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Department of Chemical Engineering and Biotechnology

 
Spore-inspired excipients for the formulation of biopharmaceuticals

Spore-inspired excipients for the formulation of biopharmaceuticals

21 July 2017

Paper published in the International Journal of Pharmaceuticals

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Fluorescent Shell Localisation in Therapeutic Bacteria Spores

Fluorescent Shell Localisation in Therapeutic Bacteria Spores

28 September 2015

On the front cover of the Biophysical Journal for 17 November, CEB researchers present an analytical method to measure the structure of protein layers in bacterial spore coats. This will assist a joint project with MedImmune on the use of live edible bacteria for drug delivery.

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Super-resolution Imaging Techniques

Summary Electron microscopy and electron tomography are powerful tools by which to visualize the physical structure of protein assemblies, but their ability to localize specific proteins is limited. Optical techniques may offer solutions in this regard, but optical diffraction typically limits...

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Magnetic resonance imaging (MRI) of biopharmaceuticals

Summary The ability of magnetic resonance techniques to provide the researcher with non-invasive, quantitative, physicochemical information in the disciplines of chemistry, biology, materials science, chemical engineering and medicine are widely known. In the last 10-15 years a variety of magnetic...

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Continuous Bioprocessing Systems

Summary Bioprocess unit operations are optimised to maximise both product quality and yield. The standard development paradigm, consistent with current Quality by Design and process validation guidance, uses single or multiple factor evaluations with scaled down process equipment. These iterative...

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Exploiting the nature of bacterial spores

Summary Spores of several species of Bacillus have found widespread and safe use as probiotic dietary supplements. More recently, vegetative Bacilli have been engineered using recombinant DNA techniques to form spores that are surface decorated with a wide range of biotechnologically useful...

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Ultra-scale down bioreactors

Summary The majority of therapeutic antibodies are manufactured by mammalian cell culture processes exploiting Chinese hamster ovary (CHO) cells. Annual demands for such antibody products is likely to increase and is driving efforts to improve production capacity. Miniaturised platform cell culture...

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Terahertz investigation of lyophilised antibodies

Summary Terahertz spectroscopy is a potential new tool to help overcoming some of the challenges we face in formulating biopharmaceuticals and bring innovative medicines to the patient. However, terahertz spectroscopy is not yet proven in routine biopharmaceutical analysis; it is still a novel...

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Product Identity Testing

Summary There is a need for ‘Identity Testing’ methods that can determine whether a manufactured solid or liquid pharmaceutical product is genuine and of the intended composition and form, or a defect or counterfeit. In addition, there is general interest in methods for characterising the...

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Nature Communications paper for JJ Phillips

Nature Communications paper for JJ Phillips

20 August 2015

The modus operandi in much of medicine is first to determine the key mechanism of a disease process and then to use a drug to inhibit it. Therefore, on a molecular level, there is often an entity that has an activity that we may wish to turn off. This molecule is termed the ‘drug target’ and a huge amount of effort is made...

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