (2003).  

  1. Hult, J; Omrane, A; Nygren, J; Kaminski, CF; Axelsson, B; Collin, R; Bengtsson, PE; Alden, M, "Quantitative three-dimensional imaging of soot volume fraction in turbulent non-premixed flames", Exp. Fluids, 33:265-269, (2002).  

  1. Hult, J; Richter, M; Nygren, J; Alden, M; Hultqvist, A; Christensen, M; Johansson, B, "A high speed laser spectroscopic imaging system for cycle resolved imaging and three-dimensional imaging in IC engines", Appl. Opt., 41:5002-5014, (2002).  

  1. Nygren, J; Hult, J; Richter, M; Alden, M; Christensen, M; Hultqvist, A; Johansson, B, "Three-dimensional Laser Induced Fluorescence of Fuel Distributions in an HCCI Engine", Proc. Comb. Inst., 29:679-685, (2002).  

  1. Hultqvist, A; Christensen, M; Johansson, B; Richter, M; Nygren, J; Hult, J; Alden, M, "The HCCI Combustion Process in a Single Cycle - High-Speed Fuel Tracer LIF and Chemiluminescence Imaging", SAE Paper No. 2002-01-0424, (2002).  

  1. Walewski, J; Kaminski, CF; Hanna, SF; Lucht, RP, "Dependence of partially saturated polarization spectroscopy signals on pump intensity and collision rate", Phys. Rev. A, 6406, (2001). 

  1. Nygren, J; Engstrom, J; Walewski, J; Kaminski, CF; Alden, M, "Applications and evaluation of two-line atomic LIF thermometry in sooting combustion environments", Meas. Sci. Tech., 12:1294-1303, (2001).  

  1. Abu-Gharbieh, R; Hamarneh, G; Gustavsson, T; Kaminski, CF, "Flame front tracking by laser induced fluorescence spectroscopy and advanced image analysis", Opt. Exp., 8:278-287, (2001).  

  1. Kaminski, CF; Hult, J; Alden, M; Lindenmaier, S; Dreizler, A; Maas, U; Baum, M, "Spark ignition of turbulent methane/air mixtures revealed by time-resolved planar laser-induced fluorescence and direct numerical simulations", Proc. Comb. Inst., 28:399-405, (2000).  

  1. Malm, H; Sparr, G; Hult, J; Kaminski, CF, "Nonlinear diffusion filtering of images obtained by planar laser-induced fluorescence spectroscopy", JOSA A, 17:2148-2156, (2000).  

  1. Kaminski, CF; Bai, XS; Hult, J; Dreizler, A; Lindenmaier, S; Fuchs, L, "Flame growth and wrinkling in a turbulent flow", App. Phys. B., 71:711-716, (2000).  

  1. Engstrom, J; Nygren, J; Alden, M; Kaminski, CF, "Two-line atomic fluorescence as a temperature probe for highly sooting flames", Opt. Lett., 25:1469-1471, (2000). 

  1. Dreizler, A; Lindenmaier, S; Maas, U; Hult, J; Alden, M; Kaminski, CF, "Characterisation of a spark ignition system by planar laser-induced fluorescence of OH at high repetition rates and comparison with chemical kinetic calculations", Appl. Phys. B., 70:287-294, (2000).  

  1. Kaminski, CF; Dreier, T, "Investigation of two-photon-induced polarization spectroscopy of the a-X (1-0) transition in molecular nitrogen at elevated pressures", Appl. Opt., 39:1042-1048, (2000).  

  1. Kaminski, CF; Hult, J; Richter, M; Nygren, J; Franke, A; Aldén, M; Lindenmaier, S; Dreizler, A; Maas, U; Williams, RB, "Development of high speed spectroscopic imaging techniques for the time resolved study of spark ignition phenomena", SAE, 2000-01-2833, (2000). 

  1. Löfström, C ;Engström, J; Richter, M; Kaminski, CF; Johansson, P; Nyholm, K; Hult, J; Nygren, J; Aldén, M, "Feasibility studies and application of laser/optical diagnostics for characterisation of a practical low-emission gas turbine combustor", ASME, 2000-GT-124, (2000)  

  1. Kaminski, CF; Hult, J; Alden, M, "High repetition rate planar laser induced fluorescence of OH in a turbulent non-premixed flame", Appl. Phys. B, 68:757-760, (1999).  

  1. Engström, J, Kaminski, C.F, Aldén, M, Josefsson, G, Magnusson, I, "Experimental Investigations of Flow and Temperature Fields in an SI Engine and Comparison with Numerical Analysis", SAE, 1999-01-3541, (1999).  

  1. Kaminski, CF; Engström, J, and Aldén, M, "Quasi-instantaneous two-dimensional temperature measurements in a spark ignition engine using 2-line atomic fluorescence" Proc. Comb Inst., 27:85-93 (1998).  

  1. Kaminski, CF; Hughes, IG; Ewart, P, "Degenerate four-wave mixing spectroscopy and spectral simulation of C-2 in an atmospheric pressure oxy-acetylene flame", J. Chem. Phys, 106:5324-5332(1997).  

  1. Kaminski, CF, Engström, J, Aldén, M, "Quasi Instantaneous 2-Dimensional Temperature Measurements in Combustion by Atomic Laser Induced Fluorescence", VDI Berichte 1313, 555–560, (1997).  

  1. Kaminski, CF; Ewart, P, "Multiplex H-2 coherent anti-Stokes Raman scattering thermometry with a modeless laser", Appl. Opt., 36:731-734, (1997). 

  1. Kaminski, CF; Löfstedt, B; Fritzon, R; Alden, M, "Two-photon polarization spectroscopy and (2+3)-photon laser induced fluorescence of N-2", Opt. Comm., 129:38-43, (1996). 

  1. Kaminski, CF; Hughes, IG; Lloyd, GM; Ewart, P, "Thermometry of an oxy-acetylene flame using multiplex degenerate four-wave mixing of C-2", Appl. Phys. B., 62:39-44, (1996).  

  1. Kaminski, C; Ewart, P, "Absolute concentration measurements of C2 in a diamond CVD reactor by laser-induced fluorescence", Appl. Phys. B 61:585-592, (1995). 

 

Teaching and Supervisions

Research supervision: 

The research we do is highly interdisciplinary and we are constantly looking for talented individuals to join the group. Whether you are a biologist keen to use the most advanced imaging tools to understand mechanisms underpinning life, a physicist keen to develop techniques that break the diffraction limit of light, or a computer scientist interested to make imaging systems intelligent to use in drug discovery research - come and talk to us! We are a friendly group providing excellent support for one another and we are all united in our excitement for great science. Visit us and lool at our laboratories and speak to our group members to get a feel for what life in the Laser Analytics group is like.

Professor of Chemical Physics
Director: EPSRC Centre for Doctoral Training in Sensor Technologies and Applications
Laser Analytics Group
Head of Department
Professor Clemens Kaminski

Contact Details

+44 1233 (7)63135
Laser Analytics Group
Email address: 
cfk23@cam.ac.uk

Affiliations

Collaborator profiles: 
Professor Alan Tunnacliffe
Person keywords: 
biochemical engineering
Applied Optics
Microscopy
biosensors
optics
Chemical Sensing
ageing
Chemical Imaging
Sensor

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